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Review Article

调节Toll样受体和免疫系统的热激蛋白可能是黑色素瘤的新型治疗靶点。

卷 21, 期 1, 2021

发表于: 11 May, 2020

页: [15 - 24] 页: 10

弟呕挨: 10.2174/1566524020666200511091540

价格: $65

摘要

黑色素瘤是一种严重的皮肤癌，在黑色素细胞中发展。尽管它不像其他一些皮肤癌那么普遍，但是如果不及早治疗，它的危险性会更大，因为它能够迅速扩散到其他器官。热激蛋白（HSP）是幼稚蛋白的细胞内分子伴侣，可在应激条件下被诱导。 HSP被释放到细胞外环境中，并与Toll样受体（TLR）结合以调节免疫应答，例如细胞因子和趋化因子的释放。 HSP可以与主要组织相容性复合体（MHC）I类抗原交叉呈递，并与肿瘤特异性抗原结合。 TLR是先天免疫系统受体，通过HSP激活参与黑色素瘤生长途径。黑色素细胞表达TLR4和TLR9来调节免疫反应。许多TLR配体被认为是合适的佐剂，因为它们可以激活树突状细胞。针对某些TLR，例如TLR7和TLR9，是治疗黑色素瘤的一种可用选择。在这篇综述中，我们旨在确定黑色素瘤中TLR和HSP组之间的关系。

关键词: HSP，TLR，免疫系统，治疗目标，预后因素，黑色素瘤。

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