Generic placeholder image

The Natural Products Journal

Editor-in-Chief

ISSN (Print): 2210-3155
ISSN (Online): 2210-3163

Research Article

Lantana undulata Schrank – A New Source of Biological Potential in the Verbenaceae Family

Author(s): D.M.S Ascendino, Barreto T.L, Igídio C.E.D, Castro J.O, Sousa J.S.P, Henriques G.M, Melo M.S, Silva L.D, Oliveira R.A, Oliveira F.F, Melo S.C.O, Malpezzi-Marinho E.L.A and Conceição A.O*

Volume 12, Issue 4, 2022

Published on: 22 December, 2021

Article ID: e231220189412 Pages: 7

DOI: 10.2174/2210315510666201223124135

Price: $65

Abstract

Background: The presence of condensed tannins, flavonones, flavonols, flavones, xantones, catechins and alkaloids in the ethanolic extract of Lantana undulata leaves has been associated with cytotoxicity and virucidal effect on suid herpesvirus.

Objective: To evaluate cellular toxicity, antimicrobial and antioxidant activities, and anti-phlogistic property of the ethanolic extract leaves of Lantana undulata, a plant from the Verbenaceae family.

Methods: Cytotoxicity was evaluated on Madin Darby bovine kidney (MDBK) cells and erythrocytes and through leukocyte DNA damage. Antibacterial and antifungal activities were performed using the agar diffusion technique and broth microdilution. The inhibition percentage and viral inhibition index were established against bovine herpesvirus. The antioxidant effect (EC50) was determined by the DPPH technique and the mouse ear edema model was used to determine the anti-phlogistic activity.

Results: The maximum nontoxic concentration for MDBK cells was 650 μg/ml. The ethanolic extract of L. undulata was considered non-hemolytic from 2 to 16 μg/ml and not genotoxic at the concentration tested (<8 μg/ml). High concentrations (3500 μg/ml) were needed to inhibit bacteria and yeasts, and the action of the extract was bacteriostatic or fungistatic. The IIV was of 0.37 and the IP was of 57.34% against bovine herpesvirus. The antioxidant EC50 was 540.87 μg/ml and the reduction of oedema occurred at 10, 30 and 100 mg/kg in the mouse model used.

Conclusion: Although the ethanolic extract of L. undulataleaves showed to be potentially toxic and to have a reduced spectrum of action on microorganisms, the outstanding antiphlogistic action puts the therapeutic potential of this plant into perspective.

Keywords: Flavonoid, oedema, antibacterial, antifungal, cytotoxicity, tannins.

