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Current Drug Metabolism

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ISSN (Print): 1389-2002
ISSN (Online): 1875-5453

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Systematic Review Article

The Current Application of LC-MS/MS in Pharmacokinetics of Traditional Chinese Medicines (Recent Three Years): A Systematic Review

Author(s): Yang Wang, Lu Zhang, Shuang Gu, Zhaorui Yin, Zhe Shi, Ping Wang* and Changhua Xu*

Volume 21, Issue 12, 2020

Page: [969 - 978] Pages: 10

DOI: 10.2174/1389200221666201009142418

Price: $65

Abstract

Background: With significant clinical effects, traditional Chinese medicine (TCM) has been attracting increasing interest of the world’s scientific community. However, TCM contains immense amounts of chemical components. It is a great challenge to objectively evaluate the correlation between the in vivo process and the therapeutic effect of TCM. The purpose of this systematic review was to summarize the recent investigation (from 2017 to 2019) on preclinical pharmacokinetics (PK) of TCM via liquid chromatography coupled with mass spectrometry (LC-MS/MS).

Methods: We reviewed the published articles regarding the PK of TCM by LC-MS/MS. In addition, we summarized information on PK parameter of bioactive components, single herb and traditional Chinese medicine prescriptions.

Results: The vast majority of literature on preclinical PK of TCM uses single oral administration, the biological matrix is mostly rat plasma, and the main PK parameters include AUC, Cmax, Tmax and T1/2, etc.

Conclusion: Although LC-MS/MS can be used for high-throughput analysis, the characterization of in vivo processes of TCM still has a long way. With the advantages of high sensitivity, high specificity and simple operation, the increasingly mature LC-MS/MS technology will play an important role in the PK study of TCM.

Keywords: Traditional Chinese medicine, LC-MS/MS, pharmacokinetics, quantitative analysis, bioactive components, pharmacodynamic material basis.

