Login Register Cart 0
Generic placeholder image

Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

A Review of Saurauia roxburghii Wall. (Actinidiacaea) as a Traditional Medicinal Plant, Its Phytochemical Study and Therapeutic Potential

Author(s): Afsana Nahrin, Md. Junaid, Syeda Samira Afrose, Muhammad Shaiful Alam, S.M. Zahid Hosen, Rasheda Akter and Tania Sharmin*

Volume 20, Issue 19, 2020

Page: [2036 - 2051] Pages: 16

DOI: 10.2174/1389557520666200709175138

Price: $65

Abstract

Saurauia roxburghii Wall. is an interesting plant, found growing chiefly along the eastern and south-eastern countries of Asia. The various ethnic groups of these regions use the plant as a medication for relieving a wide spectrum of diseases and conditions, including indigestion, boils, fever, gout, piles, eczema, asthma, ulcers, bronchitis, epilepsy, and hepatitis B. This review aims to appraise the vernacular information, botanical characterization, geographical distribution, traditional uses, phytochemistry, and pharmacological activities of S. roxburghii as well as to conduct a critical analysis on the findings. To understand the therapeutic potential and provide an overall idea about the ethnomedicinal practices, phytochemistry, and pharmacological activities of S. roxburghii, relevant information was collected via a library and electronic search of online journals, books, and reputed databases. Phytochemical examination revealed the presence of alkaloids, glycosides, O-glycosides, flavonoids, carbohydrates, saponins, steroids, reducing sugars, tannins, phlobatannins, and triterpenoids. The sterols were identified as Stigmasterol and beta-Sitosterol. The triterpenes were found to be Ursolic acid, Corosolic acid, Maslinic acid, 24-Hydroxy corosolic acid, 3b,7b,24-trihydroxy-urs-12-en-28-oic acid, Oleanolic acid, beta-Amyrin, cis-3-O-p-Hydroxycinnamoyl ursolic acid, trans-3-O-p- Hydroxycinnamoyl ursolic acid, and 7,24-dihydroxyursolic acid. Several in-vivo and in-vitro tests revealed anti-bacterial, anti-cancer, anti-diabetic, anti-oxidant, and anti-viral activities of the plant leaves. Detailed analysis of the information collected on S. roxburghii suggested some promising leads for future drug development. However, many scientific gaps were found in the study of this and further extensive investigation is needed to fully understand the mechanism of action of the active constituents and exploit its therapeutic promises.

Keywords: Saurauia roxburghii, vernacular information, botanical characterization, geographical distribution, traditional uses, phytochemistry, pharmacology.

