IAEA Activities on ⁶⁷Cu, ¹⁸⁶Re, ⁴⁷Sc Theranostic Radionuclides and Radiopharmaceuticals

Title:IAEA Activities on ⁶⁷Cu, ¹⁸⁶Re, ⁴⁷Sc Theranostic Radionuclides and Radiopharmaceuticals

Volume: 14 Issue: 4

Author(s): Amir R. Jalilian*, Mohamed A. Gizawy, Cyrille Alliot, Sandor Takacs, Sudipta Chakarborty, Mohammad R.A. Rovais, Gaia Pupillo, Kotaro Nagatsu, Jeong H. Park, Mayeen Uddin Khandaker, Renata Mikolajczak, Aleksander Bilewicz, Subhani Okarvi, Katherine Gagnon, Abdul H. Al Rayyes, Suzanne E. Lapi, Valeriia Starovoitova, Aruna Korde and Joao A. Osso

Affiliation:

• Department of Nuclear Sciences and Applications, International Atomic Energy Agency (IAEA), Vienna International Centre, PO Box 100, 1400, Vienna,Austria

Keywords: ⁶⁷Cu, ¹⁸⁶Re, ⁴⁷Sc, IAEA, CRP, theranostic, research reactor, cyclotron.

Abstract: Despite interesting properties, the use of ⁶⁷Cu, ¹⁸⁶Re and ⁴⁷Sc theranostic radionuclides in preclinical studies and clinical trials is curtailed by their limited availability due to a lack of widely established production methods. An IAEA Coordinated Research Project (CRP) was initiated to identify important technical issues related to the production and quality control of these emerging radionuclides and related radiopharmaceuticals, based on the request from IAEA Member States. The international team worked on targetry, separation, quality control and radiopharmaceutical aspects of the radionuclides obtained from research reactors and cyclotrons leading to preparation of a standard recommendations for all Member States. The CRP was initiated in 2016 with fourteen participants from thirteen Member States from four continents. Extraordinary results on the production, quality control and preclinical evaluation of selected radionuclides were reported in this project that was finalized in 2020. The outcomes, outputs and results of this project achieved by participating Member States are described in this minireview.

Cite this article as:

Jalilian R. Amir *, Gizawy A. Mohamed, Alliot Cyrille , Takacs Sandor, Chakarborty Sudipta , Rovais R.A. Mohammad, Pupillo Gaia , Nagatsu Kotaro, Park H. Jeong , Khandaker Uddin Mayeen , Mikolajczak Renata , Bilewicz Aleksander , Okarvi Subhani , Gagnon Katherine , Al Rayyes H. Abdul , Lapi E. Suzanne, Starovoitova Valeriia , Korde Aruna and Osso A. Joao, IAEA Activities on ⁶⁷Cu, ¹⁸⁶Re, ⁴⁷Sc Theranostic Radionuclides and Radiopharmaceuticals, Current Radiopharmaceuticals 2021; 14 (4) . https://dx.doi.org/10.2174/1874471013999200928162322