Graphical Abstract

[1]
Ribeiro, L.H.L. [Analysis of medicinal plant and herbal medicine programs in the Unified Health System (SUS) from the territorial perspective]. Cien. Saude Colet., 2019, 24(5), 1733-1742.
[http://dx.doi.org/10.1590/1413-81232018245.15842017] [PMID: 31166508]
[2]
Brasil. Ministério da Saúde (MS). Política Nacional de Plantas Medicinais e Fitoterápicos, 2006,
[3]
Brasil. Ministério da Saúde (MS). Programa Nacional de Plantas Medicinais e Fitoterápicos, 2009,
[4]
Brasil. Ministério da Saúde. Secretaria de Atenção à Saúde, 2012,
[5]
Day, M.D.; Wiley, C.J.; Playford, J.; Zalucki, M.P. Lantana: Current Management Status and Future Prospects; Australian Centre for International Agricultural Research. Australian Canberra, 2003.
[6]
Ghisalberti, E.L. Lantana camara L. (Verbenaceae). Fitoterapia, 2000, 71(5), 467-486.
[http://dx.doi.org/10.1016/S0367-326X(00)00202-1] [PMID: 11449493]
[7]
Salimena, F.R.G.; Múlgura, M.E. Notas taxonômicas em Verbenaceae do Brasil. Rodriguésia, 2015, 66, 191-197.
[http://dx.doi.org/10.1590/2175-7860201566110]
[8]
Sousa, E.O.; Costa, J.G.M. Genus Lantana: chemical aspects and biological activities. Rev. Bras. Farmacogn., 2012, 22, 1115-1180.
[http://dx.doi.org/10.1590/S0102-695X2012005000058]
[9]
Bezerra, J.E.A.; Costa, A.R.; Rodrigues, F.C.; Duarte, A.E.; Rocha, M.I.; Barros, L.M. Potencial medicinal de Lantana camara l. (Verbenaceae): Uma revisão. Caderno de Cultura e Ciência, 2016, 15, 82-92.
[http://dx.doi.org/10.14295/cad.cult.cienc.v15i1.1079]
[10]
Love, A.; Naik, D.; Basak, S.K.; Babu, S.; Pathak, N.; Babu, C.R. Variability in foliar essential oils among different morphotypes of Lantana species complexes, and its taxonomic and ecological significance. Chem. Biodivers., 2009, 6(12), 2263-2274.
[http://dx.doi.org/10.1002/cbdv.200800284] [PMID: 20020458]
[11]
Lonare, M.K.; Sharma, M.; Hajare, S.W.; Borekar, V.I. Lantana camara: Overview on toxic to potent medicinal properties. Int. J. Pharm. Sci. Res., 2012, 3, 3031-3035.
[12]
Silva, T.R.S.; Salimena, F.R. Lantana in Lista de Espécies da Flora do Brasil Jardim Botânico do Rio de Janeiro, http://www.floradobrasil.jbrj.gov.br/reflora/listaBrasil/FichaPublicaTaxonUC/FichaPublicaTaxonUC.do?id=FB39674
[14]
Silva, L.D.; de Oliveira, F.F.; de Oliveira, R.A.; Fernandes, M.J.B.; da Conceição, A.O. Phytochemical, cytotoxicity, and antiherpesviral comparison between three Lantana species. Asian J. Sci. Tech., 2018, 9, 8722-8726.
[16]
Barros, A.V. Avaliação in vitro do potencial antiviral de extratos da planta Guettarda angelica Mart., 2011,
[17]
Fischer, D.; Li, Y.; Ahlemeyer, B.; Krieglstein, J.; Kissel, T. In vitro cytotoxicity testing of polycations: Influence of polymer structure on cell viability and hemolysis. Biomaterials, 2003, 24(7), 1121-1131.
[http://dx.doi.org/10.1016/S0142-9612(02)00445-3] [PMID: 12527253]
[18]
Carvalho-Silva, R.; Pereira, A.C.F.; Dos Santos Alves, R.P.; Guecheva, T.N.; Henriques, J.A.P.; Brendel, M.; Pungartnik, C.; Rios-Santos, F. DNA protection against oxidative damage using the hydroalcoholic extract of Garcinia mangostana and alpha-mangostin. Evid. Based Complement. Alternat. Med., 2016, 20163430405
[http://dx.doi.org/10.1155/2016/3430405] [PMID: 27042187]
[19]
Tice, R.R.; Agurell, E.; Anderson, D.; Burlinson, B.; Hartmann, A.; Kobayashi, H.; Miyamae, Y.; Rojas, E.; Ryu, J.C.; Sasaki, Y.F. Single cell gel/comet assay: Guidelines for in vitro and in vivo genetic toxicology testing. Environ. Mol. Mutagen., 2000, 35(3), 206-221.
[http://dx.doi.org/10.1002/(SICI)1098-2280(2000)35:3<206::AID-EM8>3.0.CO;2-J] [PMID: 10737956]
[20]
CLSI - Clinical and Laboratory Standards Institute. Method for antifungal disk diffusion susceptibility testing of yeasts: approved guideline M44-A2; Wayne, PA, USA: CLSI, 2010.
[21]
Pedroso, R.S.; Menezes, R.P.; Ferreira, J.C.; Penatti, M.P.A.; Sá, W.M.; Malvino, L.D.S. Antifungal susceptibility of isolates of Candida spp. by disk diffusion and broth microdilution. Biosci. J., 2014, 30, 304-311.
[22]
