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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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General Research Article

左西孟旦对帕金森氏病两种不同啮齿动物模型的影响

卷 17, 期 11, 2020

页: [1043 - 1051] 页: 9

弟呕挨: 10.2174/1567205017666201218102724

价格: $65

摘要

背景：帕金森氏病（PD）是一种常见的神经退行性疾病，其特征是与多巴胺水平缺乏有关的运动症状，以及与阿尔茨海默氏病期间表现出的自然症状相似的认知症状。另一方面，左西孟旦是一种钙敏化剂和磷酸二酯酶抑制剂，具有神经保护，记忆增强和抗凋亡的作用。 目的：在当前的研究中，在两种帕金森氏病动物模型中研究了左西孟旦的可能的保护作用。 方法：将脑内注射6-羟基多巴胺（6-OHDA）和直接注射脂多糖（LPS）到黑质中均作为诱发帕金森氏样行为的模型。左西孟旦（每周一次腹膜内注射12μg/ kg）在损伤动物的前7天或后2天开始。损伤后第14天，对动物进行阿扑吗啡攻击，这与纹状体和酪氨酸羟化酶（TH）阳性黑质细胞中的多巴胺水平相关。 结果：结果表明，左西孟旦在6-OHDA损伤前7天给药，但不是在2天后给药，可恢复阿扑吗啡激发试验的转数，纹状体中的多巴胺水平和TH阳性黑质细胞。在PD的LPS模型中，阿波吗啡攻击试验的转数，纹状体中的多巴胺水平和TH阳性黑质细胞在损伤前7天和损伤后2天给药后均得到恢复。 结论：左西孟旦似乎为PD提供了有前途的潜在临床价值。

关键词: 帕金森氏病，6-OHDA引起的旋转，左旋糖酐，LPS，免疫染色，纹状体。

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