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Review Article

基于Ghrelin的代谢性疾病治疗

卷 28, 期 13, 2021

发表于: 15 June, 2020

页: [2565 - 2576] 页: 12

弟呕挨: 10.2174/0929867327666200615152804

价格: $65

摘要

背景：Ghrelin是胃X / A样细胞分泌的独特的28个氨基酸的肽激素，是生长激素促分泌素受体（GHSR）的内源性配体。已经发现Ghrelin-GHSR信号传导发挥各种生理功能，包括刺激食欲，调节体重，脂质和葡萄糖代谢以及增加肠蠕动和分泌。因此，该系统对于能量稳态至关重要。 目的：本综述的目的是强调基于生长素释放肽-GHSR的肥胖症及其相关代谢性疾病的治疗策略。 结果：针对ghrelin-GHSR途径的代谢紊乱的治疗策略包括抗体和RNA spiegelmers对ghrelin循环中和，ghrelin受体的拮抗剂和反向激动剂的拮抗作用，ghrelin O-酰基转移酶（GOAT）的抑制作用以及潜在的药理作用减少生长素释放肽合成和分泌的方法。 结论：多种针对ghrelin-GHSR系统的化合物在动物和体外干预肥胖和相关代谢紊乱方面显示出有希望的疗效。迫切需要进一步的临床试验，以验证其在人类中的功效。

关键词: Ghrelin，生长激素促分泌素受体（GHSR），治疗策略，肥胖症，体重，食物摄入量。

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