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Mini-Review Article

胰腺癌中的纳米药物：治疗的新希望

卷 21, 期 15, 2020

页: [1580 - 1592] 页: 13

弟呕挨: 10.2174/1389450121666200703195229

价格: $65

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摘要

在大多数癌症中，胰腺导管腺癌（PDA）的预后最差，死亡率更高。由于缺乏特定的生物标志物，PDA的诊断通常会延迟，并且当前化疗药物的疗效有限。此外，化学疗法通常用于已经发生转移性扩散的晚期阶段。基于纳米技术的系统可以促进PDA的诊断和治疗。新的纳米制剂已显示出可改善常规化学治疗剂（如吉西他滨）和新的抗肿瘤药的活性，保护它们免于降解，提高其选择性，溶解性和生物利用度，并减少其副作用。而且，纳米载体的设计代表了克服耐药性的新方法，这需要对PDA的肿瘤微环境有全面的了解。本文回顾了基于纳米医学的当前观点，以解决胰腺癌治疗的局限性，以及在控制该疾病方面取得进展的未来研究方向。

关键词: 胰腺导管腺癌，化疗药物，纳米颗粒，耐药性，临床试验，吉西他滨。

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