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Review Article

晚期肝细胞癌的当前转化和临床挑战

卷 27, 期 29, 2020

页: [4789 - 4805] 页: 17

弟呕挨: 10.2174/0929867327666200422143847

价格: $65

摘要

肝细胞癌(HCC)是世界范围内一种常见且日益增加的癌症相关死亡原因。肝硬化的病因多种多样，存在分子遗传和临床异质性，且常在晚期出现，这使得扭转这一趋势变得复杂。大规模基因组研究已经确定了导致HCC发展和进展的关键信号通路的改变，但是这些发现还没有直接影响临床环境中的患者管理。尽管存在这些转化上的挑战，但在最近的随机试验中，少数抗血管生成系统治疗药物已经成功地丰富了晚期HCC可用治疗方案。此外，免疫检查点抑制的早期前景现在正处于改变标准系统治疗算法的前沿。本文综述了近年来在转化和临床方面的进展，这些进展促进了目前的实践，并探讨了在改善被诊断为晚期HCC患者预后和治疗经验方面所面临的挑战。

关键词: 肝细胞癌，翻译研究，基因组分析，靶向药物，免疫检查点抑制。

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