乳腺癌的靶向信号通路JAK/STAT

Title:Targeting the JAK/STAT Signaling Pathway for Breast Cancer

Volume: 28 Issue: 25

关键词: 乳腺癌，JAK/STAT通路，抑制剂，靶向治疗，疗法，STAT3二聚体。

摘要: Breast cancer is the most common malignant tumor in women worldwide. Traditional ways of treatment, including radiotherapy and endocrine therapy, for breast cancer have inevitable side effects. In recent decades, targeted therapies for breast cancer have rapidly advanced and shown a promising future. The JAK/STAT signaling pathway has been shown to play important roles in tumorigenesis, maintenance and metastasis of breast cancer. Hence, many small molecule inhibitors of JAK and STAT proteins have been developed. These inhibitors exhibit potent inhibitory effects on breast cancer in both cellular and animal models, and even some of them have already been in clinical trials. This review article discussed the JAK/STAT signal transduction pathway in the pathogenesis of breast cancer, and the potential for the application of JAK/STAT inhibitors in breast cancer treatment.

Cite this article as:

Targeting the JAK/STAT Signaling Pathway for Breast Cancer, Current Medicinal Chemistry 2021; 28 (25) . https://dx.doi.org/10.2174/0929867328666201207202012