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Current Stem Cell Research & Therapy

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ISSN (Print): 1574-888X
ISSN (Online): 2212-3946

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Review Article

Nanomaterials-based Cell Osteogenic Differentiation and Bone Regeneration

Author(s): Tianxu Zhang, Yang Gao, Weitong Cui, Yanjing Li, Dexuan Xiao and Ronghui Zhou*

Volume 16, Issue 1, 2021

Published on: 21 May, 2020

Page: [36 - 47] Pages: 12

DOI: 10.2174/1574888X15666200521083834

Price: $65

Abstract

With the rapid development of nanotechnology, various nanomaterials have been applied to bone repair and regeneration. Due to the unique chemical, physical and mechanical properties, nanomaterials could promote stem cells osteogenic differentiation, which has great potentials in bone tissue engineering and exploiting nanomaterials-based bone regeneration strategies. In this review, we summarized current nanomaterials with osteo-induction ability, which could be potentially applied to bone tissue engineering. Meanwhile, the unique properties of these nanomaterials and their effects on stem cell osteogenic differentiation are also discussed. Furthermore, possible signaling pathways involved in the nanomaterials- induced cell osteogenic differentiation are also highlighted in this review.

Keywords: Nanomaterials, stem cells, osteogenic differentiation, bone regeneration, oste-induction, nanotechnology.

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