Abstract
Diabetes and osteoporosis are two common diseases with different complications. Despite different therapeutic strategies, managing these diseases and reducing their burden have not been satisfactory, especially when they appear one after the other.
In this review, we aimed to clarify the similarity, common etiology and possible common adjunctive therapies of these two major diseases and designate the known molecular pattern observed in them.
Based on different experimental findings, we want to illuminate that interestingly similar pathways lead to diabetes and osteoporosis. Meanwhile, there are a few drugs involved in the treatment of both diseases, which most of the time act in the same line but sometimes with opposing results. Considering the correlation between diabetes and osteoporosis, more efficient management of both diseases, in conditions of concomitant incidence or cause and effect condition, is required.
Keywords: Diabetes, osteoporosis, similar etiology, similar pathways, drug-induced complications, immune system.
[http://dx.doi.org/10.1371/journal.pone.0161897] [PMID: 27564383]
[http://dx.doi.org/10.4239/wjd.v6.i3.489] [PMID: 25897358]
[http://dx.doi.org/10.1371/journal.pone.0164807] [PMID: 27741306]
[http://dx.doi.org/10.1007/978-3-319-54016-0_15]
[http://dx.doi.org/10.3390/nu8060347] [PMID: 27338453]
[http://dx.doi.org/10.1589/jpts.27.179] [PMID: 25642068]
[http://dx.doi.org/10.1016/j.rdc.2015.08.005] [PMID: 26611558]
[http://dx.doi.org/10.1016/j.diabres.2015.02.010] [PMID: 25765669]
[http://dx.doi.org/10.1016/j.ecl.2016.09.010] [PMID: 28131137]
[http://dx.doi.org/10.1109/ICBK.2018.00037]
[http://dx.doi.org/10.1080/14740338.2018.1524868] [PMID: 30222369]
[http://dx.doi.org/10.1007/s40264-015-0339-z] [PMID: 26370106]
[http://dx.doi.org/10.1186/1472-6823-14-33] [PMID: 24721668]
[http://dx.doi.org/10.1016/j.jdiacomp.2007.06.004] [PMID: 18413190]
[http://dx.doi.org/10.1055/s-2001-18605] [PMID: 11460594]
[http://dx.doi.org/10.1016/j.jdiacomp.2011.02.004] [PMID: 21458300]
[http://dx.doi.org/10.2174/1874312901812010050] [PMID: 29755605]
[http://dx.doi.org/10.1111/j.1464-5491.2008.02608.x] [PMID: 19125760]
[http://dx.doi.org/10.1007/s00198-014-2986-9] [PMID: 25488807]
[http://dx.doi.org/10.1089/biores.2016.0045] [PMID: 28736691]
[http://dx.doi.org/10.1007/s40618-018-0828-x] [PMID: 29353395]
[http://dx.doi.org/10.1016/j.bbrc.2018.12.112] [PMID: 30579598]
[http://dx.doi.org/10.3892/ijmm.2016.2794] [PMID: 27840967]
[PMID: 26722385]
[http://dx.doi.org/10.1083/jcb.200204046] [PMID: 12379806]
[http://dx.doi.org/10.1210/en.2006-0700] [PMID: 16973725]
[http://dx.doi.org/10.1677/joe.0.1340485] [PMID: 1402554]
[http://dx.doi.org/10.1359/jbmr.081001]
[http://dx.doi.org/10.1677/joe.1.06141] [PMID: 15930167]
