Login Register Cart 0
Generic placeholder image

Current Drug Metabolism

Editor-in-Chief

ISSN (Print): 1389-2002
ISSN (Online): 1875-5453

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

Study on the Plasma Protein Binding Rate and Compatibility Regularity of the Constituents Migrating to Blood of Simiao Yong’an Decoction

Author(s): Xiao Yu, Qishu Jiao, Yanyan Jiang, Shuzhen Guo, Wei Zhang* and Bin Liu*

Volume 21, Issue 12, 2020

Page: [979 - 993] Pages: 15

DOI: 10.2174/1567201817666200731170731

Price: $65

Abstract

Objective: To study the compatibility regularity of Simiao Yong’an decoction by determining the plasma protein binding rate with the constituents in Simiao Yong’an decoction and to preliminarily clarify the effects of the compatibility on the plasma protein binding rate of different components.

Methods: Based on the equilibrium dialysis method, high-performance liquid chromatography was used to determine the contents of six constituents, which were divided into a single group and combination groups, in Simiao Yong’an decoction in the internal and external dialysis solutions. The obtained plasma protein binding rate through calculations was an index to evaluate the binding of the above components to plasma protein in different conditions.

Results: Harpagide, harpagoside, sweroside and loganin showed low plasma protein binding rates, ferulic acid exhibited a moderate plasma protein binding rate, and glycyrrhizic acid showed a high plasma protein binding rate. The compatibility study showed that glycyrrhizic acid promoted the binding of ferulic acid to plasma protein. Glycyrrhizic acid and ferulic acid were the key compounds to promote the binding of harpagide to plasma protein. Glycyrrhizic acid, harpagide, harpagoside and loganin had a significant inhibitory effects on the binding of sweroside to plasma protein. The plasma protein binding capacities of harpagoside and loganin were reduced by the other five constituents. Glycyrrhizic acid had the strongest plasma protein binding effect, and the binding effect was not affected by other components.

Conclusion: This study explores the effects of compound compatibility on effective components from the perspective of plasma protein binding by high-performance liquid chromatography combined with the equilibrium dialysis method, and lays a foundation for clarifying the compatibility rule of Simiao Yong’an decoction and also provides a new idea for the study of the compatibility of traditional Chinese medicine formulas.

Keywords: Plasma protein binding rate, equilibrium dialysis, pharmacokinetics, traditional Chinese medicine compound, drug interaction, Simiao Yong’an decoction.

