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Review Article

通过递送载体平台提高生物活性分子的治疗功效

卷 28, 期 14, 2021

发表于: 05 June, 2020

页: [2697 - 2706] 页: 10

弟呕挨: 10.2174/0929867327666200605154506

价格: $65

摘要

药物必须克服许多障碍才能达到其理想的治疗目标。在一些情况下，药物，尤其是高度亲脂性的分子，具有低溶解度和生物利用度的问题，因此它们所需的靶向性受到阻碍。此外，可能会产生不需要的代谢产物或可能识别出脱靶。沿着这些路线，纳米药理学提供了新的技术平台，以克服这些界限。具体来说，许多载体平台如环糊精和杯芳烃已被广泛用于宿主亲脂性药物，如血管紧张素 II AT1 受体 (AT1R) 拮抗剂，以及槲皮素和水飞蓟宾。将这些药物封装在超分子或其他系统中可以改善它们的溶解度和代谢稳定性，增加它们的选择性，从而降低它们的有效剂量并提高它们的治疗指数。在这篇小型综述中，我们报告了水飞蓟宾和 AT1R 拮抗剂坎地沙坦在 2-HP-β-环糊精宿主分子中的制剂，它们分别显示出增强的细胞毒性和增加的水飞蓟宾和坎地沙坦的稳定性。此外，我们描述了槲皮素在带有杯芳烃超分子宿主的金纳米颗粒中的封装。此外，已经描述了替莫唑胺在杯芳烃纳米胶囊中的包封。最后，我们报告了使用这些配方所实现的活性增强，以及我们用来表征这些配方并探索宿主和探索分子之间的分子相互作用的分析和计算方法。

关键词: 纳米技术、杯芳烃、环糊精、AT1 拮抗剂、槲皮素、咖啡酸、迷迭香酸、水飞蓟宾、替莫唑胺。

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