[http://dx.doi.org/10.1002/jcb.21573] [PMID: 17975793]
[http://dx.doi.org/10.1016/j.lfs.2018.04.042] [PMID: 29702126]
[http://dx.doi.org/10.1359/jbmr.1998.13.1.96] [PMID: 9443795]
[http://dx.doi.org/10.1002/jcp.20804] [PMID: 16972249]
[http://dx.doi.org/10.1007/s00198-016-3598-3] [PMID: 27080706]
[http://dx.doi.org/10.2337/db14-1611] [PMID: 25633418]
[http://dx.doi.org/10.18004/rvspmi/2312-3893/2018.05(02)38-044]
[PMID: 28843238]
[http://dx.doi.org/10.4143/crt.2015.464]
[http://dx.doi.org/10.2337/db14-1192] [PMID: 25552599]
[http://dx.doi.org/10.1016/j.lfs.2015.11.017] [PMID: 26606859]
[http://dx.doi.org/10.1172/JCI116788] [PMID: 8408647]
[http://dx.doi.org/10.1172/JCI111141] [PMID: 6355186]
[http://dx.doi.org/10.1007/s00125-006-0560-5] [PMID: 17242918]
[http://dx.doi.org/10.1111/ceo.12375] [PMID: 24995479]
[http://dx.doi.org/10.1097/IJG.0000000000000209] [PMID: 25651206]
[http://dx.doi.org/10.1016/j.amjmed.2011.05.024] [PMID: 22195528]
[http://dx.doi.org/10.1002/14651858.CD001347.pub2]
[http://dx.doi.org/10.1016/j.tem.2006.03.009] [PMID: 16678739]
[http://dx.doi.org/10.4081/reumatismo.2017.922] [PMID: 28535619]
[http://dx.doi.org/10.1172/JCI2799] [PMID: 9664068]
[http://dx.doi.org/10.1074/jbc.M111.283481] [PMID: 22030390]
[http://dx.doi.org/10.1007/s00774-008-0019-5] [PMID: 19066717]
[http://dx.doi.org/10.1002/(SICI)1097-4644(19990901)74:3<357:AID-JCB5>3.0.CO;2-7] [PMID: 10412038]
[http://dx.doi.org/10.1177/1535370213519215] [PMID: 24510055]
[http://dx.doi.org/10.1186/1479-5876-12-168] [PMID: 24929254]
[http://dx.doi.org/10.1210/endo.140.10.7034] [PMID: 10499489]
[http://dx.doi.org/10.1002/jbmr.160] [PMID: 20564240]
[http://dx.doi.org/10.1136/annrheumdis-2015-207240] [PMID: 26113650]
[http://dx.doi.org/10.1016/j.devcel.2011.08.016] [PMID: 22055344]
[http://dx.doi.org/10.1074/jbc.M112.444190] [PMID: 23645674]
[http://dx.doi.org/10.1007/s00418-014-1194-1] [PMID: 24553790]
[http://dx.doi.org/10.1007/s00198-015-3325-5] [PMID: 26395886]
[http://dx.doi.org/10.4161/auto.7.1.13044] [PMID: 20935516]
[http://dx.doi.org/10.2337/db12-1474] [PMID: 23274896]
[http://dx.doi.org/10.1089/dna.2014.2755] [PMID: 25665094]
[http://dx.doi.org/10.1007/s12020-014-0506-5] [PMID: 25649760]
[http://dx.doi.org/10.1172/JCI3914] [PMID: 9788977]
[http://dx.doi.org/10.1007/s00198-009-0917-y] [PMID: 19350340]
[http://dx.doi.org/10.20517/2574-1209.2018.27]
[http://dx.doi.org/10.1016/j.healun.2013.01.498]
[http://dx.doi.org/10.1371/journal.pone.0143405] [PMID: 26599323]
[http://dx.doi.org/10.1016/j.nefroe.2015.06.006 ] [PMID: 26299169]
[http://dx.doi.org/10.1111/ajt.14323] [PMID: 28432716]
[http://dx.doi.org/10.3904/kjim.2015.394] [PMID: 27688296]
[http://dx.doi.org/10.1007/s00223-007-9040-2] [PMID: 17612778]
