Login Register Cart 0
Generic placeholder image

Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
General Review Article

An Overview on Various Approaches and Recent Patents on Buccal Drug Delivery Systems

Author(s): Monika Targhotra* and Meenakshi K. Chauhan

Volume 26, Issue 39, 2020

Page: [5030 - 5039] Pages: 10

DOI: 10.2174/1381612826666200614182013

Price: $65

conference banner
Abstract

Background: Buccal delivery is an alluring course of organization for fundamental medication conveyance and it leads direct access to the systemic flow through the interior jugular vein sidesteps drugs from the hepatic first-pass digestion gives high bioavailability.

Objective: This article aims at buccal medication conveyance by discussing the structure and condition of the oral mucosa and the novel strategies utilized in evaluating buccal medication ingestion.

Methods: This review highlights the various pharmaceutical approaches for buccal delivery such as buccal tablets, buccal lozenges, buccal micro/nanoparticle, wafer and semisolid dosage forms like chewing gums, buccal patch, buccal gel or ointment and some buccal liquid dosage forms like buccal solutions and buccal sprays and recent patents filed or granted for these approaches.

Results: Recently, some patents are also reported where a combination of various approaches is being employed to achieve very effective mucosal delivery. The various patent search sites were used to collect and analyze the information on buccal drug delivery systems.

Conclusion: The present study provides valuable information, advantages, limitations and future outlook of various buccal drug delivery systems.

Keywords: buccal delivery, oral mucosa, permeation, sublingual, bioadhesive polymers, mucoadhesion.