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[1]
Tian, P. Convergence: where West meets East. Nature, 2011, 480(7378), S84-S86.
[http://dx.doi.org/10.1038/480S84a] [PMID: 22190086]
[2]
Currie, G.M. Pharmacology, part 2: introduction to pharmacokinetics. J. Nucl. Med. Technol., 2018, 46(3), 221-230.
[http://dx.doi.org/10.2967/jnmt.117.199638] [PMID: 29724803]
[3]
Normile, D. Asian medicine. The new face of traditional Chinese medicine. Science, 2003, 299(5604), 188-190. [J
[http://dx.doi.org/10.1126/science.299.5604.188] [PMID: 12522228]
[4]
van der Greef, J.; Martin, S.; Juhasz, P.; Adourian, A.; Plasterer, T.; Verheij, E.R.; McBurney, R.N. The art and practice of systems biology in medicine: mapping patterns of relationships. J. Proteome Res., 2007, 6(4), 1540-1559.
[http://dx.doi.org/10.1021/pr0606530] [PMID: 17373844]
[5]
Wang, X.J. Studies on serum pharmacochemistry of traditional Chinese medicine, world science and technology: modernization of traditional. Chin. Med., 2002, 4(2), 1-4.
[6]
Jiang, P.; Liu, R.; Dou, S.; Liu, L.; Zhang, W.; Chen, Z.; Xu, R.; Ding, J. Analysis of the constituents in rat plasma after oral administration of Shexiang Baoxin pill by HPLC-ESI-MS/MS. Biomed. Chromatogr., 2009, 23(12), 1333-1343.
[http://dx.doi.org/10.1002/bmc.1258] [PMID: 19517427]
[7]
Wei, W.; Yu, Y.; Wang, X.; Yang, L.; Zhang, H.; Ji, H.; Li, Z.; Hou, J.; Wu, W.; Guo, D. Simultaneous determination of Bufalin and its nine metabolites in rat plasma for characterization of metabolic profiles and pharmacokinetic study by LC(-)MS/MS. Molecules, 2019, 24(9), 1-15.
[http://dx.doi.org/10.3390/molecules24091662]
[8]
Fan, J.; de Lannoy, I.A. Pharmacokinetics. Biochem. Pharmacol., 2014, 87(1), 93-120.
[http://dx.doi.org/10.1016/j.bcp.2013.09.007] [PMID: 24055064]
[9]
Nnane, I.P.; Xu, Z.; Zhou, H.; Davis, H.M. Non-clinical pharmacokinetics, prediction of human pharmacokinetics and first-in-human dose selection for CNTO 5825, an anti-interleukin-13 monoclonal antibody. Basic Clin. Pharmacol. Toxicol., 2015, 117(4), 219-225.
[http://dx.doi.org/10.1111/bcpt.12391] [PMID: 25683750]
[10]
Betts, A.; Keunecke, A.; van Steeg, T.J.; van der Graaf, P.H.; Avery, L.B.; Jones, H.; Berkhout, J. Linear pharmacokinetic parameters for monoclonal antibodies are similar within a species and across different pharmacological targets: a comparison between human, cynomolgus monkey and hFcRn Tg32 transgenic mouse using a population-modeling approach. MAbs, 2018, 10(5), 751-764.
[http://dx.doi.org/10.1080/19420862.2018.1462429] [PMID: 29634430]
[11]
Andrade, E.L.; Bento, A.F.; Cavalli, J.; Oliveira, S.K.; Schwanke, R.C.; Siqueira, J.M.; Freitas, C.S.; Marcon, R.; Calixto, J.B. Non-clinical studies in the process of new drug development-Part II: good laboratory practice, metabolism, pharmacokinetics, safety and dose translation to clinical studies. Braz. J. Med. Biol. Res., 2016, 49(12)e5646
[http://dx.doi.org/10.1590/1414-431x20165646] [PMID: 27982281]
[12]
Wang, J.; Yu, X.; Zhang, L.; Wang, L.; Peng, Z.; Chen, Y. The pharmacokinetics and tissue distribution of curcumin and its metabolites in mice. Biomed. Chromatogr., 2018, 32(9)e4267
[http://dx.doi.org/10.1002/bmc.4267] [PMID: 29689635]
[13]
Zhou, Mengying H.X.; Wang, Y. Analysis of pharmacokinetics of sanguisorbin II in rats by UPLC-MS/MS. Chinese J. of Exp. Prescriptions, 2018, 24(21), 86-90.
[14]
Liu, X.; Cong, L.; Wang, C.; Li, H.; Zhang, C.; Guan, X.; Liu, P.; Xie, Y.; Chen, J.; Sun, J. Pharmacokinetics and distribution of schisandrol A and its major metabolites in rats. Xenobiotica, 2019, 49(3), 322-331.
[http://dx.doi.org/10.1080/00498254.2017.1418543] [PMID: 29251086]
[15]
