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Review Article

草药资源治疗对抗进行性和退行性神经系统失调的帕金森氏病

卷 22, 期 6, 2021

发表于: 13 October, 2020

页: [609 - 630] 页: 22

弟呕挨: 10.2174/1389450121999201013155202

价格: $65

摘要

帕金森病是一种最常见的成人发病疾病，慢性神经退行性变导致黑质多巴胺能神经元逐渐丧失，导致纹状体多巴胺水平降低，导致震颤、肌强直和运动障碍。遗传学和环境因素被认为是帕金森病发病的原因。帕金森病的确切发病机制相当复杂，目前的抗帕金森病治疗在临床上尚不充分。综合研究表明，人参、姜黄素、南非醉茄（印度人参）、黄芩素等天然产物可用于本病的对症治疗。这些天然产物表现出的神经保护作用主要是由于它们能够增加纹状体中的多巴胺水平，管理氧化应激，线粒体功能障碍，谷胱甘肽水平，清除α- synuclein的聚集，诱导自噬，减少促炎细胞因子和脂质过氧化。本文综述了科学家进行的各种天然产物研究，以确定天然产物(包括代谢物提取物和纯代谢物)作为辅助神经保护剂的作用。

关键词: 帕金森病，多巴胺，天然产物，草药，天然神经保护剂，神经退行性变

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