摘要
背景:新冠肺炎疫情已使世界瘫痪,迫切需要新的战略来识别能够抗击大流行的分子。在过去的几十年里,核磁共振(核磁共振)光谱已经成为抗病毒药物发现领域的一个有趣的结构生物学仪器。 目的:本文综述了如何利用各种基于核磁共振的工具来更好地了解病毒机制,开发抗病毒药物,并建立诊断和治疗途径。 方法:通过PubMed数据库和Web检索本文总结的作品。 结果:该综述集中在一个子部分研究的人类病毒子集。事实上,核磁共振固体溶液态方法允许获得病毒蛋白和病毒基因组的结构信息,或分离或与不同的结合伙伴结合。核磁共振数据可用于建立基于结构的方法,以设计抑制病毒生命周期关键步骤的有效抗病毒药物。此外,基于核mr的代谢组学对病毒感染患者的生物液体进行分析,可以识别疾病的代谢物生物标志物,并跟踪与抗病毒治疗相关的代谢谱的变化,从而为新的诊断和治疗方法铺平了道路。 结论:考虑到基于核磁共振对不同病毒的研究工作,我们认为在不久的将来,将有更多的核磁共振致力于发现新的抗SARS-CoV-2药物。
关键词: 核磁共振,病毒,病毒感染,抗病毒药物,药物发现,基于结构的药物设计,代谢组学。
Current Medicinal Chemistry
Title:The Fight against Human Viruses: How NMR Can Help?
Volume: 28 Issue: 22
关键词: 核磁共振,病毒,病毒感染,抗病毒药物,药物发现,基于结构的药物设计,代谢组学。
摘要:
Background: COVID-19 has brought the world to its knees, and there is an urgent need for new strategies to identify molecules capable of fighting the pandemic. During the last few decades, NMR (Nuclear Magnetic Resonance) spectroscopy has emerged as an intriguing structural biology instrument in the antiviral drug discovery field.
Objective: The review highlights how a variety of NMR-based tools can be employed to better understand viral machineries, develop anti-viral agents and set-up diagnostic and therapeutic routes.
Methods: Works summarized herein were searched through PubMed database and the Web.
Results: The review focuses on a subset of human viruses that have been largely studied through NMR techniques. Indeed, NMR solid- or solution-state methodologies allow to gain structural information on viral proteins and viral genomes either in isolation or bound to diverse binding partners. NMR data can be employed to set up structure-based approaches to design efficient antiviral agents inhibiting crucial steps of viral life cycle. In addition, NMR-based metabolomics analyses of biofluids from virus-infected patients let identify metabolites biomarkers of the disease and follow changes in metabolic profiles associated with antiviral therapy thus paving the way for novel diagnostic and therapeutic approaches.
Conclusion: Considering the NMR-based work conducted on different viruses, we believe that in the near future, much more NMR efforts will be devoted to discovering novel anti SARS-CoV-2 agents.
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Cite this article as:
The Fight against Human Viruses: How NMR Can Help?, Current Medicinal Chemistry 2021; 28 (22) . https://dx.doi.org/10.2174/0929867328666201228123748
DOI https://dx.doi.org/10.2174/0929867328666201228123748 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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