Evaluation of Salivary Helicobacter pylori, Calcium, Urea, pH and Flow Rate in Hemodialysis Patients

Title:Evaluation of Salivary Helicobacter pylori, Calcium, Urea, pH and Flow Rate in Hemodialysis Patients

Volume: 21 Issue: 7

Author(s): Farshad Teimoori, Mehrdad Hajilooei, Hamidreza Abdolsamadi, Khadijeh Eslami, Abbas Moghimbeigi and Fatemeh Ahmadi- Motamayel*

Affiliation:

• Research Center for Molecular Medicine and Dental Research Center, Department of Oral medicine, Hamadan University of Medical Science, Hamadan,Iran

Keywords: calcium, chronic renal failure, Helicobacter pylori, saliva, urea.

Abstract:

Background: Helicobacter pylori infection is identified as a major cause of stomach ulcers, chronic inflammation and gastric cancer in hemodialysis patients. Dialysis also leads to changes in the composition and flow of saliva.

Objective: The aim of this study was to investigate the salivary Helicobacter pylori infection, Calcium, Urea, pH and flow rate in hemodialysis patients in comparison to the healthy control group.

Methods: In this study 48 hemodialysis patients and 48 healthy subjects were compared. The prevalence of Helicobacter pylori infection was determined by PCR method. Calcium, Urea, pH, salivary flow and gastrointestinal complications in both groups were measured and compared.

Results: Prevalence of Helicobacter pylori was 12.48 (25.0%) in the study group and 2.48 (4.2%) in the controls (P=0.000). Urea, calcium and pH were significantly higher in the patient group. The mean salivary flow rate decreased significantly in the patient group. 58.3% of patients group had gastrointestinal complications.

Conclusion: Oral cavity as an important external source of Helicobacter pylori may play an important role in gastrointestinal problems of hemodialysis patients. Helicobacter pylori, Urea, calcium and pH were significantly higher in the patient group. Chronic renal failure can increase pH, urea and calcium in saliva and decrease salivary flow rate.

Cite this article as:

Teimoori Farshad , Hajilooei Mehrdad , Abdolsamadi Hamidreza , Eslami Khadijeh , Moghimbeigi Abbas and Ahmadi- Motamayel Fatemeh*, Evaluation of Salivary Helicobacter pylori, Calcium, Urea, pH and Flow Rate in Hemodialysis Patients, Infectious Disorders - Drug Targets 2021; 21 (7) : e160921189262 . https://dx.doi.org/10.2174/1871526520666201218154530