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Review Article

基于BRD4的双靶标抑制剂：新型的癌症治疗方法

卷 28, 期 9, 2021

发表于: 10 June, 2020

页: [1775 - 1795] 页: 21

弟呕挨: 10.2174/0929867327666200610174453

价格: $65

摘要

背景：目前，癌症继续对公共健康构成急剧增加和严重的威胁。虽然近年来已经开发出了许多抗肿瘤药物，但患者的存活率并不令人满意。癌症患者的预后差与耐药性的发生密切相关。因此，我们急需制定治疗癌症的新策略。多靶疗法的目的是具有添加剂或协同效应，并通过将不同的药物毒团整合到一个单一的药物分子中，降低耐药性发展的潜力。鉴于大多数疾病在本质上是多因素的，多目标疗法的强度越来越提高，这改善了疾病模型的结果，并获得了几种已进入临床试验的化合物。因此，我们有可能利用这种策略来治疗与BRD4相关的癌症。本文综述了基于BRD4的双靶抑制剂在抗肿瘤方面的最新研究进展。 方法：从在线资源和数据库中检索了有关BRD4抑制剂的文献

关键词: BRD4，抗癌，组合，药物设计，双靶标，酶促/非酶促蛋白。

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