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Case Report

重组人p53腺病毒注射液（rAd-p53）联合化学疗法治疗4例高级别浆液性卵巢癌

卷 20, 期 4, 2020

页: [313 - 320] 页: 8

弟呕挨: 10.2174/1566523220666200826100245

价格: $65

摘要

背景：高度浆液性卵巢癌（HGSOC）是最常见的卵巢上皮癌之一。它具有高度的侵袭性，在全身治疗后很容易复发，并且预后不良。尽管尝试了许多新的化学治疗药物并尝试了不同方案的组合进行治疗，但HGSOC的治疗仍未取得有意义的进展。随着基因测序技术的发展，基因治疗已成为肿瘤治疗的新方向。据报道，P53在HGSOC中具有很高的突变率，这为基因治疗在HGSOC患者中的应用提供了理论基础。重组人p53腺病毒注射液（rAd-p53）是世界上第一个获批的肿瘤基因治疗药物。 病例报告：在本文中，我们回顾性分析了4例用rAdp53治疗的HGSOC患者。其中三例为复发性卵巢癌，其中一例为初始治疗。治疗方法是将重组人p53腺病毒注射液（rAd-p53）应用于病变部位进行局部注射，72小时后，向病变部位注射博来霉素或氟尿嘧啶，同时进行全身静脉内化疗。经rAd-p53治疗后，三种复发性卵巢癌之一达到完全缓解（CR），一种达到部分缓解（PR），一种为稳定疾病（SD）。未经治疗的患者在rAd-p53联合新辅助化疗后进行了手术，获得了病理CR。在P53的各种机制的作用下，随后的肿瘤治疗表现出肿瘤进展缓慢，无腹水和局部复发的特征。截至随访结束，4例患者的OS为71-120个月。 结论：通过这4例病例的显着疗效，我们可以看到，rAdp53联合化学疗法可以有效控制肿瘤病变，延长患者生存时间，提高患者生活质量，为rAd- p53治疗卵巢癌，促进了基因治疗这一领域的进一步发展和进步。

关键词: 高度浆液性卵巢癌，HGSOC，rAd-p53，基因治疗，肿瘤细胞，上皮性卵巢癌。

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