« Previous Next »
[1]
Gawas SM, Dev A, Deshmukh G, Rathod S. Current approaches in buccal drug delivery system. Pharm Biol Eval 2016; 3: 165-77.
[2]
Murthy V. Buccal film drug delivery system-an innovative and emerging technology-review. J Mol Pharm Org Process Res 2013; 1(3)1000107
[3]
Kaur N. A Review on study of buccal patches: current status of formulation and evaluation methods. J Drug Deliv Ther 2014; 4(3): 69-79.
[http://dx.doi.org/10.22270/jddt.v4i3.870]
[4]
Duchene D, Ponchel G. Bioadhesion of solid oral dosage forms, why and how? Eur J Pharm Biopharm 1997; 44: 15-23.
[http://dx.doi.org/10.1016/S0939-6411(97)00097-0]
[5]
Verma S, Kaul M, Rawat A, Saini S. An overview on buccal drug delivery system. Ind. J. Pharm Sci Res 2011; 2(6): 1303-21.
[6]
Vamanu E, Gatea F. Correlations between microbiota bioactivity and bioavailability of functional compounds: a mini-review. Biomedicines 2020; 8(2)E39
[http://dx.doi.org/10.3390/biomedicines8020039] [PMID: 32093399]
[7]
Piqué N, Berlanga M, Miñana-Galbis D. Health benefits of heat-killed (tyndallized) probiotics: an overview. Int J Mol Sci 2019; 20(10): 2534.
[http://dx.doi.org/10.3390/ijms20102534] [PMID: 31126033]
[8]
Markowiak P, Śliżewska K. Effects of probiotics, prebiotics, and synbiotics on human health. Nutrients 2017; 9(9): 1021.
[http://dx.doi.org/10.3390/nu9091021] [PMID: 28914794]
[9]
Zimmermann A, Hofer S, Pendl T, Kainz K, Madeo F, Carmona-Gutierrez D. Yeast as a tool to identify anti-aging compounds. FEMS Yeast Res 2018; 18(6): 18.
[http://dx.doi.org/10.1093/femsyr/foy020] [PMID: 29905792]
[10]
Shimojo Y, Ozawa Y, Toda T, Igami K, Shimizu T. Probiotic Lactobacillus paracasei A221 improves the functionality and bioavailability of kaempferol-glucoside in kale by its glucosidase activity. Sci Rep 2018; 8(1): 9239.
[http://dx.doi.org/10.1038/s41598-018-27532-9] [PMID: 29915223]
[11]
Dos Santos AS, de Albuquerque TMR, de Brito Alves JL, de Souza EL. Effects of quercetin and resveratrol on in vitro properties related to the functionality of potentially probiotic lactobacillus strains. Front Microbiol 2019; 10: 2229.
[http://dx.doi.org/10.3389/fmicb.2019.02229] [PMID: 31608042]
[12]
Mansoorian B, Combet E, Alkhaldy A, Garcia AL, Edwards CA. Impact of fermentable fibres on the colonic microbiota metabolism of dietary polyphenols rutin and quercetin. Int J Environ Res Public Health 2019; 16(2): 292.
[http://dx.doi.org/10.3390/ijerph16020292] [PMID: 30669671]
[13]
Trakooncharoenvit A, Tanaka S, Mizuta E, Hira T, Hara H. Water-soluble dietary fibers enhance bioavailability of quercetin and a fiber derived from soybean is most effective after long-term feeding in rats. Eur J Nutr 2019; 11.
[PMID: 31079173]
[14]
Sinagra E, Tomasello G, Cappello F, et al. Probiotics, prebiotics and symbiotics in inflammatory bowel diseases: state-of-the-art and new insights. J Biol Regul Homeost Agents 2013; 27(4): 919-33.
[PMID: 24382173]
[15]
Sinagra E, Tomasello G, Raimondo D, et al. Nutrition, malnutrition and dietary interventions in inflammatory bowel disease. Prog Nutr 2014; 16: 79-89.
[16]
Shojaei AH. Buccal mucosa as a route for systemic drug delivery: A review. J Pharm Pharm Sci 1998; 1(1): 15-30.
[PMID: 10942969]
[17]
Salamat-Miller N, Chittchang M, Johnston TP. The use of mucoadhesive polymers in buccal drug delivery. Adv Drug Deliv Rev 2005; 57(11): 1666-91.
[http://dx.doi.org/10.1016/j.addr.2005.07.003] [PMID: 16183164]
[18]
Chinna Reddy P, Chaitanya KS, Madhusudan Rao Y. A review on bioadhesive buccal drug delivery systems: current status of formulation and evaluation methods. Daru 2011; 19(6): 385-403.
[PMID: 23008684]
[19]
Venkatalakshmi R, Sudhakar Y. Buccal drug delivery using adhesive polymeric patches. Ijpsr Res 2012; 3(1): 35-41.
[20]
Patel J, Solanki SS, Patel K, Patel MP, Patel JK. Buccal drug delivery system Available at: https://www.slideshare.net/rasikaw alunj/buccaldrugdeliverysytem52214748#:~:text=Buccal%20drug%20delivery%20system%20%E2%80%A2,and%20removal%20of%20dosage%20from