Xiao-liang, Z.; Tao, L.; Yang, L.; Mei-yu, Z.; Yue, C.; Ying, Z.; Dan-dan, S.; Zhi-guo, W.; Dan-qiou, W. Pharmacokinetic analysis of sinomenine based on automatic blood collection system and hplc-qqq-ms. Chinese J. of Exp. Prescriptions, 2015, 14, 66-70.
[16]
Ding, Y.; Ju, Z.; Ma, C. A validated LC-MS/MS method for the determination of specnuezhenide and salidroside in rat plasma and its application to a pharmacokinetic study. Biomed. Chromatogr., 2018, 32(12)e4353
[http://dx.doi.org/10.1002/bmc.4353] [PMID: 30062793]
[17]
Liu, S-G.; Dai, X-J.; Zhong, D-F.; Zhang, C-F. Identification of metabolites and pharmacokinetics of mogrol in rat plasma. Acta Pharm. Sin., 2017, 52(9), 1452-1457.
[18]
Bai, Junqi. H.J.; Wen, X.; Jing, Z.; Lu, G.; Huang, Z.; Qiu, X. Study on pharmacokinetics of dendrobine in rats by LC-MS/MS, World traditional. Chin. Med., 2019, 14, 2272-2275.
[19]
Fu, R.; Liu, J.; Xue, Y.; Zhang, Z.; Song, R. Effects of animal strain, dose, and cotreatment with Saikosaponin b2 on the pharmacokinetics of Saikosaponin a in rats. Eur. J. Drug Metab. Pharmacokinet., 2019, 44(6), 827-836.
[http://dx.doi.org/10.1007/s13318-019-00569-5] [PMID: 31317503]
[20]
Xie Yao, Z.N. Pharmacokinetic study on the main component of hyssop in Pearl lotus. J. SYMC., 2018, 4, 332-335.
[21]
Liu, Y.; Chen, L.; Cai, W.; Zhao, L.L.; Mo, Z.X. Use of an UHPLC-MS/MS method for determination of kuraridin and characterization of its metabolites in rat plasma after oral administration. Molecules, 2018, 23(2), 1-12.
[http://dx.doi.org/10.3390/molecules23020132] [PMID: 29364156]
[22]
Wang, C.; Gu, D.D.; Wang, Y.; Han, X.C. [Pharmacokinetics of gypenoside XVII in rats] Zhongguo Zhongyao Zazhi, 2017, 42(4), 783-788.
[PMID: 28959853]
[23]
Zhang , Zhe T.Y.; Ziyan, L.V. Pharmacokinetic behavior and metabolites of ginsenoside Rb2 in rats. Anal. Chem., 2017, 02, 50-57.
[24]
Hu, N.X.; Chen, M.; Liu, Y.S.; Shi, Q.; Yang, B.; Zhang, H.C.; Cheng, P.; Tang, Q.; Liu, Z.Y.; Zeng, J.G. Pharmacokinetics of sanguinarine, chelerythrine, and their metabolites in broiler chickens following oral and intravenous administration. J. Vet. Pharmacol. Ther., 2019, 42(2), 197-206.
[http://dx.doi.org/10.1111/jvp.12729] [PMID: 30350369]
[25]
Xiong, K.; Ju, Z.; Zhang, T.; Wang, Z.; Han, H. Metabolic profiles and pharmacokinetics of picroside I in rats by liquid chromatography combined with electrospray ionization tandem mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2018, 1095, 157-165.
[http://dx.doi.org/10.1016/j.jchromb.2018.07.034] [PMID: 30077096]
[26]
Su, M.; Dong, C.; Wan, J.; Zhou, M. Pharmacokinetics, tissue distribution and excretion study of trans-resveratrol-3-O-glucoside and its two metabolites in rats. Phytomedicine, 2019, 58152882
[http://dx.doi.org/10.1016/j.phymed.2019.152882] [PMID: 30901659]
[27]
Tanimura, Y.; Yoshida, M.; Ishiuchi, K.; Ohsawa, M.; Makino, T. Neoline is the active ingredient of processed aconite root against murine peripheral neuropathic pain model, and its pharmacokinetics in rats. J. Ethnopharmacol., 2019, 241111859
[http://dx.doi.org/10.1016/j.jep.2019.111859] [PMID: 30974202]
[28]
Zhang, J.Q.; Zhao, C.C.; Yang, Q.Y.; Liang, S.; Wu, F.; Ma, B.L.; Feng, Y. Pharmacokinetics, bioavailability and tissue distribution studies of rhodojaponin III in mice using QTRAP LC-MS/MS. Biomed. Chromatogr., 2019, 33(11)e4649
[http://dx.doi.org/10.1002/bmc.4649] [PMID: 31301694]
[29]
Yan, P.; Zhang, L.; Peng, C.; Zhang, R. Pharmacokinetics and tissue distribution of crotonoside. Xenobiotica, 2018, 48(1), 28-36.
[http://dx.doi.org/10.1080/00498254.2016.1276311] [PMID: 28100102]
[30]
Wen, Y.; Huo, S.; Zhang, W.; Xing, H.; Qi, L.; Zhao, D.; Li, N.; Xu, J.; Yan, M.; Chen, X. Pharmacokinetics, biodistribution, excretion and plasma protein binding studies of acteoside in rats. Drug Res. (Stuttg.), 2016, 66(3), 148-153.