« Previous
Graphical Abstract

[1]
Banker, M.J.; Clark, T.H. Plasma/serum protein binding determinations. Curr. Drug Metab., 2008, 9(9), 854-859.
[http://dx.doi.org/10.2174/138920008786485065] [PMID: 18991581]
[2]
Jiao, Q.; Wang, R.; Jiang, Y.; Liu, B. Study on the interaction between active components from traditional Chinese medicine and plasma proteins. Chem. Cent. J., 2018, 12(1), 48.
[http://dx.doi.org/10.1186/s13065-018-0417-2] [PMID: 29728878]
[3]
Bi, X.L.; Gong, M.R.; Di, L.Q. Review on prescription compatibility of Shaoyao Gancao Decoction and reflection on pharmacokinetic compatibility mechanism of traditional Chinese medicine prescription based on in vivo drug interaction of main efficacious components; Evid-based Compl. Alt. Med., 2014, 2014208129
[4]
Ma, Y.; Fan, R.; Duan, M.; Yu, Z.; Zhao, Y. A study of pharmacokinetic interactions among co-existing ingredients in Viscum coloratum after intravenous administration of three different preparations to rats. Pharmacogn. Mag., 2015, 11(43), 455-462.
[http://dx.doi.org/10.4103/0973-1296.160448] [PMID: 26246719]
[5]
Su, X.F.; Yao, Z.T.; Li, S.T.; Sun, H. Synergism of Chinese herbal medicine: illustrated by Danshen Compound; Evid-based Compl. Alt. Med., 2016, 20167279361
[6]
Wang, X.; He, C.; Chen, Y.; Chen, J.; Cai, B. Determination and comparison of plasma protein binding rate of alkaloids from seed of Strychnou nux-vomica. Zhongguo Zhongyao Zazhi, 2011, 36(2), 185-188.
[PMID: 21506420]
[7]
Xiong, X.; Yang, X.; Liu, Y.; Zhang, Y.; Wang, P.; Wang, J. Chinese herbal formulas for treating hypertension in traditional Chinese medicine: perspective of modern science. Hypertens. Res., 2013, 36(7), 570-579.
[http://dx.doi.org/10.1038/hr.2013.18] [PMID: 23552514]
[8]
Wang, X.; Fang, G.; Pang, Y. Chinese medicines in the treatment of prostate cancer: from formulas to extracts and compounds. Nutrients, 2018, 10(3), 283.
[http://dx.doi.org/10.3390/nu10030283] [PMID: 29495626]
[9]
Wang, L.; Zhou, G.B.; Liu, P.; Song, J.H.; Liang, Y.; Yan, X.J.; Xu, F.; Wang, B.S.; Mao, J.H.; Shen, Z.X.; Chen, S.J.; Chen, Z. Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia. Proc. Natl. Acad. Sci. USA, 2008, 105(12), 4826-4831.
[http://dx.doi.org/10.1073/pnas.0712365105] [PMID: 18344322]
[10]
Wang, M.Z.; Shi, Y.; Yang, Z.X. Advances in research of traditional Chinese medicine compound Yitangkang in the treatment of type 2 diabetes. Liaoning Zhongyiyao Daxue Xuebao, 2019, 21(10), 217-221.
[11]
Zang, C.X.; Bao, X.Q.; Sun, H.; Zhang, D. Advances in the treatment of Alzheimer’s disease by traditional chinese medicine compounds. Pharmacol. Clin. Chin. Mater. Clin. Med., 2016, 32(4), 157-161.
[12]
Xi, J.Y.; Zhu, Y.Q.; Zhu, Y.P.; Huang, L.M.; Wei, W.; Lin, S.N.; Tang, Y.M.; Luo, Z.Q. Clinical research progress of Compound Chinese Medicine in dialectical treatment of chronic atrophic gastritis. Lishizhen Med. Mater. Med. Res., 2016, 27(12), 2978-2980.
[13]
Xu, C.H.; Wang, P.; Wang, Y.; Yang, Y.; Li, D.H.; Li, H.F.; Sun, S.Q.; Wu, X.Z. Pharmacokinetic comparisons of two different combinations of Shaoyao-Gancao Decoction in rats: competing mechanisms between paeoniflorin and glycyrrhetinic acid. J. Ethnopharmacol., 2013, 149(2), 443-452.
[http://dx.doi.org/10.1016/j.jep.2013.06.049] [PMID: 23867078]
[14]
