鞘糖脂在癌症中的功能作用

Title:Functional Role of Glycosphingolipids in Cancer

Volume: 28 Issue: 20

关键词: 糖鞘脂、肿瘤相关抗原、GSL 信号、碳水化合物、药物化学、癌症。

摘要: Glycosphingolipids (GSLs) are ubiquitous components on animal cell membranes, and exposed on the outer surface. Various studies have demonstrated that they play key roles in cell proliferation, adhesion, motility and differentiation. Usually, the specific types of GSLs are expressed more highly in tumors than in normal tissues, which are known as tumorassociated antigens. It has been revealed that most tumor cells show altered GSLs patterns on their surface, abnormal GSLs signaling and biosynthesis, which together play a major role in tumor development. Tumor-associated GSL antigens have been used in the development of antitumor vaccines. There is no doubt that GSLs play a crucial role in tumor progression and would be a promising target for cancer treatment.

Cite this article as:

Functional Role of Glycosphingolipids in Cancer, Current Medicinal Chemistry 2021; 28 (20) . https://dx.doi.org/10.2174/0929867327666200831132200