CLSI - Clinical and Laboratory Standard Institute. Clinical and Laboratory Standard Institute Performance Standards for Antimicrobial Susceptibility Testing; Twenty-Second Informational Supplement, 2012.
[23]
CLSI - Method for antifungal broth dilution susceptibility testing of yeasts: approved guideline M27-A2 Second edition Clinical and Laboratory Standard Institute, 2002,
[24]
Koseki, I; Simoni, IC; Nakamura, IT; Noronha, AB; Costa, SS Antiviral activity of plant extracts against aphthovirus, pseudorabies virus and pestivirus in cell cultures. Microbios lett., 1990, 44, 19-30.
[25]
Nishimura, T.; Toku, H.; Fukuyasu, H. Antiviral compounds. XII. Antiviral activity of amidinohydrazones of alkoxyphenyl-substituted carbonyl compounds against influenza virus in eggs and in mice. Kitasato Arch. Exp. Med., 1977, 50(1-2), 39-46.
[PMID: 616473]
[26]
Mensor, L.L.; Menezes, F.S.; Leitão, G.G.; Reis, A.S.; dos Santos, T.C.; Coube, C.S.; Leitão, S.G. Screening of Brazilian plant extracts for antioxidant activity by the use of DPPH free radical method. Phytother. Res., 2001, 15(2), 127-130.
[http://dx.doi.org/10.1002/ptr.687] [PMID: 11268111]
[27]
Van Arman, C.G. Anti-inflammatory drugs. Clin. Pharmacol. Ther., 1974, 16(5 Part 2), 900-904.
[http://dx.doi.org/10.1002/cpt1974165part2900] [PMID: 4417436]
[28]
Dobričić, V.; Marković, B.; Milenković, N.; Savić, V.; Jaćević, V.; Rančić, N.; Vladimirov, S.; Cudina, O. Design, synthesis, and local anti-inflammatory activity of 17β-carboxamide derivatives of glucocorticoids. Arch. Pharm. (Weinheim), 2014, 347(11), 786-797.
[http://dx.doi.org/10.1002/ardp.201400165] [PMID: 25159891]
[29]
Tamura, EK; Jimenez, RS; Waismam, K; Gobbo-Neto, L; Lopes, NP; Malpezzi-Marinho, ELA. Inhibitory effects of Solidago chilensis Meyen hydroalcoholic extract on acute inflammation. J. Ethnopharmacol., 2009, 122, 478-485.
[30]
Andersen, M.L.; Tufik, S. Animal models as tools in ethical biomedical research; 1st ed.; São Paulo: AFIP, São Paulo, 2011.
[31]
Kalita, S.; Kumar, G.; Karthik, L.; Venkata, K.; Rao, B. In vitro antioxidant and DNA damage inhibition activity of aqueous extract of Lantana camara L. (Verbenaceae) leaves. Asian Pac. J. Trop. Biomed., 2012, 2, S1675-S1679.
[http://dx.doi.org/10.1016/S2221-1691(12)60476-6]
[32]
da Conceição, A.O.; de Oliveira, F.F.; de Oliveira, R.A.; de J da S Junior, A.; Takser, L.; Reyes-Moreno, C.; Lafond, J. Lantana macrophylla Schauer (Verbenaceae) ethanolic extract induces activation of ERK1/2 and p38 MAPKs pathway and Ca2+ imbalance in human trophoblasts derived cell lines. Food Chem. Toxicol., 2012, 50(3-4), 1001-1012.
[http://dx.doi.org/10.1016/j.fct.2011.12.021] [PMID: 22222932]
[33]
Hagerman, A.E. Tannin—Protein Interactions in Phenolic Compounds in Food and Their Effects on Health I; American Chemical Society, 1992, pp. 236-247.
[34]
Kasote, D.M.; Katyare, S.S.; Hegde, M.V.; Bae, H. Significance of antioxidant potential of plants and its relevance to therapeutic applications. Int. J. Biol. Sci., 2015, 11(8), 982-991.
[http://dx.doi.org/10.7150/ijbs.12096] [PMID: 26157352]
[35]
Huyut, Z.; Beydemir, Ş.; Gülçin, İ. Antioxidant and antiradical properties of selected flavonoids and phenolic compounds. Biochem. Res. Int., 2017. 2017, 7616791.
[http://dx.doi.org/10.1155/2017/7616791] [PMID: 29158919]
[36]
Mahdi-Pour, B.; Jothy, S.L.; Latha, L.Y.; Chen, Y.; Sasidharan, S. Antioxidant activity of methanol extracts of different parts of Lantana camara. Asian Pac. J. Trop. Biomed., 2012, 2(12), 960-965.
[http://dx.doi.org/10.1016/S2221-1691(13)60007-6] [PMID: 23593576]
[37]
Pardo, A.K.; Arenas, J.J.; Gómez, M.; Lora, F.M.; Gómez, J.E. Determinación de la actividad antifúngica de extractos de Lantana camara frente a Candida spp. Infect., 2011, 15, 235-242.
[http://dx.doi.org/10.1016/S0123-9392(11)70737-8]
[38]
Günther, C.; Barra, C.; Cesio, M.V.; Dellacassa, E.; Ferreira, F.F.; Garcia, C. Antioxidant properties of Solidago chilensis L. flavonoids. Acta Hortic., 1999, (501), 159-163.
[http://dx.doi.org/10.17660/ActaHortic.1999.501.23]