[http://dx.doi.org/10.1016/S0140-6736(00)04765-6] [PMID: 11386321]
[http://dx.doi.org/10.1093/ndt/gfr214] [PMID: 21622987]
[http://dx.doi.org/10.1016/j.ecl.2007.07.008] [PMID: 17983930]
[http://dx.doi.org/10.1056/NEJM196002252620807] [PMID: 13850721]
[http://dx.doi.org/10.1007/s11892-018-0976-6] [PMID: 29399724]
[http://dx.doi.org/10.1161/01.HYP.0000231552.10054.aa] [PMID: 16801488]
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.108.119438] [PMID: 18981326]
[http://dx.doi.org/10.1001/archinte.1964.00280090091014] [PMID: 14096393]
[http://dx.doi.org/10.1016/S2213-8587(15)00377-0] [PMID: 26489809]
[http://dx.doi.org/10.1016/0026-0495(82)90115-9] [PMID: 7078423]
[http://dx.doi.org/10.7326/0003-4819-118-9-199305010-00002] [PMID: 8489642]
[http://dx.doi.org/10.1007/s00198-018-4486-9] [PMID: 29574519]
[http://dx.doi.org/10.1016/j.jbspin.2003.09.009] [PMID: 14769521]
[http://dx.doi.org/10.1111/joim.12397] [PMID: 26223424]
[http://dx.doi.org/10.2147/DDDT.S179568] [PMID: 30532521]
[http://dx.doi.org/10.1016/j.mehy.2009.02.010] [PMID: 19304401]
[http://dx.doi.org/10.1007/s00125-009-1390-z] [PMID: 19455306]
[http://dx.doi.org/10.3122/jabfm.2012.01.100161] [PMID: 22218624]
[http://dx.doi.org/10.1007/s40618-013-0040-y] [PMID: 24682913]
[http://dx.doi.org/10.1210/jc.2012-1720] [PMID: 22904177]
[http://dx.doi.org/10.1097/MD.0000000000004195] [PMID: 27428221]
[http://dx.doi.org/10.3727/096368908786092775] [PMID: 18819251]
[http://dx.doi.org/10.1210/en.2011-0066] [PMID: 21558313]
[http://dx.doi.org/10.1530/JOE-14-0222] [PMID: 25122000]
[http://dx.doi.org/10.3727/096368910X557263] [PMID: 21396168]
[http://dx.doi.org/10.1016/j.amjmed.2011.01.007] [PMID: 21605729]
[http://dx.doi.org/10.1503/cmaj.071330] [PMID: 18695179]
[http://dx.doi.org/10.1001/archinternmed.2010.94] [PMID: 20458083]
[http://dx.doi.org/10.1007/s00198-015-3365-x] [PMID: 26462494]
[http://dx.doi.org/10.1007/s00198-015-3403-8] [PMID: 26556735]
[http://dx.doi.org/10.1007/s11894-010-0141-0] [PMID: 20882439]
[http://dx.doi.org/10.11005/jbm.2018.25.3.141] [PMID: 30237993]
[http://dx.doi.org/10.1089/thy.2005.15.899] [PMID: 16131332]
[http://dx.doi.org/10.1016/j.dsx.2009.07.004]
[PMID: 19058589]
[http://dx.doi.org/10.1055/s-2001-18584] [PMID: 11460573]
[http://dx.doi.org/10.1089/thy.2011.0422] [PMID: 22663547]
[http://dx.doi.org/10.1089/thy.2010.0409] [PMID: 22136156]
[http://dx.doi.org/10.1046/j.1365-2362.1997.1380688.x] [PMID: 9229227]
[http://dx.doi.org/10.1042/bj2530087] [PMID: 3048254]
[http://dx.doi.org/10.1073/pnas.0805355106] [PMID: 19321430]
[http://dx.doi.org/10.1210/jc.2008-2235] [PMID: 19435829]
[http://dx.doi.org/10.2337/dc14-2515] [PMID: 26070591]
[http://dx.doi.org/10.1210/jc.2016-2255] [PMID: 27603906]
[http://dx.doi.org/10.1371/journal.pone.0125922] [PMID: 25938439]
