A Facile, Efficient Step-Wise and Alternative Synthesis of Indolyl Triazoles via “Click” Chemistry

Title:A Facile, Efficient Step-Wise and Alternative Synthesis of Indolyl Triazoles via “Click” Chemistry

Volume: 18 Issue: 11

Author(s): G. Ganga Reddy, B. Srinivasa Reddy and Ch. Venkata Ramana Reddy*

Affiliation:

• Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, College of Engineering, Kukatpally, Hyderabad, Telangana 500 085,India

Keywords: Knoevengal condensation, 1, 2, 3 triazole, N-propargylation, click chemistry, aryl azides, step-wise and alternative synthesis.

Abstract: series of new 1,2,3 triazoles hybrids were synthesized using a Cu-catalysed azide-alkyne cycloaddition reaction. Thus, a remarkable rapid click reaction of aryl azides with terminal alkynes at room temperature in DMF afforded new 4-((1-((1-(4-methoxy-3-nitrophenyl)-1H-1,2,3-triazol-4- yl)methyl)-1H-indol-3-yl)methylene)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-ones in good to excellent yields. The reaction provides a safe, efficient and economic approach for the synthesis of various 1,2,3 triazoles. The reaction has many advantages like shorter reaction times, good yields of products and isolation of the products without the need for column chromatography. By using knoevenagel reaction under physical grinding with alkylating agents prepared various 1,2,3 triazoles.

Cite this article as:

Reddy Ganga G. , Reddy Srinivasa B. and Reddy Venkata Ramana Ch. *, A Facile, Efficient Step-Wise and Alternative Synthesis of Indolyl Triazoles via “Click” Chemistry, Letters in Organic Chemistry 2021; 18 (11) . https://dx.doi.org/10.2174/1570178617999200711175051