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Current Genomics

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ISSN (Print): 1389-2029
ISSN (Online): 1875-5488

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General Review Article

Hypothetical Proteins as Predecessors of Long Non-coding RNAs

Author(s): Girik Malik, Tanu Agarwal, Utkarsh Raj, Vijayaraghava Seshadri Sundararajan, Obul Reddy Bandapalli* and Prashanth Suravajhala*

Volume 21, Issue 7, 2020

Page: [531 - 535] Pages: 5

DOI: 10.2174/1389202921999200611155418

Price: $65

Abstract

Hypothetical Proteins [HP] are the transcripts predicted to be expressed in an organism, but no evidence of it exists in gene banks. On the other hand, long non-coding RNAs [lncRNAs] are the transcripts that might be present in the 5’ UTR or intergenic regions of the genes whose lengths are above 200 bases. With the known unknown [KU] regions in the genomes rapidly existing in gene banks, there is a need to understand the role of open reading frames in the context of annotation. In this commentary, we emphasize that HPs could indeed be the predecessors of lncRNAs.

Keywords: Hypothetical proteins, lncRNA, aptamers, annotation, functional genomics, transcripts.

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