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Review Article

表没食子儿茶素没食子酸酯(EGCG)对癌症的表观遗传修饰

卷 21, 期 11, 2020

页: [1099 - 1104] 页: 6

弟呕挨: 10.2174/1389450121666200504080112

价格: $65

摘要

在绿茶的主要成分中，表没食子儿茶素-3-没食子酸酯(EGCG)是最有效的抗癌特性。大量的研究提供了EGCG抑制功能的机制，EGCG通过激活/抑制多种信号通路参与了肿瘤细胞周期、发育和凋亡的改变。EGCG在癌症中发挥多重作用的另一个机制是DNA甲基化或甲基转移酶、组蛋白乙酰化或去乙酰化酶以及非编码RNA(micoRNAs)的表观遗传学改变。此外，miRNA转录的反调控表达已被证实可被致癌和肿瘤抑制转录因子直接调控。近年来，EGCG已经鉴定出一些蛋白为miRNA直接相互作用体。然而，EGCG调控miRNA的机制尚未完全被了解。本文综述了EGCG在多种癌症以及致癌和抑癌转录因子中调控表观遗传变化的研究进展。

关键词: 表没食子儿茶素没食子酸盐(EGCG)， micoRNA，癌症，表观遗传调节，甲基转移酶，miRNA

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