Chen, Y.H.; Tang, S.Y.; Liu, X.L.; Zhang, X.D.; Wan, P.; Huang, W.; Tang, S.Q. Effect of Radix Platycodonis and Radix Cyathulae in Xuefu Zhuyu Tang on tissue distribution of paeoniflorin in blood-stasis mice by HPLC: experimental evidence on Shi ingredients in traditional formula compatibility. Indian J. Tradit. Knowl., 2019, 18(3), 516-524.
[15]
Yang, Y.F.; Zhou, Q.L.; Yang, X.W. Elucidation of compatibility interactions of traditional Chinese medicines: in vitro absorptions across Caco-2 monolayer of Coptidis Rhizoma and Euodiae Fructus in Zuojin and Fanzuojin Formulas as a case. Phytother. Res., 2017, 31(8), 1220-1229.
[http://dx.doi.org/10.1002/ptr.5843] [PMID: 28557048]
[16]
Wang, S.; Hu, Y.; Tan, W.; Wu, X.; Chen, R.; Cao, J.; Chen, M.; Wang, Y. Compatibility art of traditional Chinese medicine: from the perspective of herb pairs. J. Ethnopharmacol., 2012, 143(2), 412-423.
[http://dx.doi.org/10.1016/j.jep.2012.07.033] [PMID: 22871585]
[17]
Sun, Y.; Feng, G.; Zheng, Y.; Liu, S.; Zhang, Y.; Pi, Z.; Song, F.; Liu, Z. Putative multiple reaction monitoring strategy for the comparative pharmacokinetics of postoral administration Renshen-Yuanzhi compatibility through liquid chromatography-tandem mass spectrometry. J. Ginseng Res., 2020, 44(1), 105-114.
[http://dx.doi.org/10.1016/j.jgr.2018.09.007] [PMID: 32148393]
[18]
Hu, Q.; Li, X.; Shi, Q.; Yang, G.; Feng, F. Deciphering the absorption profile and interaction of multi-components of Zhi-Zi-Da-Huang decoction based on in vitro-in silico-in vivo integrated strategy. Xenobiotica, 2019, 49(7), 762-777.
[http://dx.doi.org/10.1080/00498254.2018.1497220] [PMID: 30207187]
[19]
Wu, L.H.; Hou, J.; Wang, J.; Luo, M.; Wang, L.M.; Wang, J.X.; Li, Y.J.; Qin, J. Effect of combination of gastrodia and uncaria on pharmacokinetics of gastrodin and rhynchophylline. Zhongguo Zhongyao Zazhi, 2017, 42(13), 2577-2582.
[PMID: 28840702]
[20]
Tang, Z.; Yin, R.; Bi, K.; Zhu, H.; Han, F.; Chen, K.; Wang, F. Simultaneous quantitative determination of 20 active components in the traditional Chinese medicine formula Zhi-Zi-Da-Huang decoction by liquid chromatography coupled with mass spectrometry: application to study the chemical composition variations in different combinations. Biomed. Chromatogr., 2015, 29(9), 1406-1414.
[http://dx.doi.org/10.1002/bmc.3438] [PMID: 25678253]
[21]
Wang, Q.; Song, W.; Qiao, X.; Ji, S.; Kuang, Y.; Zhang, Z.X.; Bo, T.; Guo, D.A.; Ye, M. Simultaneous quantification of 50 bioactive compounds of the traditional Chinese medicine formula Gegen-Qinlian decoction using ultra-high performance liquid chromatography coupled with tandem mass spectrometry. J. Chromatogr. A, 2016, 1454, 15-25.
[http://dx.doi.org/10.1016/j.chroma.2016.05.056] [PMID: 27262372]
[22]
Liu, H.; Su, J.; Yang, X.; He, Y.J.; Li, H.Y.; Ye, J.; Zhang, W.D. A novel approach to characterize chemical consistency of traditional Chinese medicine Fuzi Lizhong Pills by GC-MS and RRLC-Q-TOF MS. Chin. J. Nat. Med., 2011, 9(4), 267-273.
[http://dx.doi.org/10.1016/S1875-5364(11)60063-0]
[23]
Wang, H.; Sun, H.; Zhang, A.; Li, Y.; Wang, L.; Shi, H.; Dizou, X.L.; Wang, X. Rapid identification and comparative analysis of the chemical constituents and metabolites of Phellodendri amurensis cortex and Zhibai dihuang pill by ultra-performance liquid chromatography with quadrupole TOF-MS. J. Sep. Sci., 2013, 36(24), 3874-3882.
