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代谢油墨乳酸调节表观瘤环境：致癌过程中肿瘤微环境和大环境的协调作用。

卷 21, 期 3, 2021

发表于: 21 May, 2020

页: [177 - 181] 页: 5

弟呕挨: 10.2174/1566524020666200521075252

摘要

肿瘤异质性受多种因素影响，包括遗传，表观遗传和代谢表观基因调控的轴。近年来，代谢表观基因组重编程已被认为是许多肿瘤的标志之一，它似乎受微观环境和宏观环境因素（包括饮食，微生物群和环境压力）的驱动。从表观上看，组蛋白赖氨酸残基可通过各种翻译后修饰（PTM）进行修饰，例如乙酰化，酰化，甲基化和乳化。此外，建议将乳酸化作为PTM的一种新形式，该形式使用乳酸底物作为表观遗传组蛋白重组组蛋白的代谢油墨。因此，需要进行临床前和临床尝试来破坏代谢表观基因组重编程的途径，该途径会将促肿瘤微环境转变为抗肿瘤微环境。本文重点介绍了肿瘤微环境中的代谢表观基因调控事件，包括乳糖化及其代谢底物乳酸。

关键词: 代谢物，表观基因组，癌症，微环境，饮食，乳酸。

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