Abstract
Foot infections, being one of the major complications, account for nearly 15% of people with diabetes, and increase their risk for amputation in lower extremities. Though various factors contribute to the development of diabetic foot infection, poor glycemic control poses a greater risk paving the way for a number of micro-organisms to colonize the wound.
In order to restore the lost granulation tissue at the ulcer site, the prime aim should not only be attaining glycemic control but also must focus on performing culture by clinically differentiating the stage of infection as well as to manage or control the infection by selecting a rational empiric antibiotic regimen, amidst the uncertainty that exists in choosing best antimicrobial therapy in emerging multi-drug resistance worldwide. This review mainly analyzes that although among the existence of various undefined microbiome being prevalent in causing diabetic foot infections, how the current trend of antibiotics in use aids in treating foot infections in diabetes.Keywords: Diabetic foot infections, matrix metallo-proteinases, wagner classification, methicillin resistant Staphylococcusaureus, antimicrobial therapy, microbiome.
Graphical Abstract
Infectious Disorders - Drug Targets
Title:A Review on the Current Principles of Antibiotic Therapy for Diabetic Foot Infection
Volume: 21 Issue: 5
Author(s): Sainath Prasanna Bharathi and Sathesh Kumar Sukumaran*
Affiliation:
- School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Chennai 600117, Tamilnadu,India
Keywords: Diabetic foot infections, matrix metallo-proteinases, wagner classification, methicillin resistant Staphylococcusaureus, antimicrobial therapy, microbiome.
Abstract:
Foot infections, being one of the major complications, account for nearly 15% of people with diabetes, and increase their risk for amputation in lower extremities. Though various factors contribute to the development of diabetic foot infection, poor glycemic control poses a greater risk paving the way for a number of micro-organisms to colonize the wound.
In order to restore the lost granulation tissue at the ulcer site, the prime aim should not only be attaining glycemic control but also must focus on performing culture by clinically differentiating the stage of infection as well as to manage or control the infection by selecting a rational empiric antibiotic regimen, amidst the uncertainty that exists in choosing best antimicrobial therapy in emerging multi-drug resistance worldwide. This review mainly analyzes that although among the existence of various undefined microbiome being prevalent in causing diabetic foot infections, how the current trend of antibiotics in use aids in treating foot infections in diabetes.Export Options
About this article
Cite this article as:
Bharathi Prasanna Sainath and Sukumaran Kumar Sathesh *, A Review on the Current Principles of Antibiotic Therapy for Diabetic Foot Infection, Infectious Disorders - Drug Targets 2021; 21 (5) : e270421188440 . https://dx.doi.org/10.2174/1871526520999201126203738
DOI https://dx.doi.org/10.2174/1871526520999201126203738 |
Print ISSN 1871-5265 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3989 |
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