[http://dx.doi.org/10.1002/jssc.201300794] [PMID: 24151052]
[24]
Fan, H.; Liu, S.; Shen, W.; Kang, A.; Tan, J.; Li, L.; Liu, X.; Xu, C.; Xu, X.; Lai, Y.; Cheng, H.; Sun, D. Identification of the absorbed components and metabolites of Xiao-Ai-Jie-Du decoction and their distribution in rats using ultra high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry. J. Pharm. Biomed. Anal., 2020, 179112984
[http://dx.doi.org/10.1016/j.jpba.2019.112984] [PMID: 31759764]
[25]
Sun, Y.G.; Du, Y.F.; Yang, K.; Chang, L.; Cao, L.; Ren, Y.P.; Sun, Q.; Wang, Q.; Zhang, L.T.; Lv, P.T. A comparative study on the pharmacokinetics of a traditional Chinese herbal preparation with the single herb extracts in rats by LC-MS/MS method. J. Pharm. Biomed. Anal., 2013, 81-82, 34-43.
[http://dx.doi.org/10.1016/j.jpba.2013.03.022] [PMID: 23624157]
[26]
Zhou, M.; Hong, Y.; Lin, X.; Shen, L.; Feng, Y. Recent pharmaceutical evidence on the compatibility rationality of traditional Chinese medicine. J. Ethnopharmacol., 2017, 206, 363-375.
[http://dx.doi.org/10.1016/j.jep.2017.06.007] [PMID: 28606807]
[27]
Sun, J.H.; Zhao, H.F.; Guo, X.L.; Zou, L.; Liu, G.F. Research progress on plasma protein binding rates of active ingredients of traditional Chinese medicine and discussion on related regularities. Pract. Pharm. Clin. Remed., 2017, 20(1), 91-97.
[28]
Liu, P.; Wang, P.; Liu, S.L.; Chen, G.; Han, L.T. Consideration on rules of compound prescriptions of Chinese medicine from point of herb-pair. Chin. Arch. Tradit. Chi. Med., 2010, 28(9), 1833-1835.
[29]
Chen, H.J.; Chen, Z.J.; Du, G.L. Modern research progress on compatibility rules of traditional Chinese medicine prescription. Chin. Arch. Tradit. Chi. Med., 2018, 36(12), 2835-2841.
[30]
Zhou, Y.; Su, S.B. Research methods of compatibility of traditional Chinese medicine formulas and its advances. Tradit. Med. Form., 2019, 25(23), 202-208.
[31]
Xin, C.X.; Liang, J.; Zhou, Y.S.; Yang, C.C.; Xu, H. Research situation in compatibility mechanism of traditional Chinese medicine compound preparations. Zhongguo Xin Yao Zazhi, 2018, 27(24), 2895-2900.
[32]
Liu, S.; Zhang, X.F.; Miao, X.; Xing, H.Y.; Li, G. Study on compatibility proportion of Mongolian medicine “Terminalia chebula decomposing poison of Aconitum kusnezoffii”. Chin. Pharm., 2019, 30(11), 1519-1524.
[33]
Zhang, Q.; Dai, G.L.; Ju, W.Z.; Guo, J.M.; Sun, B.T.; Zong, Y.; He, S.F.; Duan, J.A. Determination of binding rates of human plasma protein with seven bioactive components in Danhong injection. Chin. Pharmacol. Bull., 2017, 33(5), 712-718.
[34]
Shen, L.; Cong, W.J.; Lin, X.; Hong, Y.L.; Hu, R.W.; Feng, Y.; Xu, D.S.; Ruan, K.F. Characterization using LC/MS of the absorption compounds and metabolites in rat plasma after oral administration of a single or mixed decoction of Shaoyao and Gancao. Chem. Pharm. Bull. (Tokyo), 2012, 60(6), 712-721.
[http://dx.doi.org/10.1248/cpb.60.712] [PMID: 22689421]
[35]
Han, L.; Wang, R.; Wu, B.; Gu, Y.Q.; Yuan, Y.F. Effect of diammonium glycyrrhizinate on the pharmacokinetics of omeprazole by regulating CYP450 enzyme and the binding rate of plasma protein. Zhongguo Yaolixue Yu Dulixue Zazhi, 2019, 33(10), 819-820.
[36]