[PMID: 26241371]
[31]
Li, Z.F.; Zhou, M.Y.; Tan, T.; Zhong, C.C.; Wang, Q.; Pan, L.L.; Luo, Y.Y.; Yang, S.L.; Feng, Y.L.; Ouyang, H. A sample and sensitive HPLC-MS/MS method for simultaneous determination of Ziyuglycoside I and its metabolite Ziyuglycoside II in rat pharmacokinetics. Molecules, 2018, 23(3), 1-14.
[http://dx.doi.org/10.3390/molecules23030543] [PMID: 29495641]
[32]
Dai, Y.J.; Chen, X.L.; Tang, H.Y.; Deng, X.Y.; Xie, L. Comparison of different administration routes of saikosaponin in plasma pharmacokinetics and brain pharmacokinetics. Zhongguo Zhongyao Zazhi, 2017, 42(14), 2767-2772.
[PMID: 29098835]
[33]
Zhong, R.; Yu, Y.; Zheng, Y.; Chen, W.; Zhou, G.; Ding, J.; Yuan, M. A simple and selective UHPLC-MS/MS method for quantification of plantagoguanidinic acid in rat plasma and its application to a pharmacokinetic study. Biomed. Chromatogr., 2017, 31(8), 1-24.
[http://dx.doi.org/10.1002/bmc.3929] [PMID: 28054363]
[34]
Qian, J.; Xie, F.; Shi, Y.; Li, J.; Zhang, L.; Li, Y.; Guo, F.; Wang, R. Pharmacokinetic and metabolism studies of bavachinin through ultra-high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. Biomed. Chromatogr., 2018, 32(10)e4293
[http://dx.doi.org/10.1002/bmc.4293] [PMID: 29782651]
[35]
Huang, M.C.; Hsueh, T.Y.; Cheng, Y.Y.; Lin, L.C.; Tsai, T.H. Pharmacokinetics and biliary excretion of fisetin in rats. J. Agric. Food Chem., 2018, 66(25), 6300-6307.
[http://dx.doi.org/10.1021/acs.jafc.8b00917] [PMID: 29862816]
[36]
Gbylik-Sikorska, M.; Gajda, A.; Burmańczuk, A.; Grabowski, T.; Posyniak, A. Development of a UHPLC-MS/MS method for the determination of quercetin in milk and its application to a pharmacokinetic study. J. Vet. Res. (Pulawy), 2019, 63(1), 87-91.
[http://dx.doi.org/10.2478/jvetres-2019-0013] [PMID: 30989139]
[37]
Yang, G.; Zhang, C.; Hu, P.; Zhu, M.; Hu, M.; Gao, S. An UPLC-MS/MS method for quantifying tetrandrine and its metabolite berbamine in human blood: application to a human pharmacokinetic study. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2017, 1070, 92-96.
[http://dx.doi.org/10.1016/j.jchromb.2017.10.048] [PMID: 29100757]
[38]
Li, J.; Li, X.; Ren, Y.S.; Lv, Y.Y.; Zhang, J.S.; Xu, X.L.; Wang, X.Z.; Yao, J.C.; Zhang, G.M.; Liu, Z. Elucidation of Arctigenin pharmacokinetics and tissue distribution after intravenous, oral, hypodermic and sublingual administration in rats and beagle dogs: integration of in vitro and in vivo findings. Front. Pharmacol., 2017, 8, 376-389.
[http://dx.doi.org/10.3389/fphar.2017.00376] [PMID: 28659807]
[39]
Yu, Weibang, J.Z.; Jian, Y. Pharmacokinetics of curcumin monomer and curcumin extract in rats, Pharmacology and clinic of traditional. Chin. Med., 2018, 34, 32-35.
[40]
Li, Zhining W.Y.; Jie, Z. Determination of curcumin in rat plasma by ultra high performance liquid chromatography mass spectrometry. Henan Science, 2017, 008, 1252-1257.
[41]
Cheng, D.; Li, W.; Wang, L.; Lin, T.; Poiani, G.; Wassef, A.; Hudlikar, R.; Ondar, P.; Brunetti, L.; Kong, A.N. Pharmacokinetics, pharmacodynamics, and PKPD modeling of Curcumin in regulating antioxidant and epigenetic gene expression in healthy human volunteers. Mol. Pharm., 2019, 16(5), 1881-1889.
[http://dx.doi.org/10.1021/acs.molpharmaceut.8b01246] [PMID: 30860383]
[42]
Wang, L.S.; Shi, Z.F.; Zhang, Y.F.; Guo, Q.; Huang, Y.W.; Zhou, L.L. Effect of Xiongbing compound on the pharmacokinetics and brain targeting of tetramethylpyrazine. J. Pharm. Pharmacol., 2012, 64(11), 1688-1694.
[http://dx.doi.org/10.1111/j.2042-7158.2012.01546.x] [PMID: 23058057]
[43]
Luo, H.; Li, X.; Xiao, F.; Gu, F. [Study on pharmacokinetics of ferulic acid and paeoniflorin in Angelic-Paeonia root powder] Zhong Yao Cai, 2003, 26(3), 189-192.