Rights & Permissions Print Cite
© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version305msRequest Duration28MBMemory UsageGET article/{article_id}/{param?}Route
  • warninglog[18:05:26] LOG.warning: Optional parameter $article_id declared before required parameter $request i...
  • warninglog[18:05:26] LOG.warning: Function strftime() is deprecated in /home/alphaeurekaselec/public_html/stor...
  • warninglog[18:05:26] LOG.warning: trim(): Passing null to parameter #1 ($string) of type string is deprecated ...
  • warninglog[18:05:26] LOG.warning: strip_tags(): Passing null to parameter #1 ($string) of type string is depre...
  • warninglog[18:05:26] LOG.warning: strip_tags(): Passing null to parameter #1 ($string) of type string is depre...
  • warninglog[18:05:26] LOG.warning: Function strftime() is deprecated in /home/alphaeurekaselec/public_html/stor...
  • Booting (102ms)time
  • Application (203ms)time
  • 1 x Application (66.6%)
    203ms
    1 x Booting (33.4%)
    102ms
    14 templates were rendered
    • articlearticle.blade.php#?blade
    • includes.article_top_bannerarticle_top_banner.blade.php#?blade
    • includes.article_referencearticle_reference.blade.php#?blade
    • export_citation_formexport_citation_form.blade.php#?blade
    • includes.article_bottom_bannerarticle_bottom_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • includes.journal_rightmenujournal_rightmenu.blade.php#?blade
    • includes.journal_right_bannerjournal_right_banner.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET article/{article_id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ArticleController@GetArticleDetails
    namespace
    App\Http\Controllers
    where
    as
    article
    file
    app/Http/Controllers/ArticleController.php:1974-2510
    37 statements were executed, 4 of which were duplicates, 33 unique. Show only duplicated119ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('314566706','',1,1739988326,1739988326) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1739988326
      1.01msalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('314566706','/article/112641',1,1739988326,1739988326)
      200μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 314566706 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 314566706) limit 1
      11.57msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 314566706
      • 1: 314566706
      • 2: 314566706
      • 3: 314566706
      • 4: 314566706
      • 5: 314566706
      • 6: 314566706
      • 7: 314566706
      • 8: 314566706
      • 9: 314566706
      • 10: 314566706
      • 11: 314566706
      • 12: 314566706
      • 13: 314566706
      • 14: 314566706
      • 15: 314566706
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year, a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator, a.last_page, i.publication_date, a.file_name, a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name, a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for, (CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle, v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title FROM article a LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id LEFT JOIN journal_section js ON a.js_id = js.js_id LEFT JOIN article_type at ON a.art_type = at.art_type_id LEFT JOIN issue i ON a.issue_id = i.issue_id LEFT JOIN month m ON m.id = i.month_id LEFT JOIN volume v ON v.volume_id = a.volume_id INNER JOIN year y ON y.id = v.year_id INNER JOIN journal j ON j.journal_id = a.journal_id INNER JOIN publisher p ON p.publisher_id = j.publisher_id WHERE a.article_id=112641
      740μsalphaeurekaselec_live_10_06_2022Article.php#408
      Backtrace
      • 11. app/Models/Article.php:408
      • 12. app/Http/Controllers/ArticleController.php:2515
      • 13. app/Http/Controllers/ArticleController.php:2035
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `journal` where `journal_id` = 118 limit 1
      810μsalphaeurekaselec_live_10_06_2022Journal.php#64
      Bindings
      • 0: 118
      Backtrace
      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/ArticleController.php:2516
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=118) and sj.journal_id!=118 group by `j`.`nid`) as `aggregate_table`
      740μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 16. app/Models/Subject.php:200
      • 17. app/Http/Controllers/ArticleController.php:2517
