摘要
背景:肠道纤维化和随后的狭窄是炎性肠病(IBD)的重要负担。在确定最佳治疗策略(医学抗炎治疗,内窥镜扩张,手术)时,检测和评估纤维化程度对克罗恩病(CD)的狭窄至关重要。超声弹性成像技术(USE)是一项无创技术,已在IBD领域提出,用于评估肠硬度作为肠纤维化的生物标记。目的:本综述旨在探讨超声弹性成像技术在评估肠纤维化中的能力和当前作用。结果与结论:有关IBD中USE的数据是通过小样本量的试验性和概念验证研究提供的。研究的第一类USE是应变弹性成像,而最近引入了剪切波弹性成像。尽管研究方法的异质性,但已证明USE能够评估狭窄CD患者的肠道纤维化。但是,在将这种技术引入当前实践之前,需要对更大的样本量进行进一步的研究。此外,均质参数的使用,可重复性的评估以及有效阈值的识别也是必不可少的。
关键词: 炎症性肠病(IBD),克罗恩病(CD),超声弹性成像(USE),异质性,纤维化,治疗策略。
图形摘要
Current Drug Targets
Title:Application of Ultrasound Elastography for Assessing Intestinal Fibrosis in Inflammatory Bowel Disease: Fiction or Reality?
Volume: 22 Issue: 3
关键词: 炎症性肠病(IBD),克罗恩病(CD),超声弹性成像(USE),异质性,纤维化,治疗策略。
摘要:
Background: Intestinal fibrosis and subsequent strictures represent an important burden in inflammatory bowel disease (IBD). Both the detection and evaluation of the degree of fibrosis in stricturing Crohn’s disease (CD) are important when deciding the best therapeutic strategy (medical anti-inflammatory therapy, endoscopic dilation, surgery). Ultrasound elastography (USE) is a non-invasive technique that has been proposed in the field of IBD for evaluating intestinal stiffness as a biomarker of intestinal fibrosis.
Objective: The aim of this review is to discuss the ability and current role of ultrasound elastography in the assessment of intestinal fibrosis. Results and Conclusion: Data on USE in IBD are provided by pilot and proof-of-concept studies with small sample size. The first type of USE investigated was strain elastography, while shear wave elastography has been introduced recently. Despite the heterogeneity of the methods of the studies, USE has been proven to be able to assess intestinal fibrosis in patients with stricturing CD. However, before introducing this technique in current practice, further studies with larger sample sizes are needed. In addition, the use of homogeneous parameters, the assessment of reproducibility, and the identification of validated cut-off values are essential.
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Cite this article as:
Application of Ultrasound Elastography for Assessing Intestinal Fibrosis in Inflammatory Bowel Disease: Fiction or Reality?, Current Drug Targets 2021; 22 (3) . https://dx.doi.org/10.2174/1389450121666201119142919
DOI https://dx.doi.org/10.2174/1389450121666201119142919 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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