[PMID: 12856471]
[44]
Yan, R.; Ko, N.L.; Ma, B.; Tam, Y.K.; Lin, G. Metabolic conversion from co-existing ingredient leading to significant systemic exposure of Z-butylidenephthalide, a minor ingredient in Chuanxiong Rhizoma in rats. Curr. Drug Metab., 2012, 13(5), 524-534.
[http://dx.doi.org/10.2174/1389200211209050524] [PMID: 22554277]
[45]
Chen, X.; Zhu, P.; Liu, B.; Wei, L.; Xu, Y. Simultaneous determination of fourteen compounds of Hedyotis diffusa Willd extract in rats by UHPLC-MS/MS method: application to pharmacokinetics and tissue distribution study. J. Pharm. Biomed. Anal., 2018, 159, 490-512.
[http://dx.doi.org/10.1016/j.jpba.2018.07.023] [PMID: 30048897]
[46]
Wang, Z.; Song, M.; Cui, B.; Ren, Y.; Zhu, W.; Yang, B.; Kuang, H. A LC-MS/MS method for simultaneous determination of seven alkaloids in rat plasma after oral administration of Phellodendri chinensis cortex extract and its application to a pharmacokinetic study. J. Sep. Sci., 2019, 42(7), 1351-1363.
[http://dx.doi.org/10.1002/jssc.201801018] [PMID: 30667161]
[47]
Chen, W.; Zheng, Y.; Yan, L.; Yuan, M.; Ouyang, L.; Li, J.; Zhou, G.; Zhong, R. Validated UHPLC-MS/MS method for simultaneous determination of four triterpene saponins from Akebia trifoliata extract in rat plasma and its application to a pharmacokinetic study. Biomed. Chromatogr., 2019, 33(10)e4585
[http://dx.doi.org/10.1002/bmc.4585] [PMID: 31099065]
[48]
Zhou, Q.L.; Zhu, D.N.; Yang, Y.F.; Xu, W.; Yang, X.W. Simultaneous quantification of twenty-one ginsenosides and their three aglycones in rat plasma by a developed UFLC-MS/MS assay: application to a pharmacokinetic study of red ginseng. J. Pharm. Biomed. Anal., 2017, 137, 1-12.
[http://dx.doi.org/10.1016/j.jpba.2017.01.009] [PMID: 28086165]
[49]
Sun, M.; Yin, Y.; Wei, J.; Chen, X.; Ouyang, H.; Chang, Y.; Gao, X.; He, J. Development and validation of a HPLC-MS/MS method for simultaneous determination of twelve bioactive compounds in Epimedium: application to a pharmacokinetic study in rats. Molecules, 2018, 23(6)E1322
[http://dx.doi.org/10.3390/molecules23061322] [PMID: 29857519]
[50]
Xu, Z.L.; Xu, M.Y.; Wang, H.T.; Xu, Q.X.; Liu, M.Y.; Jia, C.P.; Geng, F.; Zhang, N. Pharmacokinetics of eight flavonoids in rats assayed by UPLC-MS/MS after oral administration of Drynariae rhizoma extract. J. Anal. Methods Chem., 2018, 20184789196
[http://dx.doi.org/10.1155/2018/4789196] [PMID: 30662789]
[51]
Chen, S.; Li, M.; Li, Y.; Hu, H.; Li, Y.; Huang, Y.; Zheng, L.; Lu, Y.; Hu, J.; Lan, Y.; Wang, A.; Li, Y.; Gong, Z.; Wang, Y.A. UPLC-ESI-MS/MS method for simultaneous quantitation of chlorogenic acid, scutellarin, and scutellarein in rat plasma: application to a comparative pharmacokinetic study in Sham-Operated and MCAO rats after oral administration of Erigeron breviscapus Extract. Molecules, 2018, 23(7), 1-13.
[http://dx.doi.org/10.3390/molecules23071808] [PMID: 30037063]
[52]
Tao, Y.; Huang, S.; Yan, J.; Cai, B. A reliable LC-MS/MS method for the quantification of five bioactive saponins of crude and processed Bupleurum scorzonerifolium in rat plasma and its application to a pharmacokinetic study. Biomed. Chromatogr., 2019, 33(9)e4570
[http://dx.doi.org/10.1002/bmc.4570] [PMID: 31049981]
[53]
Zhang, H.; Hu, X.; Qiao, M.; Li, Y.; Cao, S.; Ding, L.; Feng, X.; Kang, N.; Zhang, D.; Qiu, F. Simultaneous determination of five isoflavones in rat plasma by LC-MS/MS: comparative pharmacokinetic characteristics of Puerariae lobatae radix in normal and type 2 diabetic rats. J. Sep. Sci., 2019, 42(16), 2592-2601.
[http://dx.doi.org/10.1002/jssc.201900341] [PMID: 31161707]
[54]