[21]
Bobade NN, Atram SC, Wankhade VP, Pande DS, Tapar DK. A review on buccal drug delivery system. Semantic Scholar 2013. Available at: https://www.semanticscholar.org/paper/AReviewonBuccalDrugDeliverySystemBobadeAtram/8439c17fd775a84a706868a8744314186f99d22e
[22]
Prabhu S, Parsekar SD, Shetty A, Monteiro S, Azharuddin M. A review on fast dissolving sublingual films for systemic drug delivery Semantic Scholar 2014. Available at: https://www.semanticscholar.org/paper/Review-Article-A-Review-on-Fast-Dissolving-Films-Prabhu-Parsekar/ec332e150e6a43c6df43eb042c2245f314e5cf71
[23]
Puratchikody Ayarivan, Prasanth V. Mathew Sam, Balaraman Kumar. Buccal drug delivery: past, present and future -a review. Int J Drug Deliv 2011; 3: 171-84.
[24]
Kigasawa , et al. inventor; Grelan Pharmaceutical Co, Ltd, assignee Soft Buccal United States patent US 4572832 1986.
[25]
Chin H, Janice L Cacace. inventor; Schering Corporation, Kenilworth, NJ, assignee Buccal Formulation United States patent US 4755386. 1988 July;
[26]
Sugden K Beverley, Britain G. inventor; Reckitt and Colman Products Limited, assignee Buccal Tablet comprising Etorphine United States patent US 4829056 1989 May;
[27]
Gallopo I. Inventor. Tablets with Improved Bioadhesion to mucous membranes United States patent US 4915948. 1990 April;
[28]
Balkin . inventor Oral Transmucosal Delivery Tablet and Method of Making it United States patent US 5656284 1997 Aug;
[29]
Dittgen M Timpe, et al. Inventor; enapharm GmbH and Co KG, 24 assignee Bioadhesive Tablet United States patent US 6063404A 2000 May;
[30]
Rault I. inventor; Permatec Technologie AG, assignee Bioadhesive Tablets United States patent US 6242004B1 2001 Jun;
[31]
Levine LH Bologna, et al. al inventor; Columbia laboratorieres, Assignee Bioadhesive Progressive Hydration Tablets and Methodsof Making and using the same United States patent US 6248358B1 2001 Jun;
[32]
Robinson JR Panther, et al. inventor; Cima Labs Inc, assignee Effervescent Drug Delivery System for Oral Administration United States patent US 6391335B1 2002 May;
[33]
Capella . inventor; Warner-Lambert Company, assignee Compressed Nitroglycern Tablet and its method of Manufactureus United States patent US 6500456B1 2002 Dec;
[34]
Levine LH Bologna, et al. inventor; Columbia Laboratories, Inc, assignee Bioadhesive Progressive Hydration Tablets United States patent US 6624200B2 2003 Sep;
[35]
Selvaraj B, Jobdevairakkam Christopher N. inventor; Navinta LLC, assignee Composition of Fentanyl Citrate Oral Solid Transmucosal Dosage Form, Excipient and Binding Material Therefore and methods of making United States patent US 2007/0104763 A1 2007 May;
[36]
Myers Garry L, Hariharan M. Inventor Orally Administrable FilmDosage forms containing Ondansetron World Intellectual Property Organization WO 090694 Al 2011 July;
[37]
Chen . inventor; GlaxoSmithKline, LLC, assignee Nicotine Lozenge Composition United States patent US 8940772 B2 2015 Jan;
[38]
Crowley KL. inventor Buccal and Sublingual Cannabinoid formulations and method of making the same United States patent US 9675656 B2 2017 June;
[39]
Yatvin Milton B. inventor Liposome Drug Delivery World Intellectual Property Organization WO 01/82897A2 2001 Nov;
[40]
Mitragotri Samir. inventor A New Method for Oral Delivery World Intellectual Property Organization WOO3/007913A2 2003 Jan;
[41]
De Los RM. inventor; Cullman Louis, C.; assignee. Self Assemble Nanoparticle Drug Delivery System. World Intellectual Property Organization WO 2006; 2006/033679: A2.
[42]
David , et al. inventor Mucoadhesive Nanocomposite Delivery System United States patent US 2009/0232899A1 2009 Sep;
[43]
Goldberg M, Alonso N, Maria J. Chen, Kuan-Jutargeted inventor; PABST, Pagtrea L.; assignee. Buccal Delivery. World Intellectual Property Organization WO 2014; 2014/130866: A2.
[44]