[http://dx.doi.org/10.2337/db18-1975-P]
[http://dx.doi.org/10.1111/j.1742-1241.2010.02376.x] [PMID: 20642711]
[http://dx.doi.org/10.1111/j.1365-2265.2011.04029.x] [PMID: 21521298]
[http://dx.doi.org/10.4021/jocmr2010.03.281w] [PMID: 21811523]
[http://dx.doi.org/10.1371/journal.pone.0135233] [PMID: 26270348]
[http://dx.doi.org/10.1210/en.2015-1073] [PMID: 26218891]
[http://dx.doi.org/10.1186/1756-6614-5-14] [PMID: 23146624]
[http://dx.doi.org/10.1016/j.bone.2016.10.007] [PMID: 27742498]
[http://dx.doi.org/10.1210/en.2017-00794] [PMID: 29069393]
[http://dx.doi.org/10.1111/joim.12688] [PMID: 29034571]
[http://dx.doi.org/10.1007/s40618-017-0753-4] [PMID: 28853052]
[http://dx.doi.org/10.1001/archinte.162.3.338] [PMID: 11822927]
[http://dx.doi.org/10.1016/j.bone.2016.03.002] [PMID: 26946131]
[http://dx.doi.org/10.1001/jama.2015.5161] [PMID: 26010634]
[http://dx.doi.org/10.1016/j.bone.2014.10.009] [PMID: 25445448]
[http://dx.doi.org/10.1016/S0092-8674(03)00771-2] [PMID: 14567913]
[http://dx.doi.org/10.1172/JCI63948] [PMID: 22996689]
[http://dx.doi.org/10.1089/thy.2008.0158] [PMID: 18925834]
[http://dx.doi.org/10.1530/EJE-09-0139] [PMID: 19671706]
[http://dx.doi.org/10.11005/jbm.2019.26.1.45] [PMID: 30899724]
[PMID: 10686873]
[http://dx.doi.org/10.1210/me.2007-0033] [PMID: 17327419]
[http://dx.doi.org/10.1210/me.2007-0157] [PMID: 17488972]
[http://dx.doi.org/10.1038/366072a0] [PMID: 8232539]
[http://dx.doi.org/10.1182/blood-2006-07-037994] [PMID: 17202317]
[http://dx.doi.org/10.1073/pnas.0404888101] [PMID: 15531637]
[http://dx.doi.org/10.1172/JCI11066] [PMID: 11086024]
[http://dx.doi.org/10.1073/pnas.130200197] [PMID: 10869427]
[http://dx.doi.org/10.1002/jbmr.1500] [PMID: 22271394]
[http://dx.doi.org/10.1073/pnas.1013492108] [PMID: 21187391]
[http://dx.doi.org/10.1016/j.cmet.2008.07.001] [PMID: 18680714]
[http://dx.doi.org/10.1371/journal.pone.0012290] [PMID: 20808842]
[http://dx.doi.org/10.1073/pnas.1120735109] [PMID: 22393015]
[http://dx.doi.org/10.1016/j.cmet.2009.07.010] [PMID: 19723499]
[http://dx.doi.org/10.1002/jbmr.2394] [PMID: 25359628]
[http://dx.doi.org/10.1371/journal.pone.0044552] [PMID: 22970248]
[http://dx.doi.org/10.1002/jcb.24165] [PMID: 22511335]
[http://dx.doi.org/10.1007/s00198-013-2548-6] [PMID: 24337660]
[http://dx.doi.org/10.3109/09513590.2014.975683] [PMID: 25384921]
[http://dx.doi.org/10.1016/j.cmet.2015.09.012] [PMID: 26456334]
[http://dx.doi.org/10.1016/j.diabres.2012.03.005] [PMID: 22483749]
[http://dx.doi.org/10.1002/jbmr.321] [PMID: 21433069]
[http://dx.doi.org/10.1007/s00198-011-1679-x] [PMID: 21656264]
[http://dx.doi.org/10.1016/j.bone.2010.12.020] [PMID: 21185419]
[http://dx.doi.org/10.1002/cbf.1668] [PMID: 20517899]
[http://dx.doi.org/10.1002/cbf.2801] [PMID: 22249904]