Chen, L.; Zhao, L.; Cai, W.; Shao, J.; Huang, X.; Liu, Y. An accurate and reproducible method for simultaneous determination of four flavonoids in EtOAc extracts from Sophora flavescens Ait. in rat plasma based on UHPLC Q-exactive mass spectrometry: application to a pharmacokinetics study. Biomed. Chromatogr., 2019, 33(3)e4447
[http://dx.doi.org/10.1002/bmc.4447] [PMID: 30469166]
[55]
Wang, L.; Sang, M.; Liu, E.; Banahene, P.O.; Zhang, Y.; Wang, T.; Han, L.; Gao, X. Rapid profiling and pharmacokinetic studies of major compounds in crude extract from Polygonum multiflorum by UHPLC-Q-TOF-MS and UPLC-MS/MS. J. Pharm. Biomed. Anal., 2017, 140, 45-61.
[http://dx.doi.org/10.1016/j.jpba.2017.03.016] [PMID: 28342304]
[56]
Shen, Y.; Zhang, Q.; Wu, Y.B.; He, Y.Q.; Han, T.; Zhang, J.H.; Zhao, L.; Hsu, H.Y.; Song, H.T.; Lin, B.; Xin, H.L.; Qi, Y.P.; Zhang, Q.Y. Pharmacokinetics and tissue distribution of monotropein and deacetyl asperulosidic acid after oral administration of extracts from Morinda officinalis root in rats. BMC Complement. Altern. Med., 2018, 18(1), 288-300.
[http://dx.doi.org/10.1186/s12906-018-2351-1] [PMID: 30355303]
[57]
Yang, Y.F.; Zhang, Y.B.; Chen, Z.J.; Zhang, Y.T.; Yang, X.W. Plasma pharmacokinetics and cerebral nuclei distribution of major constituents of Psoraleae fructus in rats after oral administration. Phytomedicine, 2018, 38, 166-174.
[http://dx.doi.org/10.1016/j.phymed.2017.12.002] [PMID: 29425649]
[58]
Yang, L.; Jiang, H.; Yan, M.; Xing, X.; Guo, X.; Man, W.; Hou, A.; Yang, B.; Wang, Q.; Kuang, H. Comparison of pharmacokinetics of phytoecdysones and triterpenoid saponins of monomer, crude and processed Radix Achyranthis Bidentatae by UHPLC-MS/MS. Xenobiotica, 2019, 50(6), 677-684.
[PMID: 30729838]
[59]
Wen, Y.Q.; Gong, L.Y.; Wang, L.; Zhao, N.; Sun, Q.; Kamara, M.O.; Ma, H.Y.; Meng, F.H. Comparative pharmacokinetics study of leonurine and stachydrine in normal rats and rats with cold-stagnation and blood-stasis primary dysmenorrhoea after the administration of Leonurus japonicus houtt electuary. J. Sep. Sci., 2019, 42(9), 1725-1732.
[http://dx.doi.org/10.1002/jssc.201801257] [PMID: 30839168]
[60]
Deng, G.; Liu, W.; Ma, C.; Rong, X.; Zhang, Y.; Wang, Y.; Wu, C.; Cao, N.; Ding, W.; Guan, H.; Cheng, X.; Wang, C. In vivo and in vitro metabolism and pharmacokinetics of cholinesterase inhibitor deoxyvasicine from aerial parts of Peganum harmala Linn in rats via UPLC-ESI-QTOF-MS and UPLC-ESI-MS/MS. J. Ethnopharmacol., 2019, 236, 288-301.
[http://dx.doi.org/10.1016/j.jep.2019.03.020] [PMID: 30872168]
[61]
Xu, W.; Li, X.; Lin, N.; Zhang, X.; Huang, X.; Wu, T.; Tai, Y.; Chen, S.; Wu, C.H.; Huang, M.; Wu, S. Pharmacokinetics and tissue distribution of five major triterpenoids after oral administration of Rhizoma Alismatis extract to rats using ultra high-performance liquid chromatography-tandem mass spectrometry. J. Pharm. Biomed. Anal., 2017, 146, 314-323.
[http://dx.doi.org/10.1016/j.jpba.2017.09.009] [PMID: 28910706]
[62]
Wu, J.; Wu, B.; Tang, C.; Zhao, J. Analytical techniques and pharmacokinetics of Gastrodia elata Blume and its constituents. Molecules, 2017, 22(7), 1137-1155.
[http://dx.doi.org/10.3390/molecules22071137] [PMID: 28698450]
[63]
Z. Gong Z.P. Chen Y. R.J.. Yang, Q., Zhu, X.X., Research progress on pharmacokinetics of traditional Chinese medicine in disease state. Zhongguo Zhongyao Zazhi, 2015, 40(2), 169-173.
[PMID: 26080539]
[64]
Zhang, J.; Fu, Y.; Li, L.; Liu, Y.; Zhang, C.; Yu, D.; Ma, Y.; Xiao, Y. Pharmacokinetic comparisons of major bioactive components after oral administration of raw and steamed rhubarb by UPLC-MS/MS. J. Pharm. Biomed. Anal., 2019, 171, 43-51.
[http://dx.doi.org/10.1016/j.jpba.2019.04.002] [PMID: 30965220]
[65]
Tao, Y.; Huang, S.; Yan, J.; Cai, B. Establishment of a rapid and sensitive UPLC-MS/MS method for pharmacokinetic determination of nine alkaloids of crude and processed Corydalis turtschaninovii Besser aqueous extracts in rat plasma. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2019, 1124, 218-225.