Hu, X.B.; Liu, Y.M.; Wu, R.J.; Hu, X.; Yan, Y.Q.; Ling, X.M. A novel, fast method to determine free and total drug concentrations and plasma protein-binding rate of disopyramide in rat plasma by capillary dectrophoresis. J. Pharm. Anal., 2018, 38(7), 1174-1182.
[37]
Li, R.G.; Chen, L.J.; Jiang, T.M.; Xu, C. Studies on the interactions between proteins and drug small molecules by equilibrium dialysis Biotech. Bullet, 2010, 80-84.
[38]
Chen, H.H.; Wang, X.M.; Pan, G.X.; Li, T.T. Detection of the human plasma protein binding rate of periplocin, periplocymarin and periplogenin. Liaoning Zhongyiyao Daxue Xuebao, 2017, 19(7), 32-35.
[39]
Zhang, H.; Wang, P.; Zhang, Y.; Liu, H.; Miao, S.Y.; Meng, X.L. Study on plasma protein binding rate of rhubarb free anthraquinones by equilibrium dialysis method in rats plasma. Pharmacol. Clin. Chin. Mater. Clin. Med., 2012, 28(2), 34-36.
[40]
Chemlal, L.; Akachar, J.; Makram, S.; Zoubir, B.; Cherrah, Y.; Eljaoudi, R.; Ibrahimi, A.; Faouzi, M.A. The displacement study of 99m Tc-DTPA-Human serum albumin binding in presence of furosemide and metformin by using equilibrium dialysis and molecular docking. IUBMB Life, 2019, 71(12), 2003-2009.
[http://dx.doi.org/10.1002/iub.2167] [PMID: 31633875]
[41]
Bao, H.S.; Hou, J.Y.; Hu, H.J.; Li, Y.T.; Zheng, L.; Huang, Y.; Wang, G.C.; Zhou, M.; Lan, Y.Y.; Gong, Z.P. [Determination of plasma protein binding rates of nine compounds of Inula cappa extraction based on method of equilibrium dialysis] Zhongguo Zhongyao Zazhi, 2019, 44(7), 1475-1484.
[PMID: 31090307]
[42]
Zheng, L.; Wang, M.Y.; Chen, Z.; Li, X.B. Research progress of Simiao Yong’an Detection. Chi. Tradit. Patent Med., 2019, 41(6), 1365-1370.
[43]
Zhang, K.X.; Liu, S.M. Research progress of Simiao Yong’an Decoction. Chin. Bull. Drug Depend., 2019, 28(6), 415-419.
[44]
Li, N.; Qu, X.B.; Lin, S.; Li, H.; Lin, H.; Li, J.; Lv, G.F.; Wu, X.Y.; Lin, Z. Protect effect of Simiao Yong’an Decoction on thromboangitis obliterans in rats. Chin. J. Exp. Tradit. Med. Form., 2013, 19(8), 225-227.
[45]
Zhao, Y.; Jiang, Y.; Chen, Y.; Zhang, F.; Zhang, X.; Zhu, L.; Yao, X. Dissection of mechanisms of Chinese medicinal formula Si-Miao-Yong-an decoction protects against cardiac hypertrophy and fibrosis in isoprenaline-induced heart failure. J. Ethnopharmacol., 2020, 248112050
[http://dx.doi.org/10.1016/j.jep.2019.112050] [PMID: 31265887]
[46]
Chi, S.S.; Wang, W.H.; Liu, B. Absorbed constituents in rat serum after oral administration of water extract of Simiao Yong’an Decoction. J. Beijing Univ. Chin. Med., 2016, 39(11), 933-940.
[47]
Ji, X.Y.; Wang, C.; Liu, B. Decomposition analysis on sweroside and loganin extraction rate changes in Simiao Yongan Tang. Chin. J. Exp. Med. Formul., 2014, 20(17), 102-105.
[48]
Diao, Y.L.; Wang, C.; Zhang, L.; Wang, Y.X.; Liu, B. Influence of disassembled Simiao Yong’an Tang on extraction rate of glycyrrhizic acid. J. Beijing Univ. Chin. Med., 2013, 36(11), 771-774.
[49]
Zhang, E.H.; Wang, C.; Liu, B. Separated Recipes Analysis on extraction rate of harpagide in Simiao Yong’an Decoction. Chin. J. Exp. Med. Formul., 2013, 19(13), 45-47.
[50]
Yu, X.; Chi, S.S.; Jiao, Q.S.; Jiang, L.J.; Wang, W.H.; Jiang, Y.Y.; Liu, B. [Study on compatibility of active ingredients of Simiao Yongan Decoction in rats with in situ single-pass intestinal perfusion model] Zhongguo Zhongyao Zazhi, 2019, 44(10), 2163-2170.