[http://dx.doi.org/10.1016/j.bone.2005.04.039] [PMID: 16027060]
[http://dx.doi.org/10.1002/jbm.a.34313] [PMID: 22825804]
[http://dx.doi.org/10.1210/jc.2013-3338] [PMID: 24423302]
[http://dx.doi.org/10.1007/s11596-013-1105-z] [PMID: 23592138]
[http://dx.doi.org/10.1016/j.bone.2008.02.006] [PMID: 18378205]
[http://dx.doi.org/10.1038/nm.3084] [PMID: 23396210]
[http://dx.doi.org/10.1007/s00223-015-0075-5] [PMID: 26498169]
[http://dx.doi.org/10.1016/j.cmet.2015.05.021] [PMID: 26094891]
[http://dx.doi.org/10.2337/db13-0887] [PMID: 24009262]
[http://dx.doi.org/10.1007/s00198-015-3422-5] [PMID: 26588909]
[http://dx.doi.org/10.1016/S1473-3099(18)30413-4] [PMID: 30033232]
[http://dx.doi.org/10.1038/s41419-018-1136-2] [PMID: 30478280]
[http://dx.doi.org/10.1016/j.actbio.2018.10.027] [PMID: 30342282]
[http://dx.doi.org/10.1089/neu.2017.5414] [PMID: 29316847]
[http://dx.doi.org/10.1007/s10787-015-0239-y] [PMID: 26246395]
[PMID: 2058666]
[http://dx.doi.org/10.1016/0168-8227(90)90056-Y] [PMID: 2146103]
[http://dx.doi.org/10.7326/0003-4819-112-9-678] [PMID: 2110430]
[http://dx.doi.org/10.1016/S0168-8227(01)00325-4] [PMID: 11850097]
[http://dx.doi.org/10.1186/ar3868] [PMID: 22676348]
[http://dx.doi.org/10.5603/DK.2017.0034]
[http://dx.doi.org/10.1001/jama.298.2.187] [PMID: 17622600]
[PMID: 9918262]
[http://dx.doi.org/10.1002/art.27703] [PMID: 20722019]
[http://dx.doi.org/10.1016/j.bbrc.2013.05.047] [PMID: 23702482]
[http://dx.doi.org/10.1172/JCI66947] [PMID: 24316970]
[http://dx.doi.org/10.2492/inflammregen.32.222]
[http://dx.doi.org/10.1590/1806-9282.63.02.173] [PMID: 28355379]
[http://dx.doi.org/10.1007/s00296-011-2341-9] [PMID: 22238026]
[http://dx.doi.org/10.1007/s00018-018-2776-1] [PMID: 29427075]
[http://dx.doi.org/10.2174/1389450119666180626120852] [PMID: 29943700]
[http://dx.doi.org/10.1002/jcp.27335] [PMID: 30417506]
[http://dx.doi.org/10.1097/01.hjh.0000501260.52383.7b]
[http://dx.doi.org/10.1038/sj.bjp.0703638] [PMID: 11030725]
[http://dx.doi.org/10.1016/j.mce.2017.11.024] [PMID: 29208420]
[http://dx.doi.org/10.1016/j.bone.2018.06.002] [PMID: 29879544]
[http://dx.doi.org/10.1007/s00125-011-2216-3] [PMID: 21674177]
[http://dx.doi.org/10.1210/jc.2010-0305] [PMID: 20534760]
[http://dx.doi.org/10.1124/jpet.117.241281] [PMID: 28438778]
[http://dx.doi.org/10.1016/j.ejphar.2015.05.051] [PMID: 26027795]
[http://dx.doi.org/10.1002/oby.21563] [PMID: 27296301]
[http://dx.doi.org/10.1055/s-0031-1298027] [PMID: 22198815]
[http://dx.doi.org/10.1016/j.ejphar.2014.05.016] [PMID: 24858364]
[PMID: 25410076]
[http://dx.doi.org/10.1002/jbmr.1602] [PMID: 22437792]
[http://dx.doi.org/10.1038/nrrheum.2017.35] [PMID: 28275261]
[http://dx.doi.org/10.1007/s12291-010-0074-2] [PMID: 22211018]
[http://dx.doi.org/10.22631/rr.2018.69997.1046]