[http://dx.doi.org/10.1016/j.jchromb.2019.06.018] [PMID: 31233942]
[66]
Shan, J.J.; Zou, J.S.; Xie, T.; Kang, A.; Zhou, W.; Xu, J.Y.; Shen, C.S.; Du, L.N.; Wang, S.C.; Di, L.Q. Effects of Gancao on pharmacokinetic profiles of platycodin D and deapio-platycodin D in Jiegeng. J. Ethnopharmacol., 2015, 170, 50-56.
[http://dx.doi.org/10.1016/j.jep.2015.04.056] [PMID: 25980422]
[67]
Li, Y.; Guo, S.; Ren, Q.; Wei, D.; Zhao, M.; Su, S.; Tang, Z.; Duan, J.A. Pharmacokinetic comparisons of multiple triterpenic acids from Jujubae fructus extract following oral delivery in normal and acute liver injury rats. Int. J. Mol. Sci., 2018, 19(7)E2047
[http://dx.doi.org/10.3390/ijms19072047] [PMID: 30011885]
[68]
Li, Y.; Li, Y.X.; Dang, J.; Luo, L.; Yuan, A.; Zhao, M.J.; Gong, X.H.; Peng, C. Simultaneous determination and comparative pharmacokinetics of fuzi water-soluble alkaloids between normal and acute heart failure rats by ultra performance liquid chromatography method. J. Chromatogr. Sci., 2017, 55(7), 719-728.
[http://dx.doi.org/10.1093/chromsci/bmx026] [PMID: 28369274]
[69]
Zhuang, Y.; Qin, K.; Liu, X.; Cai, B.; Cai, H. Ultra-high-performance liquid chromatography with tandem mass spectrometry method for determination of four compounds in rat plasma after oral administration of Xanthii fructus and stir-fried Xanthii fructus extracts. Biomed. Chromatogr., 2019, 33(4)e4464
[PMID: 30536751]
[70]
Xie, L.; Liu, X.; Zhu, X.; Xu, Y.; Peng, S.; Sun, K.; Cai, H.; Dai, Q.; Wang, C.; Zhou, Q.; Cai, B. Development of an UHPLC-MS/MS method for comparative pharmacokinetics of nine anthraquinones in rats and application to dosage conversion between different Semen Cassiae forms. J. Pharm. Biomed. Anal., 2019, 174, 696-706.
[http://dx.doi.org/10.1016/j.jpba.2019.07.001] [PMID: 31288192]
[71]
Yang, B.; Xie, L.; Peng, S.; Sun, K.; Jin, J.; Zhen, Y.; Qin, K.; Cai, B. Nine components pharmacokinetic study of rat plasma after oral administration raw and prepared Semen Cassiae in normal and acute liver injury rats. J. Sep. Sci., 2019, 42(14), 2341-2350.
[http://dx.doi.org/10.1002/jssc.201900007] [PMID: 31037812]
[72]
Tao, Y.; Yan, J.; Cai, B. A liquid chromatography-tandem mass spectrometry approach for study the tissue distributions of five components of crude and salt-processed Radix Achyranthes in rats. Biomed. Chromatogr., 2019, 33(6)e4483
[http://dx.doi.org/10.1002/bmc.4483] [PMID: 30632626]
[73]
Cui, Y.; Liu, T.; Zhang, Y.; Wang, R.; Liu, X.; Zhang, Q.; Yu, P.; Zhao, Y.; Yu, Z. Simultaneous determination of five bioactive components of Gancao in rat plasma by UHPLC-MS/MS and its application to comparative pharmacokinetic study of incompatible herb pair Gansui-Gancao and Gansuibanxia Decoction. J. Pharm. Biomed. Anal., 2018, 159, 318-325.
[http://dx.doi.org/10.1016/j.jpba.2018.07.014] [PMID: 30015102]
[74]
Zeng, H.; Xue, P.; Su, S.; Huang, X.; Shang, E.; Guo, J.; Qian, D.; Tang, Y.; Duan, J.A. Comparative pharmacokinetics of three major bioactive components in rats after oral administration of Typhae Pollen-Trogopterus Feces drug pair before and after compatibility. Daru, 2016, 24, 2.
[http://dx.doi.org/10.1186/s40199-016-0140-2] [PMID: 26792373]
[75]
Xia, Z.; Lv, L.; Di, X.; Xue, J.; Gao, Z.; Zhang, G.; Zhang, H. The compatibility of six alkaloids in ermiao pill explored by a comparative pharmacokinetic and network pharmacological study. Biomed. Chromatogr., 2019, 33(5)e4509
[http://dx.doi.org/10.1002/bmc.4509] [PMID: 30756408]
[76]
Liu, Y.; Chi, S.; Wang, W.; Su, L.; Liu, B. Simultaneous determination of seven components in rat plasma by the UPLC-MS/MS method and application of pharmacokinetic studies to SimiaoYong’an Decoction. Molecules, 2017, 22(11), 1-16.