Shridhar GS, Manohar SD, Bhanudas RS. Mucoadhesive buccal drug delivery: an overview. J Adv Pharm Educ Res 2013; 3: 319-32.
[45]
David M. inventor; Reinhardt, Gerard, E; assignee Rapidly Absorbing Oral Formulations of Pde5 Inhibitor WO 2007/002125 Al 2007 Jan;
[46]
Modi P. inventor; Fenwafe Inc, assignee Wafer Formulation US 8623401 B2 2014 Jan;
[47]
Cherukuri Subraman, R Vienna, Pinney John, M Bethesda, Henningfield , Jack E. Inventor medicated chewing gum delivery system for nicotine PCT/US1999/020105. 1999.
[48]
Lao Andersen, Szemán My Ly. Szemán, inventor Comprising Cyclodextrin Inclusion Complex with Higher Stability PCT/DK2008/000264 2001.
[49]
Corbo , et al. Inventor Taste Masking Composition United States patent US 2007/0122475A1. 2007 May;
[50]
Foster , et al. inventor Medicate Chewing Gum United States patent US 2010/0209359 A1 2010.
[51]
Crawford , et al. inventor Tobacco-Free Oral Flavor Delivery Pouch Product US 2013/0236605 A1 2013.
[52]
Hassan N, Keith F, Peter H. Homogeneous Paste and Gel Formulations. World Intellectual Property Organization WO 2008; 2008/077130: A2.
[53]
Feldschuh Mark. inventor Oral Anaesthetic Gel World Intellectual Property Organization WO/2005/067865 A1 2005.
[54]
Macalister Don. inventorTopical Oral Gel Formulations for Dental Usage World Intellectual Property Organization WO 2011/078700Al 2011 June;
[55]
Alejandro Z, Atherton Calif. inventor; ALZA Corporation, assignee Therapeutic Adhesive Patch United States patent US 3699963 1972 Oct;
[56]
Ian R, Flockhart . inventor; Corint, Ltd, assignee Desmopressin Buccal Patch Composition United States patent US 5298256 1994 March;
[57]
Lerner , et al. inventor; Perio Products Ltd,assignee Pharmaceutical Oral Patch for Controlled Release of Pharmaceutical agents in the oral cavity United States patent US 6197331 B1 2001 March;
[58]
Yoshinaga , et al. inventor Oral Cavity Patch United States patent US 2016/0113877 A1 2016.
[59]
Tapolsky , et al. Inventor; Virotex Corporation,assignee Bioerodable Film for delivery of Pharmaceutical Compounds of Mucosal Surfaces United States patent US 6159498 2000 Dec;
[60]
Fankhauser , et al. inventor Distengrable Oral Films United States patent US2007/0202057 A1 2007.
[61]
Myers , et al. inventor Sublingual and Buccal Film Compositions United States patent US 8475832 B2 2013.
[62]
Haber , et al. inventor; Biota Ltd,assignee Orally Administrable Films and Preparation thereof United States patent US 8840935 B2 2014 Sep;
[63]
Myers , et al. inventor; Indivior UK Limited,assignee Sublingual and Buccal Film Composition United States patent US 9687454B2 2017 June;
[64]
Yang , et al. inventor Sublingual and Buccal Film Compositions United States patent US 2019/0046411 A1 2019.
[65]
Pathan SA, Iqbal Z, Sahani JK, Talegaonkar S, Khar RK, Ahmad FJ. Buccoadhesive drug delivery systems--extensive review on recent patents. Recent Pat Drug Deliv Formul 2008; 2(2): 177-88.
[http://dx.doi.org/10.2174/187221108784534135] [PMID: 19075906]
[66]
Dugger III. inventor; Flemington Pharmaceuticals Co,assigneeBuccal Polar Spray or Capsule United States patent US6110486 2000 Aug;
[67]
Brian W, Geoffrey G. inventor Liquid Spray Formulations for Buccal Delivery of Cannabinoids European Patent Specification, EP 1361 864 B9 2014 July;
[68]
Dugger III, et al. inventor; Novadel Pharma Inc,assignee Buccal Polar and Non-Polar Spray Containing Zolpidem United States patent US 8236285B2 2012 Aug;
[69]
Parab , et al. inventor; Bristol-Myers Squibb Company, assignee Aripiprazole Oral Solution United States patent US 6977257 B2 2005 Dec;
[70]
Montenegro-Nicolini M, Morales JO. Overview and future potential of buccal mucoadhesive films as drug delivery systems for biologics. AAPS PharmSciTech 2017; 18(1): 3-14.
[http://dx.doi.org/10.1208/s12249-016-0525-z] [PMID: 27084567]

Rights & Permissions Print Cite
Article Metrics
30
© 2024 Bentham Science Publishers | Privacy Policy