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Review Article

糖尿病理论在抗阿尔茨海默病药物研究与开发中的应用。第二部分:cAMP特异性磷酸二酯酶抑制剂的治疗潜力

卷 28, 期 18, 2021

发表于: 17 September, 2020

页: [3535 - 3553] 页: 19

弟呕挨: 10.2174/0929867327666200917125857

价格: $65

摘要

阿尔茨海默病(AD)是一种最常见的与年龄有关的神经退行性疾病，影响个体的认知、行为和日常活动。研究表明，该疾病具有多种病理机制，包括β淀粉样肽的积累、tau蛋白的过度磷酸化、胆碱能神经传递的损伤、中枢神经系统炎症反应的增加。与AD相关的慢性神经炎症与代谢过程紊乱(包括胰岛素释放和葡萄糖代谢)密切相关。由于AD也被称为III型糖尿病，多种具有抗糖尿病作用的化合物已被研究为潜在的治疗其症状和疾病的药物。除了胰岛素和口服降糖药，科学家们还关注了环-3 ''，5 '' -腺苷单磷酸(cAMP)特异性磷酸二酯酶(PDE)抑制剂，它可以调节葡萄糖和相关激素的浓度，并对记忆、情绪和情绪处理产生有益影响。在这篇综述中，我们介绍了最新的关于cAMP特异性PDE4、PDE7和PDE8在血糖和炎症反应控制中的参与，以及PDE抑制剂在治疗AD中的潜在用途的报道。除了体外和体内研究的结果外，本文还介绍了最近的临床试验报告。

关键词: 阿尔茨海默病，PDE抑制剂，抗炎活性，抗糖尿病活性，cAMP，认知障碍，神经炎症，磷酸二酯酶

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