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=118) and sj.journal_id!=118 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
      660μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 14. app/Models/Subject.php:200
      • 15. app/Http/Controllers/ArticleController.php:2517
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=118) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
      2.07msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 16. app/Models/Subject.php:220
      • 17. app/Http/Controllers/ArticleController.php:2518
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=118) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
      1.8msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 14. app/Models/Subject.php:220
      • 15. app/Http/Controllers/ArticleController.php:2518
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `keywords` where `article_id` = '112641'
      290μsalphaeurekaselec_live_10_06_2022Keywords.php#43
      Bindings
      • 0: 112641
      Backtrace
      • 13. app/Models/Keywords.php:43
      • 14. app/Http/Controllers/ArticleController.php:2519
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `article_citation` where `article_id` = '112641'
      2.45msalphaeurekaselec_live_10_06_2022Article.php#1570
      Bindings
      • 0: 112641
      Backtrace
      • 13. app/Models/Article.php:1570
      • 14. app/Http/Controllers/ArticleController.php:2520
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '112641' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      3.7msalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 112641
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ArticleController.php:2533
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      260μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2535
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      490μsalphaeurekaselec_live_10_06_2022Article.php#1960
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1960
      • 14. app/Http/Controllers/ArticleController.php:2062
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 118 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      26.62msalphaeurekaselec_live_10_06_2022Issue.php#298
      Backtrace
      • 11. app/Models/Issue.php:298
      • 12. app/Http/Controllers/ArticleController.php:2068
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 118 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      5.24msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2070
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 118 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      3.96msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2071
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select pdf, html, epub, prc from `article_metrics` where `article_id` = 112641 limit 1
      240μsalphaeurekaselec_live_10_06_2022Article.php#744
      Bindings
      • 0: 112641
      Backtrace
      • 14. app/Models/Article.php:744
      • 15. app/Http/Controllers/ArticleController.php:2091
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from content_by_diseases where content_id = 112641 and content_type = 'article' order by status desc limit 1
      320μsalphaeurekaselec_live_10_06_2022Article.php#751
      Backtrace
      • 11. app/Models/Article.php:751
      • 12. app/Http/Controllers/ArticleController.php:2094
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid article_nid,a.title article_title,j.title journal_title from content_by_diseases cd inner join article a on a.article_id=cd.content_id inner join journal j on j.journal_id=a.journal_id where cd.pid = 281 and cd.sub_disease_id = 513 and content_id!=112641 and cd.content_type = 'article' order by rand() limit 20
      25.26msalphaeurekaselec_live_10_06_2022Article.php#769
      Backtrace
      • 11. app/Models/Article.php:769
      • 12. app/Http/Controllers/ArticleController.php:2098
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 189412 limit 1
      320μsalphaeurekaselec_live_10_06_2022Meta.php#30
      Bindings
      • 0: 189412
      Backtrace
      • 14. app/Models/Meta.php:30
      • 15. app/Http/Controllers/ArticleController.php:2101
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      310μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2108
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'NPJ' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
