摘要
地塞米松(Dex)是一种来自类固醇化学组的合成皮质类固醇激素,适用于治疗几种病理疾病,如炎症、自身免疫性疾病和恶性肿瘤。最近对右美托的作用机制及其与其他细胞调节网络可能的相互作用的研究可能有助于解释右美托在癌症治疗中的不一致影响。对必要的转录后调控因子(如micriRNA(miRNAs)的微调调节对调节基本的细胞过程具有必不可少的影响,包括基因表达、细胞增殖、细胞增殖、细胞周期和凋亡。右美斯托似乎通过调节miRNA网络作为癌细胞进展和转移的双刃剑。作为概念的证明,最近的研究已经证明右美托在单独或与其他治疗化合物联合治疗癌症方面是有效的,而一些证据表明右美托在促进癌细胞生存、耐药和转移方面有争议的作用。此外,已经证明其他非编码rna(ncrna)也可以直接或间接地受到Dex的影响。在这篇综述中,我们旨在探讨排毒对癌症相关mirna的有争议的影响。
关键词: 地塞米松、miRNA、癌症、细胞凋亡、侵袭性、耐药性。
Current Molecular Medicine
Title:Correlation Between Dexamethasone and miRNAs in the Regulation of Apoptosis, Drug-resistance, and Metastasis of Cancer Cell
Volume: 21 Issue: 5
关键词: 地塞米松、miRNA、癌症、细胞凋亡、侵袭性、耐药性。
摘要: Dexamethasone (Dex) is a synthetic corticosteroid hormone derived from the steroid chemical group and is applicable in treating several pathological conditions like inflammation, autoimmune disease, and malignancies. Recent investigations on the mechanism of action of Dex and its possible interactions with other cellular regulatory networks may help explain the inconsistent effects of Dex in cancer treatment. Finetuning regulation of essential post-transcriptional regulators such as microRNA (miRNAs) has indispensable impacts on modulating fundamental cellular processes, including gene expression, cell proliferation, cell cycling, and apoptosis. Dex appears to act as a double-edged sword on cancer cell progression and metastasis through regulating miRNA networks. As a proof of concept, recent investigations have proved Dex to be effective in treatment of cancer either individually or in combination with other therapeutical compounds, while several evidences have point to the controversial effects of Dex in the promotion of cancer cell survival, drug-resistance, and metastasis. In addition, it has been proven that other non-coding RNAs (ncRNAs) can also be directly or indirectly affected by Dex. In this review, we aimed to investigate the controversial effect of Dex on the cancer-related miRNAs.
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Cite this article as:
Correlation Between Dexamethasone and miRNAs in the Regulation of Apoptosis, Drug-resistance, and Metastasis of Cancer Cell, Current Molecular Medicine 2021; 21 (5) . https://dx.doi.org/10.2174/1566524020666200925155614
DOI https://dx.doi.org/10.2174/1566524020666200925155614 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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