« Previous Next »
Graphical Abstract

[1]
Ahmed, Y.; Rahman, S.; Akhtar, P.; Islam, F.; Rahman, M.; Yaakob, Z. Isolation of steroids from n-hexane extract of the leaves of Saurauia roxburghii‎. Int. Food Res. J., 2013, 20(5), 2939.
[2]
Ahmed, Y.; Yaakob, Z.; Akhtar, P.; Rahman, M.; Islam, F. In vitro antibacterial and in vivo brine shrimp lethal active compounds isolated from the leaves of Saurauia roxburghii. Int. J. Pharmacol., 2015, 11(7), 821-827.
[http://dx.doi.org/10.3923/ijp.2015.821.827]
[3]
Padmakumar, V.; Haque, N.; Sirie, R.; Khate, K.; Deka, R.P.; Rutsa, V.; Solomon, K. Availability and nutritional value of wild forages as feed for pigs and mithun in Nagaland; India, 2015.
[4]
Uddin, S.N. Traditional uses of Ethnomedicinal plants of the Chittagong Hill Tracts, 1st ed; Bangladesh National Herbarium: Dhaka, 2006.
[5]
Jeong, T-S.; Hwang, E-I.; Lee, H-B.; Lee, E-S.; Kim, Y-K.; Min, B-S.; Bae, K-H.; Bok, S-H.; Kim, S-U. Chitin synthase II inhibitory activity of ursolic acid, isolated from Crataegus pinnatifida. Planta Med., 1999, 65(3), 261-263.
[http://dx.doi.org/10.1055/s-2006-960474] [PMID: 10232075]
[6]
Mazumder, K.; Tanaka, K.; Fukase, K. Cytotoxic activity of ursolic acid derivatives obtained by isolation and oxidative derivatization. Molecules, 2013, 18(8), 8929-8944.
[http://dx.doi.org/10.3390/molecules18088929] [PMID: 23896618]
[7]
Ahmed, Y. Phytochemical and biological investigation on the leaves of Saurauia roxburghii., Post graduate Thesis, Bangladesh University of Engineering and Technology (BUET), 2012.January.
[8]
Cuong, N.M.; Soejarto, D.D.; Li, J. A taxonomic revision of Actinidiaceae of Vietnam. Blumea, 2007, 52(2), 209-243.
[http://dx.doi.org/10.3767/000651907X608981]
[9]
Patiri, B.; Borah, A. Wild edible plants of Assam; Geetakhi Printers and Publishers: Guwahati, 2007.
[10]
Tobgye, T.; Sridith, K. Preliminary notes on distribution of Himalayan plant elements: A case study from Eastern Bhutan. Songklanakarin J. Sci. Technol., 2018, 40(2), 370-378.
[11]
Ngo, T.; Webb, E. Reconciling science and indigenous knowledge in selecting indicator species for forest monitoring. Redefining Diversity & Dynamics of Natural Resources Management in Asia; Shivakoti, G.; Thang, T.; Dung, N.; Hulse, D; Sharma, S., Ed.; Elsevier: Amsterdam, 2017, Vol. 3, pp. 125-138.
[http://dx.doi.org/10.1016/B978-0-12-805452-9.00009-6]
[12]
Rizwana, J.N.; Nazlina, I.; Razehar, A.M.; Noraziah, A.S.; Ling, C.; Muzaimah, S.S.; Farina, A.; Yaacob, W.; Ahmad, I.; Din, L. A survey on phytochemical and bioactivity of plant extracts from Malaysian forest reserves. J. Med. Plants Res., 2010, 4(3), 203-210.
[13]
Srivastava, R. Traditional knowledge of Adi tribe of Arunachal Pradesh on plants. Indian J. Tradit. Knowl., 2009, 8(2), 146-153.
[14]
Sashidhara, K.V.; Singh, S.P.; Singh, S.V.; Srivastava, R.K.; Srivastava, K.; Saxena, J.K.; Puri, S.K. Isolation and identification of β-hematin inhibitors from Flacourtia indica as promising antiplasmodial agents. Eur. J. Med. Chem., 2013, 60, 497-502.
[http://dx.doi.org/10.1016/j.ejmech.2012.12.019] [PMID: 23354072]
[15]
Mishra, B. Vegetation composition and soil nutrients status from polyculture to monoculture. Afr. J. Environ. Sci. Technol., 2011, 5(5), 363-366.
[16]
Singh, S.; Singh, T.P. Plant species diversity and endemism at Dihang Dibang biosphere reserve and its surroundings, Eastern Himalaya biodiversity hotspot. Asian J. Biodivers., 2013, 3(1)