      350μsalphaeurekaselec_live_10_06_2022Article.php#2025
      Bindings
      • 0: NPJ
      Backtrace
      • 13. app/Models/Article.php:2025
      • 14. app/Http/Controllers/ArticleController.php:2112
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '112641' and content_type = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      450μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2186
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '11614' and content_type = 'i' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      420μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2207
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '3180' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      410μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2231
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314566706 and j.to_ip >=314566706 )) and ((j.from_date <= 1739988326 and j.to_date >= 1739988326 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3180) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314566706 and j.to_ip >=314566706 )) and ((j.from_date <= 1739988326 and j.to_date >= 1739988326 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3180) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314566706 and j.to_ip >=314566706 )) and ((j.from_date <= 1739988326 and j.to_date >= 1739988326 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3180)
      19.77msalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2272
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314566706 and j.to_ip >=314566706 )) and ((j.from_date <= 1739988326 and j.to_date >= 1739988326 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 11614) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314566706 and j.to_ip >=314566706 )) and ((j.from_date <= 1739988326 and j.to_date >= 1739988326 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 11614) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314566706 and j.to_ip >=314566706 )) and ((j.from_date <= 1739988326 and j.to_date >= 1739988326 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 11614)
      840μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2297
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314566706 and j.to_ip >=314566706 )) and ((j.from_date <= 1739988326 and j.to_date >= 1739988326 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 112641) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314566706 and j.to_ip >=314566706 )) and ((j.from_date <= 1739988326 and j.to_date >= 1739988326 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 112641) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 314566706 and j.to_ip >=314566706 )) and ((j.from_date <= 1739988326 and j.to_date >= 1739988326 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 112641)
      830μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2329
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `first_page` < '33' and is_uploaded = 1 and issue_id = 11614 order by cast(first_page as SIGNED) desc limit 1
      680μsalphaeurekaselec_live_10_06_2022Article.php#1819
      Bindings
      • 0: 33
      Backtrace
      • 14. app/Models/Article.php:1819
      • 15. app/Http/Controllers/ArticleController.php:2470
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `last_page` > '39' and is_uploaded = 1 and issue_id = 11614 order by cast(first_page as SIGNED) asc limit 1
      640μsalphaeurekaselec_live_10_06_2022Article.php#1831
      Bindings
      • 0: 39
      Backtrace
      • 14. app/Models/Article.php:1831
      • 15. app/Http/Controllers/ArticleController.php:2472
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `language_id` from `multilanguage` where `short_code` = 'en'
      160μsalphaeurekaselec_live_10_06_2022ArticleController.php#2497
      Bindings
      • 0: en
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2497
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1
      220μsalphaeurekaselec_live_10_06_2022MultiLanguage.php#23
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/MultiLanguage.php:23
      • 14. app/Http/Controllers/ArticleController.php:2498
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `id` from `multilanguage_article` where `article_id` = 112641 limit 1
      2.49msalphaeurekaselec_live_10_06_2022ArticleController.php#2506
      Bindings
      • 0: 112641
      Backtrace
      • 16. app/Http/Controllers/ArticleController.php:2506
