Role of Atypical Chemokines and Chemokine Receptors Pathways in the Pathogenesis of COPD

doi:10.2174/0929867327999200819145327
摘要

慢性阻塞性肺疾病（COPD）代表肺部炎症反应增强，通常是由吸烟引起的炎症细胞募集和激活和/或下呼吸道结构细胞激活引起的。几种介体可以调节这些细胞的激活和募集，特别是那些属于趋化因子（常规和非典型）家族的细胞。新兴证据表明，非典型趋化因子及其受体（例如高迁移率族1号框（HMGB1），抗菌肽，晚期糖基化终产物的受体（RAGE）或toll样受体（TLR））具有复杂的作用。慢性阻塞性肺病，无论是在疾病稳定期间还是在病情恶化期间。这些途径的调节剂代表了COPD的潜在新疗法，许多药物目前处于临床前开发阶段。仅抑制单个非典型趋化因子或受体可能不会阻止炎症过程，因为该网络存在冗余。但是，有许多动物研究鼓励对COPD中非典型趋化因子网络进行调节的研究。因此，很少有制药公司对开发靶向这些分子作为潜在抗炎药的药物保持浓厚兴趣。针对非典型趋化因子和/或其受体的基于抗体的（生物）和基于小分子药物（SMD）的疗法大多处于临床前阶段，并且迫切希望其进入临床试验。这些药物很可能会增强我们对非典型趋化因子在COPD病理生理中作用的认识，从而改善COPD的管理。
关键词: 气道炎症，肺泡巨噬细胞，非典型趋化因子，非典型趋化因子受体，慢性阻塞性肺疾病，淋巴细胞，小气道。
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DOI https://dx.doi.org/10.2174/0929867327999200819145327	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
当代药物化学

非典型趋化因子和趋化因子受体途径在COPD发病中的作用

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当代药物化学

非典型趋化因子和趋化因子受体途径在COPD发病中的作用

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