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Review Article

一篇文献综述:西地那非在癌症联合治疗中的应用

卷 28, 期 11, 2021

发表于: 30 July, 2020

页: [2248 - 2259] 页: 12

弟呕挨: 10.2174/0929867327666200730165338

价格: $65

摘要

药物再利用的概念和西地那非或蓝色药丸多年来紧密联系在一起。事实上，除了最初作为肺系统降压药物的临床应用，西地那非还因其对勃起功能障碍的有益作用而闻名。此外，已有证据支持其在抗癌治疗中的价值，无论是单独使用还是与其他临床有效的化疗药物联合使用。在这篇综述中，我们重点关注了过去和最近的体内和体外研究，这些研究证明了西地那非在多种癌症中联合治疗的细胞和分子基础。我们强调了癌症细胞中不同的分子靶点以及不同的信号通路。西地那非通过一氧化氮(NO)/磷酸二酯酶5型(PDE5)依赖的方式促进细胞凋亡是最常见的机制之一。然而，自噬的激活以及抗肿瘤免疫的调节构成了西地那非触发的其他途径。总的来说，这些研究揭示了西地那非抗癌潜能的复杂性。因此，通过我们的审查，我们的目的是提出一个更新和简化的图片，这种重新利用西地那非在肿瘤学领域。

关键词: 西地那非，药物再利用，PDE-5抑制剂，癌症，联合治疗，癌症治疗

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