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 118 and `b`.`banner_from_date` <= 1739988326 and `b`.`banner_to_date` >= 1739988326 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.14msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 118
      • 3: 1739988326
      • 4: 1739988326
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 118 and `b`.`banner_from_date` <= 1739988326 and `b`.`banner_to_date` >= 1739988326 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.34msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 118
      • 3: 1739988326
      • 4: 1739988326
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='4fe164756134b9df9d61f804215da9d4'
      250μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\MultiLanguage
    1MultiLanguage.php#?
        _token
        JcWxAHxuBdmw12VYQCT2PcsdWWL1GcKexpIwco9p
        uc_cart_id
        4fe164756134b9df9d61f804215da9d4
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/article/112641" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /article/112641
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:9 [ "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6IlVTVnFINGh3eFV5ZlowZzFJWmJkS0E9PSIsInZhbHVlIjoiaU1rL0wyVElVVjVzc282T3d3Zngyc1FJZ0haeVBuQ0hwbUI5U2pkTFNjTT0iLCJtYWMiOiI2MDU3Nzc4NTY3YTM0ZjNjZTI1ODAwNTM1MTcyNTM5MTU1ZDhlYmM2NzQxYjJlOWY4MjU4MDgwYzBlZGNjMWVmIiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6IlVTVnFINGh3eFV5ZlowZzFJWmJkS0E9PSIsInZhbHVlIjoiaU1rL0wyVElVVjVzc282T3d3Zngyc1FJZ0haeVBuQ0hwbUI5U2pkTFNjTT0iLCJtYWMiOiI2MDU3Nzc4NTY3YTM0" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] "connection" => array:1 [ 0 => "keep-alive" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] ]
        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Wed, 19 Feb 2025 18:05:26 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6Impvck1HME9tb0RRV3ZFdldWT1lic0E9PSIsInZhbHVlIjoiNHQxOXl4OXhUeEdVSWo3RkxXWkx0UU51Y2FtZnNBb0dKeGQ0T2NHMC9tQjlad0RpcTd5aHgrOVFBQUhiMDNRV1RxTWxCbW5na21HVXVObWlTOVpRNzJEYkdndU5pMm02Q3B2TUxHa0NQU3NieUxsYnFjdHZjbkRUUkJtZWNmZm8iLCJtYWMiOiJkNmE3MWM3Y2I2YzMyMjBmNTNjYTliYWQ0NTAzNzM3Y2Q5YjAyNjBkODBiYjBiYjIzZTI2Zjc5ZTJhZTU1ZTUzIiwidGFnIjoiIn0%3D; expires=Sat, 22 Feb 2025 06:05:27 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6Impvck1HME9tb0RRV3ZFdldWT1lic0E9PSIsInZhbHVlIjoiNHQxOXl4OXhUeEdVSWo3RkxXWkx0UU51Y2FtZnNBb0dKeGQ0T2NHMC9tQjlad0RpcTd5aHgrOVFBQUhiMDNRV1RxTWxCb" 1 => "alphaeurekaselectnet_session=eyJpdiI6Im9DOENJaVYrL3RxRHNnQ1JQbndXZmc9PSIsInZhbHVlIjoiTmlncUpaWEhnY3E3WEY1aEV2UHZNemNQWkFGOFF3bmhFQ0tpc2poUXZtcHNlZnRKRGVqTDZFL2l4ZDA3cXFueEJVV045SlZUN3pLMnZpT1hYTUZaMER4WkxrdmRNZEdKWmsyRFo0QXQvTjZjV01UY2tuUjZ1V0RvS1ZiSnkxVmUiLCJtYWMiOiI1ZTRiOWY4YmJlMGUxNDcwYWVlMTA0ODI1YzExMGQxOWJkMjg4YjE5OWE4YTk4ZTFmMmFmZWFjYmY5NTJlYmQyIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6Im9DOENJaVYrL3RxRHNnQ1JQbndXZmc9PSIsInZhbHVlIjoiTmlncUpaWEhnY3E3WEY1aEV2UHZNemNQWkFGOFF3bmhFQ0tpc2poUXZtcHNlZnRKRGVqTDZFL2l" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6Impvck1HME9tb0RRV3ZFdldWT1lic0E9PSIsInZhbHVlIjoiNHQxOXl4OXhUeEdVSWo3RkxXWkx0UU51Y2FtZnNBb0dKeGQ0T2NHMC9tQjlad0RpcTd5aHgrOVFBQUhiMDNRV1RxTWxCbW5na21HVXVObWlTOVpRNzJEYkdndU5pMm02Q3B2TUxHa0NQU3NieUxsYnFjdHZjbkRUUkJtZWNmZm8iLCJtYWMiOiJkNmE3MWM3Y2I2YzMyMjBmNTNjYTliYWQ0NTAzNzM3Y2Q5YjAyNjBkODBiYjBiYjIzZTI2Zjc5ZTJhZTU1ZTUzIiwidGFnIjoiIn0%3D; expires=Sat, 22-Feb-2025 06:05:27 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6Impvck1HME9tb0RRV3ZFdldWT1lic0E9PSIsInZhbHVlIjoiNHQxOXl4OXhUeEdVSWo3RkxXWkx0UU51Y2FtZnNBb0dKeGQ0T2NHMC9tQjlad0RpcTd5aHgrOVFBQUhiMDNRV1RxTWxCb" 1 => "alphaeurekaselectnet_session=eyJpdiI6Im9DOENJaVYrL3RxRHNnQ1JQbndXZmc9PSIsInZhbHVlIjoiTmlncUpaWEhnY3E3WEY1aEV2UHZNemNQWkFGOFF3bmhFQ0tpc2poUXZtcHNlZnRKRGVqTDZFL2l4ZDA3cXFueEJVV045SlZUN3pLMnZpT1hYTUZaMER4WkxrdmRNZEdKWmsyRFo0QXQvTjZjV01UY2tuUjZ1V0RvS1ZiSnkxVmUiLCJtYWMiOiI1ZTRiOWY4YmJlMGUxNDcwYWVlMTA0ODI1YzExMGQxOWJkMjg4YjE5OWE4YTk4ZTFmMmFmZWFjYmY5NTJlYmQyIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6Im9DOENJaVYrL3RxRHNnQ1JQbndXZmc9PSIsInZhbHVlIjoiTmlncUpaWEhnY3E3WEY1aEV2UHZNemNQWkFGOFF3bmhFQ0tpc2poUXZtcHNlZnRKRGVqTDZFL2l" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "JcWxAHxuBdmw12VYQCT2PcsdWWL1GcKexpIwco9p" "uc_cart_id" => "4fe164756134b9df9d61f804215da9d4" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/article/112641" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-19 18:05:27GET/article/112641614371