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Research Article

石炭胺对小鼠阿尔茨海默病模型治疗作用的评价

卷 28, 期 17, 2021

发表于: 16 November, 2020

页: [3449 - 3473] 页: 25

弟呕挨: 10.2174/0929867327999201116193126

价格: $65

摘要

背景：阿尔茨海默病是主要的健康问题之一，其特征是Aβ和过度磷酸化tau蛋白的积累，这是导致广泛认知能力下降的老年斑形成的原因。许多阿尔茨海默氏病的临床诊断是在晚期做出的，那时病理变化已经进展。 目的：本研究的目的是评估天然化合物石炭胺的治疗效果，该化合物已在多项研究中显示出治疗潜力，并通过差异蛋白表达分析了解其在分子水平上的作用机制。 方法：研究人员给12个月大的5xFAD小鼠注射了利可拉明和加兰他明(FDA批准用于轻度至中度AD治疗的药物)。采用Morris水迷宫法、免疫组化法和无标记差异蛋白表达法观察化合物的作用。 结果：在这里，我们通过行为测试证明了认知衰退的逆转和Aβ斑块的清除。蛋白质组学分析提供了在皮质、海马和小脑部分有统计学意义的蛋白质扰动的深入信息，以假设斑块形成的可能清除机制和逆转认知衰退的分子机制的转基因小鼠模型。生物信息学分析显示，改变的分子途径，可以与逆转认知衰退后观察到，而不是加兰他敏。在这里，我们通过行为测试证明了认知衰退的逆转和Aβ斑块的清除。蛋白质组学分析提供了在皮质、海马和小脑部分有统计学意义的蛋白质扰动的深入信息，以假设斑块形成的可能清除机制和逆转认知衰退的分子机制的转基因小鼠模型。生物信息学分析显示，改变的分子途径，可以与逆转认知衰退后观察到，而不是加兰他敏。 结论：在疾病进展的晚期阶段，利可拉明显示出阻止和逆转认知衰退的治疗潜力，并为阿尔茨海默病的治疗带来了巨大的希望。

关键词: 阿尔茨海默病，5xFAD，石蒜胺，加兰他明，无标签蛋白质组学，神经退行性变

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