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Review Article

纳米药物在乳腺癌和卵巢癌化疗中的应用前景:纳米制剂在临床研究中的应用

卷 28, 期 17, 2021

发表于: 19 August, 2020

页: [3271 - 3286] 页: 16

弟呕挨: 10.2174/0929867327666200819115403

价格: $65

摘要

背景：乳腺癌和卵巢癌是全世界妇女的主要健康问题。化疗构成了主要的治疗策略，而纳米载体的使用是一种改进它的好工具。一些纳米制剂已经获得批准，还有一些正在临床试验中，用于治疗这两种类型的癌症。 目的：这篇综述着重分析了目前临床研究中用于治疗这些肿瘤的纳米制剂。 结果：目前，有6种纳米制剂正在进行乳腺癌和卵巢癌的临床试验，其中大多数处于II期和III期。在乳腺癌治疗方面，这些纳米药物含有紫杉醇;对于卵巢癌，含有紫杉醇或喜树碱类似物的纳米制剂正在进行评估。这些抗肿瘤药物的纳米胶囊化便于给药并降低其全身毒性。然而，纳米制剂的最终批准和商业化可能会受到其他方面的限制，比如在体内和体外水平评价的疗效结果之间缺乏相关性，与常规抗肿瘤制剂相比，难以以可重复的方式大批量生产纳米制剂，且生产成本较高。然而，这些挑战并非不可克服，批准用于癌症治疗的纳米制剂的数量正在增加。 结论：总的来说，经过审查的纳米制剂显示出了优异的结果，显示出良好的安全性，更高的最大耐受剂量和类似甚至略优于免费药物的抗肿瘤疗效，加强了纳米化疗在乳腺和卵巢肿瘤中的应用。

关键词: 乳腺癌，喜树碱，化疗，脂质体，纳米载体，卵巢癌，紫杉醇

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