Abstract
Calcium-activated chloride channels (CaCCs) play fundamental roles in numerous physiological processes. Transmembrane proteins 16A and 16B (TMEM16A/B) were identified to be the best molecular identities of CaCCs to date. This makes molecular investigation of CaCCs become possible. This review discusses the latest findings of TMEM16A/B associated CaCCs, the calcium and voltage dual dependence,the reorganization of Ca2+-binding site, the mechanisms of direct or indirect activation, the structure-functional relationship, and the possible stereoscopic structure. TMEM16A and other members of the family are associated with several kinds of cancers and other chloride channelopathies. An understanding of TMEM16 associated channel proteins will shed some light on their role in oncology and in pharmacology development.
Keywords: CaCCs, Ca2+-binding site, calmodulin, TMEM16A/B.
Protein & Peptide Letters
Title:TMEM16A/B Associated CaCC: Structural and Functional Insights
Volume: 21 Issue: 1
Author(s): Chunli Pang, Hongbo Yuan, Shuxi Ren, Yafei Chen, Hailong An and Yong Zhan
Affiliation:
Keywords: CaCCs, Ca2+-binding site, calmodulin, TMEM16A/B.
Abstract: Calcium-activated chloride channels (CaCCs) play fundamental roles in numerous physiological processes. Transmembrane proteins 16A and 16B (TMEM16A/B) were identified to be the best molecular identities of CaCCs to date. This makes molecular investigation of CaCCs become possible. This review discusses the latest findings of TMEM16A/B associated CaCCs, the calcium and voltage dual dependence,the reorganization of Ca2+-binding site, the mechanisms of direct or indirect activation, the structure-functional relationship, and the possible stereoscopic structure. TMEM16A and other members of the family are associated with several kinds of cancers and other chloride channelopathies. An understanding of TMEM16 associated channel proteins will shed some light on their role in oncology and in pharmacology development.
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Cite this article as:
Pang Chunli, Yuan Hongbo, Ren Shuxi, Chen Yafei, An Hailong and Zhan Yong, TMEM16A/B Associated CaCC: Structural and Functional Insights, Protein & Peptide Letters 2014; 21 (1) . https://dx.doi.org/10.2174/09298665113206660098
DOI https://dx.doi.org/10.2174/09298665113206660098 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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