[PMID: 31355576]
[51]
Yu, X.; Chi, S.S.; Jiao, Q.S.; Jiang, L.J.; Wang, W.H.; Jiang, Y.Y.; Liu, B. Intestinal absorption of iridoid glycosides in Simiao Yong’an Tang with different compatibility. J. Beijing Univ. Chin. Med., 2019, 42(7), 592-601.
[52]
Zhang, Q.H.; Gong, C.; Yang, H.; Wei, H.; Zhou, W.B.; Qi, C.; Wang, C.H. Pharmacokinetics of cisplatin in the absence or presence of zengmian yiliu granules (a traditional Chinese medicine compound) in rats determined via ICP-MS: an investigation on drug-herb interactions. Pharm. Biol., 2015, 53(2), 159-166.
[http://dx.doi.org/10.3109/13880209.2014.912241] [PMID: 25339463]
[53]
Ji, S.; He, D.D.; Su, Z.Y.; Du, Y.; Wang, Y.J.; Gao, S.K.; Guo, M.Z.; Tang, D.Q. P450 enzymes-based metabolic interactions between monarch drugs and the other constituent herbs: a strategy to explore compatibility mechanism of Sangju-Yin. Phytomedicine, 2019, 58152866
[http://dx.doi.org/10.1016/j.phymed.2019.152866] [PMID: 30831464]
[54]
Cui, X.; Shen, Y.M.; Jiang, S.; Qian, D.W.; Shang, E.X.; Zhu, Z.H.; Duan, J.A. Comparative analysis of the main active components and hypoglycemic effects after the compatibility of Scutellariae Radix and Coptidis Rhizoma. J. Sep. Sci., 2019, 42(8), 1520-1527.
[http://dx.doi.org/10.1002/jssc.201801204] [PMID: 30734512]
[55]
Li, X.W.; Zhang, H.Y.; Zhu, J.X. Advances in pharmacokinetics of traditional Chinese medicine compounds. J. Tradit. Chin. Med., 2015, 14(5), 65-69.
[56]
Xu, F.; Wu, Q.N.; Chen, J.; Gu, W.; Fang, F.; Zhang, L.Q.; Zhao, B. The binding mechanisms of plasma protein to active compounds in Alismaorientale rhizomes (Alismatis Rhizoma). Bioorg. Med. Chem. Lett., 2014, 24(17), 4099-4105.
[http://dx.doi.org/10.1016/j.bmcl.2014.07.065] [PMID: 25106886]
[57]
Jia, Y.W.; Shen, J.; Xie, H.T.; Li, X.H.; Liang, D.H.; Wang, M.H.; Hu, H. Analysis of plasma protein binding of helicid using equilibrium dialysis method: an investigation on species differences. Nat. Prod. Res. Dev., 2016, 28(1), 30-36.
[58]
Tang, D.Q.; Li, Y.J.; Li, Z.; Bian, T.T.; Chen, K.; Zheng, X.X.; Yu, Y.Y.; Jiang, S.S. Study on the interaction of plasma protein binding rate between edaravone and taurine in human plasma based on HPLC analysis coupled with ultrafiltration technique. Biomed. Chromatogr., 2015, 29(8), 1137-1145.
[http://dx.doi.org/10.1002/bmc.3401] [PMID: 25545282]
[59]
Zeng, H.P.; Chen, H.; Chen, D.; Ma, G.P.; Zhu, X.M.; Hong, L.T.; Liu, X.M.; Ke, Y.F. [Binding characteristics of plasma protein in active parts of Daidai lipid-lowering flavonoid extract] Zhongguo Zhongyao Zazhi, 2019, 44(9), 1911-1920.
[PMID: 31342721]
[60]
Cheng, J.W.; Dong, W.B.; Chen, A.Y.; Cheng, M.; Wang, J.Q.; Zheng, G.L. Comparison of microdialysis and ultrafiltration methods for determination of plasma protein binding rate of polydatin in vitro. Chin. J. Mod. Appl. Pharma., 2013, 30(11), 1174-1178.
[61]
Miao, P.P.; Zhao, Y.Y.; Miao, Q.; Guo, C.E.; Chen, H.Y.; Chen, N.; Zhang, Y.J.; Ma, S.C. Comparison of the interactions of epiberberine and berberine with bovine serum albumin. Zhongguo Xin Yao Zazhi, 2016, 25(6), 705-711.
[62]
Singh, D.V.; Bharti, S.K.; Agarwal, S.; Roy, R.; Misra, K. Study of interaction of human serum albumin with curcumin by NMR and docking. J. Mol. Model., 2014, 20(8), 2365.