[http://dx.doi.org/10.7860/JCDR/2015/14857.6318] [PMID: 26436008]
[http://dx.doi.org/10.1359/jbmr.081234] [PMID: 19063687]
[http://dx.doi.org/10.1210/jc.2008-1455] [PMID: 18984661]
[http://dx.doi.org/10.1016/j.cca.2008.07.001] [PMID: 18657532]
[http://dx.doi.org/10.1530/EJE-09-0585] [PMID: 19671707]
[http://dx.doi.org/10.1016/j.bone.2011.04.017] [PMID: 21550430]
[http://dx.doi.org/10.1002/dmrr.1045] [PMID: 19877133]
[http://dx.doi.org/10.3945/ajcn.2009.28151] [PMID: 19776145]
[http://dx.doi.org/10.1172/JCI39901] [PMID: 20038793]
[http://dx.doi.org/10.1007/s00198-015-3273-0] [PMID: 26259649]
[http://dx.doi.org/10.1016/j.bone.2017.11.020] [PMID: 29183784]
[http://dx.doi.org/10.1016/j.peptides.2009.01.020] [PMID: 19428775]
[http://dx.doi.org/10.1016/S0006-291X(02)00697-6] [PMID: 12150974]
[http://dx.doi.org/10.4103/2230-8210.105571] [PMID: 23565489]
[http://dx.doi.org/10.2337/diabetes.50.6.1440] [PMID: 11375346]
[http://dx.doi.org/10.1073/pnas.0909422107] [PMID: 20194735]
[http://dx.doi.org/10.2337/dc09-1237] [PMID: 19808925]
[http://dx.doi.org/10.1007/s00125-011-2155-z] [PMID: 21503740]
[http://dx.doi.org/10.1158/1078-0432.CCR-07-4879] [PMID: 18927274]
[http://dx.doi.org/10.1054/ghir.2002.0265] [PMID: 12175645]
[http://dx.doi.org/10.1007/s001250051623] [PMID: 11317665]
[http://dx.doi.org/10.1016/j.metabol.2011.05.014] [PMID: 21741060]
[http://dx.doi.org/10.1007/s00125-008-1016-x] [PMID: 18496669]
[http://dx.doi.org/10.2169/internalmedicine.56.7416] [PMID: 28154269]
[http://dx.doi.org/10.1007/s00198-018-4638-y] [PMID: 30030585]
[http://dx.doi.org/10.1016/j.archger.2014.08.011] [PMID: 25240725]
[http://dx.doi.org/10.4238/2015.July.13.10] [PMID: 26214445]
[http://dx.doi.org/10.1074/jbc.M208265200] [PMID: 12215457]
[http://dx.doi.org/10.1210/endo-124-1-301] [PMID: 2909370]
[http://dx.doi.org/10.1073/pnas.1502301112] [PMID: 25825734]
[http://dx.doi.org/10.1210/endo.131.3.1505451] [PMID: 1505451]
[http://dx.doi.org/10.1210/endo.136.1.7828521] [PMID: 7828521]
[http://dx.doi.org/10.3389/fphar.2017.00407] [PMID: 28713268]
[PMID: 30564859]
[http://dx.doi.org/10.1210/jc.2015-4180] [PMID: 26930183]
[http://dx.doi.org/10.1530/JOE-11-0015] [PMID: 21372151]
[http://dx.doi.org/10.1016/j.stemcr.2016.02.002] [PMID: 26947974]
[http://dx.doi.org/10.1210/endo.137.9.8756532] [PMID: 8756532]
[http://dx.doi.org/10.1210/en.2007-1292] [PMID: 18039776]
[http://dx.doi.org/10.1359/jbmr.090732] [PMID: 19594306]
[http://dx.doi.org/10.1016/j.ejphar.2006.02.030] [PMID: 16564524]
[http://dx.doi.org/10.1016/j.jdiacomp.2009.05.002] [PMID: 19628413]
[http://dx.doi.org/10.1002/jcb.23206] [PMID: 21618594]
[http://dx.doi.org/10.1007/s00774-019-00989-y] [PMID: 30706148]
[http://dx.doi.org/10.1185/03007990902801147] [PMID: 19292601]
[http://dx.doi.org/10.3109/13697137.2015.1103615]