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Current Diabetes Reviews

Editor-in-Chief

ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

Review Article

Understanding the Concept of Chronotherapeutics in the Management of Diabetes Mellitus

Author(s): Shilpi Kashyap, Rajni Bala* and Tapan Behl

Volume 17, Issue 5, 2021

Published on: 22 October, 2020

Article ID: e221020187106 Pages: 7

DOI: 10.2174/1573399816666201022120825

Price: $65

Abstract

The circadian rhythms have been controlled with the aid of a circadian clock in the hypothalamus region, which is known as the suprachiasmatic nucleus. Chronotherapeutics, a branch of pharmacotherapeutics, plays a mandatory role in the treatment of various disorders, such as delivering the drug in the correct schedule, correct site, and correct extent and provides benefit to the patients. The chronopharmacological aspects are very much important in the treatment of diabetes mellitus during daytime as the patients’ timing of daily activities of body and medicine treatment has an impact on the increase in the glucose levels in the blood. This leads to the fact that the increased risk of obesity and diabetes gets worse, ultimately increasing the rates of cardiovascular diseases and deaths. According to a medical saviour who works on the problems related to diabetes, the level of glucose in plasma changes independently as regard to eating habits and use of insulin and medicines. People suffering from dawn phenomenon are difficult to manage, hence, the basic aim is to detect the functioning of the biological clock of human body and its chronotherapeutic effect on human beings that increases the therapeutic effects and reduces side effects. Keeping these points in mind, an attempt has been made in the present review to discuss the role of chronotherapy in the management of diabetes, various techniques used in formulation and design of chronotherapeutic drug delivery systems and regulatory issues related to chronotherapeutics.

Keywords: Chronotherapeutics, diabetes, glucose responsive, cardiovascular, insulin, circadian rhythms.


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