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Review Article

白藜芦醇，一种具有抗炎和抗癌活性的分子：化学合成的天然产物

卷 28, 期 19, 2021

发表于: 18 September, 2020

页: [3773 - 3786] 页: 14

弟呕挨: 10.2174/0929867327999200918100746

价格: $65

摘要

背景：白藜芦醇是一种天然多酚产物，用于保护植物免受真菌和微生物的侵害。它是天然存在的，尤其是在葡萄、花生和浆果等植物中。它在蓝莓、桑葚、黑莓和红葡萄皮中的浓度最高。白藜芦醇具有多种药理特性，如抗炎、细胞保护和抗肿瘤活性。 方法：我们使用正规工具如谷歌、Reaxys、Scifinder、Scihub和专利Espacenet进行了一项文献调查，以汇编生物合成途径、所有有机合成方法和迄今为止报道的白藜芦醇的生物活性。 结果：本文引用了一百多篇研究文章和专利。其中大约25个与化学合成有关，其余的与白藜芦醇的来源、药理活性和其他性质有关。这项研究表明，许多常见的途径涉及各种药理活性，根据所涉及的途径，这些药理活性可用于治疗各种疾病。诸如Pfitzner-Moffatt氧化、Wittig-Horner缩合、Mizoroki-Heck、Perkin、Wittig等反应已经用于白藜芦醇的合成。基于其类似物和衍生物也建立了构效关系。 结论：除生物合成途径外，本文还综述了已发表的所有白藜芦醇的生物活性和化学合成报道。由于其有价值的生物活性，迄今已报道了各种合成方法。所报道的合成操作适于大规模工业生产。此外，这些综合的合成方法可用于制备芪类化合物和其他相关化合物。

关键词: 白藜芦醇，天然产物，化学合成，抗癌活性，抗炎活性，构效关系(SAR)。

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