[http://dx.doi.org/10.3390/molecules22111937] [PMID: 29120359]
[77]
Bo, Y.; Wang, L.; Wu, X.; Zhao, L.; Yang, J.; Xiong, Z.; Wu, C. Development and validation of a UHPLC-MS/MS method for the simultaneous determination of five bioactive flavonoids in rat plasma and comparative pharmacokinetic study after oral administration of Xiaochaihu Tang and three compatibilities. J. Sep. Sci., 2017, 40(9), 1896-1905.
[http://dx.doi.org/10.1002/jssc.201601420] [PMID: 28306207]
[78]
Sun, L.; Ding, F.; You, G.; Liu, H.; Wang, M.; Ren, X.; Deng, Y. Development and validation of an UPLC-MS/MS Method for pharmacokinetic comparison of five alkaloids from JinQi Jiangtang tablets and its monarch drug Coptidis Rhizoma. Pharmaceutics, 2017, 10(1)E4
[http://dx.doi.org/10.3390/pharmaceutics10010004] [PMID: 29286316]
[79]
Shen, X.; Li, L.; Ma, Q.; Chen, H.; Wang, J.; Lv, L.; Li, Y. Pharmacokinetic study of eight bioactive components following oral administration of Zhiqiao Gancao decoction and observation of its clinical efficacy. Biomed. Chromatogr., 2020, 34(2)e4706
[http://dx.doi.org/10.1002/bmc.4706] [PMID: 31629372]
[80]
Li, Z.; Wen, R.; Du, Y.; Zhao, S.; Zhao, P.; Jiang, H.; Rong, R.; Lv, Q. Simultaneous quantification of fifteen compounds in rat plasma by LC-MS/MS and its application to a pharmacokinetic study of Chaihu-Guizhi decoction. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2019, 1105, 15-25.
[http://dx.doi.org/10.1016/j.jchromb.2018.12.006] [PMID: 30554094]
[81]
Zhu, H.; Liu, X.; Zhu, T.T.; Wang, X.L.; Qin, K.M.; Pei, K.; Cai, B.C. UHPLC-MS/MS method for the simultaneous quantitation of five anthraquinones and gallic acid in rat plasma after oral administration of prepared rhubarb decoction and its application to a pharmacokinetic study in normal and acute blood stasis rats. J. Sep. Sci., 2017, 40(11), 2382-2389.
[http://dx.doi.org/10.1002/jssc.201700166] [PMID: 28426176]
[82]
Liu, H.; Qiu, F.; Yang, X.; Zhao, H.; Bian, B.; Wang, L. Pharmacokinetics of the Yougui pill in experimental autoimmune encephalomyelitis model rats and its pharmacological activity in vitro. Drug Des. Devel. Ther., 2019, 13, 2357-2370.
[http://dx.doi.org/10.2147/DDDT.S203874] [PMID: 31409970]
[83]
Zuo, L.; Zhong, Q.; Wang, Z.; Sun, Z.; Zhou, L.; Li, Z.; Xu, T.; Shi, Y.; Tang, J.; Du, S.; Zhang, X. Simultaneous determination and pharmacokinetic study of twelve bioactive compounds in rat plasma after intravenous administration of Xuebijing injection by UHPLC-Q-Orbitrap HRMS. J. Pharm. Biomed. Anal., 2017, 146, 347-353.
[http://dx.doi.org/10.1016/j.jpba.2017.09.010] [PMID: 28918324]
[84]
Shen, J.; Wei, J.; Li, L.; Ouyang, H.; Chang, Y.; Chen, X.; He, J. Development of a HPLC-MS/MS method to determine 11 bioactive compounds in Tongmai Yangxin pill and application to a pharmacokinetic study in rats. Evid. Based Complement. Alternat. Med., 2018, 2018(3), 1-11.
[85]
Pang, H.Q.; Tang, Y.P.; Cao, Y.J.; Tan, Y.J.; Jin, Y.; Shi, X.Q.; Huang, S.L.; Sun, D.Z.; Sun, J.; Tang, Z.S.; Duan, J.A. Comparatively evaluating the pharmacokinetic of fifteen constituents in normal and blood deficiency rats after oral administration of Xin-Sheng-Hua granule by UPLC-MS/MS. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2017, 1061-1062, 372-381.
[http://dx.doi.org/10.1016/j.jchromb.2017.07.042] [PMID: 28802217]
[86]
Qian, P.; Zhang, Y.B.; Yang, Y.F.; Xu, W.; Yang, X.W. Pharmacokinetics studies of 12 alkaloids in rat plasma after oral administration of Zuojin and Fan-Zuojin formulas. Molecules, 2017, 22(2)E214
[http://dx.doi.org/10.3390/molecules22020214] [PMID: 28146096]

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