[http://dx.doi.org/10.1007/s00894-014-2365-7] [PMID: 25031079]
[63]
Liu, Y.Y.; Chi, S.S.; Wang, W.H.; Su, L.; Liu, B. Simultaneous determination of seven components in rat plasma by the UPLC-MS/MS method and application of pharmacokinetic studies to Simiao Yong’an Decoction. Molecules, 2017, 22(11), 1937.
[http://dx.doi.org/10.3390/molecules22111937]
[64]
Guan, J.; Ding, S.; Liu, Z.H.; Dong, X.X.; Yan, F.; Shi, S. Recent advances in determination methods of drug protein binding. Zhongguo Xin Yao Zazhi, 2014, 23(10), 1149-1153.
[65]
Chen, R.; Zhu, L.; Zhang, H.X. Comparative study of the different methods for determining the binding ratio between mangiferin and bovine serum albumin. J. Lanzhou Univ. Med. Sci., 2011, 37(1), 55-58.
[66]
Bao, H.W.; Hou, X.L.; Liu, F.X.; Liu, J.; Li, L.J. Determination of plasma protein binding rate of resveratrol by ultrafiltration and HPLC. Chin. J. Ethnomed. Ethnopharm., 2016, 25(20), 23-26.
[67]
Zhang, T.; Liu, X.X.; Chao, R.B. Determination of rat plasma protein binding rate of mesaconine by UPLC-MS/MS. Chung Kuo Yao Hsueh Tsa Chih, 2018, 53(5), 388-392.
[68]
Bao, H.W.; Xu, Y.; Liu, F.X. Plasma protein binding rate of ephedrine hydrochloride by ultrafiltration. J. Changchun Norm. Univ., 2018, 37(10), 78-81.
[69]
Yao, Y.; Zhang, X.; Wang, Z.; Zheng, C.; Li, P.; Huang, C.; Tao, W.; Xiao, W.; Wang, Y.; Huang, L.; Yang, L. Deciphering the combination principles of traditional Chinese medicine from a systems pharmacology perspective based on Ma-huang Decoction. J. Ethnopharmacol., 2013, 150(2), 619-638.
[http://dx.doi.org/10.1016/j.jep.2013.09.018] [PMID: 24064232]
[70]
Shi, L.; Tang, X.; Dang, X.; Wang, Q.; Wang, X.; He, P.; Wang, Q.; Liu, L.; Liu, X.; Zhang, Y. Investigating herb-herb interactions: the potential attenuated toxicity mechanism of the combined use of Glycyrrhizae radix et rhizoma (Gancao) and Sophorae flavescentis radix (Kushen). J. Ethnopharmacol., 2015, 165, 243-250.
[http://dx.doi.org/10.1016/j.jep.2015.02.022] [PMID: 25701755]
[71]
Zhou, B.; Zhang, J.; Wu, S.; Zhuo, Q.; Gao, W.; Hao, J.; Man, S. The influence of compatibility of processed radix Aconiti Kusnezoffii on the pharmacokinetic of four components in Glycyrrhiza uralensis Fisch. J. Ethnopharmacol., 2015, 169, 1-7.
[http://dx.doi.org/10.1016/j.jep.2015.03.059] [PMID: 25889555]
[72]
Wen, M.; Jiang, S.; Ju, A.X.; Li, Q.H. Compound compatibility law of Rhubarb and Aconite Decoction based on CYP450 enzymes. Chung Kuo Yao Hsueh Tsa Chih, 2019, 54(22), 1846-1852.
[73]
Zhang, C.Y.; Ren, W.G. Pharmacokinetic research strategies of compatibilities and synergistic effects of classical Danshen herb pairs based on pharmacokinetics of “Danshen-Bingpian” and “Danshen-Honghua”. Zhongguo Zhongyao Zazhi, 2017, 42(12), 2413-2419.
[74]
Zhou, J.; Cai, H.; Tu, S.; Duan, Y.; Pei, K.; Xu, Y.; Liu, J.; Niu, M.; Zhang, Y.; Shen, L.; Zhou, Q. Identification and analysis of compound profiles of Sinisan based on “individual herb, herb-pair, herbal formula” before and after processing using UHPLC-Q-TOF/MS coupled with multiple statistical strategy. Molecules, 2018, 23(12), 3128.
[http://dx.doi.org/10.3390/molecules23123128] [PMID: 30501046]
[75]