[http://dx.doi.org/10.7828/ajob.v3i1.81]
[17]
Siang, W.; Pradesh, A. Case Study Report Fodder Plants Of Mithun Bos Frontalis Lambert, 1804: A Case Study of. J. Bioresour., 2015, 2(2), 74-78.
[18]
Mozhui, R.; Rongsensashi, L.; Changkija, S. Wild edible fruits used by the tribals of Dimapur district of Nagaland, India. Pleione, 2011, 5(1), 56-64.
[19]
Roy, D.; Nagarajan, R. Biology, Ecology, and Conservation of Golden Langur, Trachypithecus geei. Indian Hotspots; Sivaperuman, C; Venkataraman, K., Ed.; Springer: Singapore, 2018, pp. 251-283.
[http://dx.doi.org/10.1007/978-981-10-6605-4_13]
[20]
Khisha, T.; Karim, R.; Chowdhury, S.R.; Banoo, R. Ethnomedical studies of chakma communities of Chittagong hill tracts, Bangladesh. Bangla. Pharm. J., 2012, 15(1), 59-67.
[21]
Sarwar, A.G. Medicinal plant genetic resources of Bangladesh–genera represented by single species and their conservation needs. Faslnamah-i Giyahan-i Daruyi, 2015, 3(2), 65-74.
[22]
Rahman, M.A.; Uddin, S.; Wilcock, C. Medicinal plants used by Chakma tribe in Hill Tracts districts of Bangladesh. Indian J. Tradit. Knowl., 2007, 6, 508-517.
[23]
Inta, A.; Shengji, P.; Balslev, H.; Wangpakapattanawong, P.; Trisonthi, C. A comparative study on medicinal plants used in Akha’s traditional medicine in China and Thailand, cultural coherence or ecological divergence? J. Ethnopharmacol., 2008, 116(3), 508-517.
[http://dx.doi.org/10.1016/j.jep.2007.12.015] [PMID: 18280071]
[24]
Islam, F.; Rahman, M.S.; Akter, R.; Bakar, M.A.; Abdullah, A.; Uddin Ahmed, N. Antidiabetic and antioxidant effect with phytochemical screening of ethanol extract of Saurauia roxburghii., Pharma. Sci. Monit., 2012, 3(4)..
[25]
Ahmed, Y.; Akhtar, P.; Rahman, S.; Yaakob, Z. Chemical Constituents of Saurauia roxburghii. Chem. Nat. Compd., 2016, 52(5), 953-955.
[http://dx.doi.org/10.1007/s10600-016-1831-0]
[26]
Mazumder, K.; Siwu, E.R.; Nozaki, S.; Watanabe, Y.; Tanaka, K.; Fukase, K. Ursolic acid derivatives from Bangladeshi medicinal plant, Saurauja roxburghii: Isolation and cytotoxic activity against A431 and C6 glioma cell lines. Phytochem. Lett., 2011, 4(3), 287-291.
[http://dx.doi.org/10.1016/j.phytol.2011.04.019]
[27]
Mbambo, B.; Odhav, B.; Mohanlall, V. Antifungal activity of stigmasterol, sitosterol and ergosterol from Bulbine natalensis Baker (Asphodelaceae). J. Med. Plants Res., 2012, 6(38), 5135-5141.
[http://dx.doi.org/10.5897/JMPR12.151]
[28]
Gómez, M.A.; García, M.D.; Sáenz, M.T. Cytostatic activity of Achillea ageratum L. Phytother. Res., 2001, 15(7), 633-634.
[http://dx.doi.org/10.1002/ptr.837] [PMID: 11746850]
[29]
Campos, A.R.; Albuquerque, F.A.; Rao, V.S.; Maciel, M.A.; Pinto, A.C. Investigations on the antinociceptive activity of crude extracts from Croton cajucara leaves in mice. Fitoterapia, 2002, 73(2), 116-120.
[http://dx.doi.org/10.1016/S0367-326X(02)00004-7 ] [PMID: 11978425]
[30]
Mazumder, K.; Tanaka, K.; Siwu, E.; Nozaki, S.; Watanabe, Y.; Fukase, K. Biomimetic oxidative derivatization of ursolic acid by using’Ru’-porphyrin for cytotoxic activity against tumor cell lines. Planta Med., 2012, 78(14), PL37.
[http://dx.doi.org/10.1055/s-0032-1325179]
[31]
Cragg, G.M.; Newman, D.J. Plants as a source of anti-cancer agents. J. Ethnopharmacol., 2005, 100(1-2), 72-79.
[http://dx.doi.org/10.1016/j.jep.2005.05.011] [PMID: 16009521]

Rights & Permissions Print Cite
Article Metrics
15
© 2024 Bentham Science Publishers | Privacy Policy