摘要
血栓形成是世界范围内最关注的疾病,因为它与与心血管系统有关的威胁生命的疾病有关。这种疾病每年影响1000名成人中的1名,而四分之一因血栓形成而死亡,并且随着年龄的增长而增加。主要结果被认为是复发,由于市售抗凝剂引起的出血以及死亡。与可用的抗血栓形成药物相关的副作用是一个值得关注的问题。因此,有必要发现和开发一种简易的获益风险分析药物,因此,在寻找替代方法来治疗血栓形成时,海洋资源已被用作有前途的治疗剂。他们表明存在硫酸化的岩藻聚糖/半乳聚糖,纤溶蛋白酶,二萜,糖胺聚糖,糖苷,肽,氨基酸,固醇,多糖,多酚,维生素和矿物质。在这些海洋资源中,发现许多化学物质具有抗血栓形成作用。本文综述了从海藻,海绵,贻贝和海参中获得的抗血栓形成剂的最新发现,以及它们的作用机理以及其提取工艺,制备方法和应用方面的专利。此外,本文以作者对海洋药物的见解作为结束,海洋药物具有广阔的前景。
关键词: 血栓形成,海洋衍生分子,岩藻糖基化硫酸软骨素,糖胺聚糖,藻类,海绵,海参,贻贝,心血管,专利。
图形摘要
Current Drug Targets
Title:A Review on Molecular Mechanisms and Patents of Marine-derived Anti-thrombotic Agents
Volume: 22 Issue: 3
关键词: 血栓形成,海洋衍生分子,岩藻糖基化硫酸软骨素,糖胺聚糖,藻类,海绵,海参,贻贝,心血管,专利。
摘要: Thrombosis is a condition of major concern worldwide as it is associated with life-threatening diseases related to the cardiovascular system. The condition affects 1 in 1000 adults annually, whereas 1 in 4 dies due to thrombosis, and this increases as the age group increases. The major outcomes are considered to be a recurrence, bleeding due to commercially available anti-coagulants, and deaths. The side effects associated with available anti-thrombotic drugs are a point of concern. Therefore, it is necessary to discover and develop an improvised benefit-risk profile drug, therefore, in search of alternative therapy for the treatment of thrombosis, marine sources have been used as promising treatment agents. They have shown the presence of sulfated fucans/galactans, fibrinolytic proteases, diterpenes, glycosaminoglycan, glycoside, peptides, amino acids, sterols, polysaccharides, polyphenols, vitamins, and minerals. Out of these marine sources, many chemicals were found to have anti-thrombotic activities. This review focuses on the recent discovery of anti-thrombotic agents obtained from marine algae, sponges, mussels, and sea cucumber, along with their mechanism of action and patents on its extraction process, preparation methods, and their applications. Further, the article concludes with the author's insight related to marine drugs, which have a promising future.
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Cite this article as:
A Review on Molecular Mechanisms and Patents of Marine-derived Anti-thrombotic Agents, Current Drug Targets 2021; 22 (3) . https://dx.doi.org/10.2174/1389450121666201020151927
DOI https://dx.doi.org/10.2174/1389450121666201020151927 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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