Liu, P.; Shang, E.X.; Zhu, Y.; Qian, D.W.; Duan, J.A. Volatile component interaction effects on compatibility of Cyperi Rhizoma and Angelicae Sinensis Radix or Chuanxiong Rhizoma by UPLC-MS/MS and response surface analysis. J. Pharm. Biomed. Anal., 2018, 160, 135-143.
[http://dx.doi.org/10.1016/j.jpba.2018.07.060] [PMID: 30086506]
[76]
Ji, S.; Liu, Z.Z.; Wu, J.; Du, Y.; Su, Z.Y.; Wang, T.Y.; Han, J.; Yang, D.Z.; Guo, M.Z.; Tang, D.Q. Chemical profiling and comparison of Sangju Ganmao tablet and its component herbs using two-dimensional liquid chromatography to explore compatibility mechanism of herbs. Front. Pharmacol., 2018, 9, 1167.
[http://dx.doi.org/10.3389/fphar.2018.01167] [PMID: 30386241]
[77]
Xu, T.; Pi, Z.; Liu, S.; Song, F.; Liu, Z. Chemical profiling combined with “Omics” technologies (CP-Omics): a strategy to understand the compatibility mechanisms and simplify herb formulas in traditional Chinese medicines. Phytochem. Anal., 2017, 28(5), 381-391.
[http://dx.doi.org/10.1002/pca.2685] [PMID: 28387961]
[78]
Li, M.; Chen, X.; Hu, S.; Wang, R.; Peng, X.; Bai, X. Determination of blood concentrations of main active compounds in Zi-Cao-Cheng-Qi decoction and their total plasma protein binding rates based on hollow fiber liquid phase microextraction coupled with high performance liquid chromatography. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2018, 1072, 355-361.
[http://dx.doi.org/10.1016/j.jchromb.2017.11.046] [PMID: 29223049]
[79]
Li, H.Y.; He, P.; He, Y.T.; Fan, Q.M.; Xiao, M.F.; Liu, R.N.; Deng, K.W.; He, F.Y.; Pan, X. Key issues in compatibility of Chinese materia medica compound and its countermeasures through supramolecular chemistry. Chin. Tradit. Herbal Drugs, 2019, 50(12), 2752-2762.
[80]
Li, S.; Zhang, B.; Jiang, D.; Wei, Y.; Zhang, N. Herb network construction and co-module analysis for uncovering the combination rule of traditional Chinese herbal formulae. BMC Bioinformatics, 2010, 11(S11), S6.
[http://dx.doi.org/10.1186/1471-2105-11-S11-S6] [PMID: 21172056]
[81]
Zhang, R.Z.; Yu, S.J.; Bai, H.; Ning, K. TCM-Mesh: The database and analytical system for network pharmacology analysis for TCM preparations. Sci. Rep., 2017, 7(1), 2821.
[http://dx.doi.org/10.1038/s41598-017-03039-7] [PMID: 28588237]
[82]
Xia, Z.; Lv, L.; Di, X.; Xue, J.; Gao, Z.; Zhang, G.; Zhang, H. The compatibility of six alkaloids in ermiao pill explored by a comparative pharmacokinetic and network pharmacological study. Biomed. Chromatogr., 2019, 33(5)e4509
[http://dx.doi.org/10.1002/bmc.4509] [PMID: 30756408]
[83]
Mai, L.Y.; Li, Y.X.; Chen, Y.; Xie, Z.; Li, J.; Zhong, M.Y. Applications of mathematical statistics methods on compatibility researches of traditional Chinese medicines formulae. Zhongguo Zhongyao Zazhi, 2014, 39(10), 1749-1756.
[PMID: 25282876]
[84]
Xu, P.P.; Zhang, F.X.; Fu, L.C.; Li, X.Y.; Zhao, F.; Lai, X.P. A mathematical method for analyzing compatibility law of Chinese herbal formula based on UD-PLS. Chin. Tradit. Herbal Drugs, 2011, 42(4), 819-824.
[85]
Cui, M.; Li, J.; Li, H.; Song, C. Herbal compatibility of traditional Chinese medical formulas for acquired immunodeficiency syndrome. J. Tradit. Chin. Med., 2012, 32(3), 329-334.
[http://dx.doi.org/10.1016/S0254-6272(13)60033-3] [PMID: 23297551]

Rights & Permissions Print Cite
Article Metrics
25
© 2024 Bentham Science Publishers | Privacy Policy