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Review Article

神经生长因子、压力和疾病

卷 28, 期 15, 2021

发表于: 18 August, 2020

页: [2943 - 2959] 页: 17

弟呕挨: 10.2174/0929867327999200818111654

价格: $65

摘要

压力是体内平衡的持续威胁，表现为不同的外在和内在刺激（压力源，汉斯·塞耶的“有害物质”），例如攻击性行为、恐惧、疾病、身体活动、药物、手术损伤以及环境和生理变化。我们的生物体通过激活适应性压力系统来激活补偿反应以恢复体内平衡来应对压力。神经生长因子 (NGF) 被发现是一种信号分子，与交感神经和外周感觉神经元的存活、保护、分化和增殖有关。 NGF 介导压力，在将环境刺激转化为生理和病理反馈方面发挥重要作用，因为 NGF 水平在暴露于压力事件后会发生重要变化。众所周知，心理压力、生活方式压力和氧化压力会增加精神分裂症、重度抑郁症、双相情感障碍、酒精使用障碍和代谢综合征等代谢障碍的风险。这篇综述报告了最近描述 NGF 在与压力相关的精神和代谢障碍中的活性的工作。

关键词: 压力、神经生长因子 (NGF)、精神障碍、代谢综合征、酒精使用障碍、代谢障碍。

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