摘要
背景:肠道纤维化和随后的狭窄是炎性肠病(IBD)的重要负担。在确定最佳治疗策略(医学抗炎治疗,内窥镜扩张,手术)时,检测和评估纤维化程度对克罗恩病(CD)的狭窄至关重要。超声弹性成像技术(USE)是一项无创技术,已在IBD领域提出,用于评估肠硬度作为肠纤维化的生物标记。目的:本综述旨在探讨超声弹性成像技术在评估肠纤维化中的能力和当前作用。结果与结论:有关IBD中USE的数据是通过小样本量的试验性和概念验证研究提供的。研究的第一类USE是应变弹性成像,而最近引入了剪切波弹性成像。尽管研究方法的异质性,但已证明USE能够评估狭窄CD患者的肠道纤维化。但是,在将这种技术引入当前实践之前,需要对更大的样本量进行进一步的研究。此外,均质参数的使用,可重复性的评估以及有效阈值的识别也是必不可少的。
关键词: 炎症性肠病(IBD),克罗恩病(CD),超声弹性成像(USE),异质性,纤维化,治疗策略。
图形摘要
Current Drug Targets
Title:Application of Ultrasound Elastography for Assessing Intestinal Fibrosis in Inflammatory Bowel Disease: Fiction or Reality?
Volume: 22 Issue: 3
关键词: 炎症性肠病(IBD),克罗恩病(CD),超声弹性成像(USE),异质性,纤维化,治疗策略。
摘要:
Background: Intestinal fibrosis and subsequent strictures represent an important burden in inflammatory bowel disease (IBD). Both the detection and evaluation of the degree of fibrosis in stricturing Crohn’s disease (CD) are important when deciding the best therapeutic strategy (medical anti-inflammatory therapy, endoscopic dilation, surgery). Ultrasound elastography (USE) is a non-invasive technique that has been proposed in the field of IBD for evaluating intestinal stiffness as a biomarker of intestinal fibrosis.
Objective: The aim of this review is to discuss the ability and current role of ultrasound elastography in the assessment of intestinal fibrosis. Results and Conclusion: Data on USE in IBD are provided by pilot and proof-of-concept studies with small sample size. The first type of USE investigated was strain elastography, while shear wave elastography has been introduced recently. Despite the heterogeneity of the methods of the studies, USE has been proven to be able to assess intestinal fibrosis in patients with stricturing CD. However, before introducing this technique in current practice, further studies with larger sample sizes are needed. In addition, the use of homogeneous parameters, the assessment of reproducibility, and the identification of validated cut-off values are essential.
Export Options
About this article
Cite this article as:
Application of Ultrasound Elastography for Assessing Intestinal Fibrosis in Inflammatory Bowel Disease: Fiction or Reality?, Current Drug Targets 2021; 22 (3) . https://dx.doi.org/10.2174/1389450121666201119142919
DOI https://dx.doi.org/10.2174/1389450121666201119142919 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Related Journals
Related Books
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Mitochondria as a Therapeutic Target in Alzheimers Disease and Diabetes
CNS & Neurological Disorders - Drug Targets Vasopressin & Oxytocin in Control of the Cardiovascular System: An Updated Review
Current Neuropharmacology The DOCA-Salt Hypertensive Rat as a Model of Cardiovascular Oxidative and Inflammatory Stress
Current Cardiology Reviews Current Proposed Mechanisms of Action of Intravenous Immunoglobulins in Inflammatory Neuropathies
Current Neuropharmacology Medicinal Chemistry of Potassium Channel Modulators: An Update of Recent Progress (2011-2017)
Current Medicinal Chemistry Calcium Channel Blockers - Benefits Upon Vascular Biology in Hypertensive Patients
Cardiovascular & Hematological Agents in Medicinal Chemistry When Cells Become a Drug. Endothelial Progenitor Cells for Cardiovascular Therapy: Aims and Reality
Recent Patents on Cardiovascular Drug Discovery Hypotensive Natural Products: Current Status
Mini-Reviews in Medicinal Chemistry Optimization of Lentiviral Vectors Generation for Biomedical and Clinical Research Purposes: Contemporary Trends in Technology Development and Applications
Current Gene Therapy Statin Treatment Non-adherence and Discontinuation: Clinical Implications and Potential Solutions
Current Pharmaceutical Design Use of Peripheral Blood Stem Cells in Tissue Engineering
Current Tissue Engineering (Discontinued) Obstructive Sleep Apnea and Hypertension: A Bidirectional Causal Relation
Current Respiratory Medicine Reviews Extracellular Vesicles in the Treatment of Parkinson’s Disease: A Review
Current Medicinal Chemistry Thresholds for Central Blood Pressures and Augmentation Indices - are They Needed and How Far are We in the Process of Their Definition?
Current Hypertension Reviews Phytotherapeutic Agents for Benign Prostatic Hyperplasia: An Overview
Mini-Reviews in Medicinal Chemistry The Impact of Old Age on Skeletal Muscle Energetics: Supply and Demand
Current Aging Science Novel Anti-Platelets in Stable Coronary Artery Disease
Current Pharmaceutical Design Targeting Microtubules to Inhibit Angiogenesis and Disrupt Tumour Vasculature:Implications for Cancer Treatment
Current Cancer Drug Targets Release of Adenosine and ATP During Ischemia and Epilepsy
Current Neuropharmacology Endothelial Remodelling and Intracellular Calcium Machinery
Current Molecular Medicine