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Review Article

Vaccinium myrtillus L. Fruits as a Novel Source of Phenolic Compounds with Health Benefits and Industrial Applications - A Review

Author(s): Tânia C. S. P. Pires , Cristina Caleja , Celestino Santos-Buelga , Lillian Barros* and Isabel C.F.R. Ferreira*

Volume 26, Issue 16, 2020

Page: [1917 - 1928] Pages: 12

DOI: 10.2174/1381612826666200317132507

Abstract

Consumers’ demand for healthier foods with functional properties has had a clear influence on the food industry and in this sense, they have been attaching natural sources of bioactive ingredients into food products. Vaccinium myrtillus L. (bilberry) is known to be a functional food, presenting its fruits in the form of a small dark blueberry. This coloration is due to its high content in anthocyanin, being also associated with bilberries’ beneficial health effects. In the bilberry industry, there is a very high annual loss of this fruit due to the less aesthetic shape or appearance, in which they cannot be considered suitable for sale and are therefore disposed of as biological waste. Therefore, it is of great importance to valorize this fruit and this review aimed to completely characterize the fruits of V. myrtillus in order to comprehend the relationship between their consumption and the beneficial effects regarding consumer’s health. Thus, this review provides a description of the nutritional and bioactive compounds present in bilberry fruits, followed by their beneficial health effects. An overview of the natural pigments present in these fruits was also explored, focusing particularly in the anthocyanins composition, which represents the most widely studied class of bioactive compounds of V. myrtillus fruits. Finally, industrial applications of these fruits and by-products, as an efficient approach to the production of value-added products with economical and environmental impact, were also discussed.

In general, V. myrtillus is a rich source of micronutrients and phytochemical compounds, such as organic acids, sugars, vitamins, fibers and phenolic compounds (anthocyanin and non-anthocyanin compounds), with nutritional and functional properties, that justify the growing interest in these berries, not only for food applications, but also in the pharmaceutical industry.

Keywords: Vaccinium myrtillus L., phenolic compounds, natural pigments, health benefits, anthocyanin, vitamins.

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[1]
Nagulsamy P, Ponnusamy R, Thangaraj P. Evaluation of antioxidant, anti-inflammatory, and antiulcer properties of Vaccinium leschenaultii Wight: A therapeutic supplement. J Food Drug Anal 2015; 23: 376-86.
[2]
Zorenc Z, Veberic R, Mikulic-Petkovsek M. Are processed bilberry products a good source of phenolics. J Food Sci 2018; 83(7): 1856-61.
[3]
Zoratti L, Klemettilä H, Jaakola L. Bilberry (Vaccinium myrtillus L). Ecotypes Nutr Compos Fruit Cultiv 2016; pp. 83-99.
[4]
Colak N, Primetta AK, Riihinen KR, et al. Phenolic compounds and antioxidant capacity in different-colored and non-pigmented berries of bilberry (Vaccinium myrtillus L.). Food Biosci 2017; 20: 67-78.
[5]
Abreu OA, Barreto G, Prieto S. Vaccinium (ericaceae): Ethnobotany and pharmacological potentials. Emir J Food Agric 2014; 26: 577-91.
[6]
Crespo MC, Visioli F. A brief review of blue- and bilberries’ potential to curb cardio-metabolic perturbations: focus on diabetes. Curr Pharm Des 2017; 23(7): 983-8.
[http://dx.doi.org/10.2174/1381612822666161010120523] [PMID: 27748191]
[7]
Li R, Wang P. Guo Q qi, Wang Z yu. Anthocyanin composition and content of the Vaccinium uliginosum berry. Food Chem 2011; 125: 116-20.
[8]
Primetta AK, Jaakola L, Ayaz FA, Inceer H, Riihinen KR. Anthocyanin fingerprinting for authenticity studies of bilberry (Vaccinium myrtillus L.). Food Control 2013; 30: 662-7.
[9]
Colak N, Torun H, Gruz J. Strnad M, Hermosín-Gutiérrez I,Hayirlioglu-Ayaz S, et al. Bog bilberry phenolics, antioxidant capacity and nutrient profile. J Food Chem 2016; 201: 339-49.
[http://dx.doi.org/10.1016/j.foodchem.2016.01.062]
[10]
Murley T, Chambers E. The influence of colorants, flavorants and product identity on perceptions of naturalness. Foods 2019; 8(8)
[http://dx.doi.org/10.3390/foods8080317]
[11]
Karam MC, Petit J, Zimmer D, Baudelaire Djantou E, Scher J. Effects of drying and grinding in production of fruit and vegetable powders. A review. J Food Eng 2016; 188: 32-49.
[12]
Nin S, Petrucci WA, Del Bubba M, Ancillotti C, Giordani E. Effects of environmental factors on seed germination and seedling establishment in bilberry (Vaccinium myrtillus L.). Scientia Horticulturae 2017; 226: 241-9.
[13]
Može Š, Polak T, Gašperlin L, et al. Phenolics in Slovenian bilberries ( Vaccinium myrtillus L.) and blueberries ( Vaccinium corymbosum L.). J Agric Food Chem 2011; 59: 6998-7004.
[14]
Chu WK, Cheung SC, Lau RA, Benzie IF. Herbal medicine -biomolecular and clinical aspectsHerb Med -biomolecular Clin Asp second. Group T& F. 2011; pp. 55-67.
[15]
Coudun C, Gégout J. Quantitative prediction of the distribution and abundance of Vaccinium myrtillus with climatic and edaphic factors. J Veg Sci 2007; 18(4): 517-24.
[16]
Barizza E, Guzzo F, Fanton P, et al.Nutritional profile and productivity of bilberry (Vaccinium myrtillus L.) in different habitats of a protected area of the eastern Italian Alps. J Food Sci 2013; 78(5): C673-8.
[17]
Akerström Å, Jaakola L, Bång U, Jäderlund A. Effects of latitude-related factors and geographical origin on anthocyanidin concentrations in fruits of Vaccinium myrtillus L. (bilberries). J Agric Food Chem 2010; 58(22): 11939-45.
[18]
Lätti AK, Jaakola L, Riihinen KR, Kainulainen PS. Anthocyanin and flavonol variation in bog bilberries (Vaccinium uliginosum L.) in Finland. Agric Food Chem 2010; 58(1): 427-33.
[19]
Upton R. Bilberry Fruit Vaccinium myrtillus. L. Standards of Analysis, Quality Control, and Therapeutics 2001.
[20]
Ferlemi AV, Lamari FN. Berry leaves: An alternative source of bioactive natural products of nutritional and medicinal value. Antioxidants(Basel) 2016; 5
[21]
Uleberg E, Rohloff J, Jaakola L, et al. Effects of temperature and photoperiod on yield and chemical composition of northern and southern clones of bilberry (Vaccinium myrtillus L.). J Agric Food Chem 2012; 60: 10406-14.
[22]
Zorenc Z, Veberic R, Stampar F, Koron D, Mikulic-Petkovsek M. White versus blue: Does the wild ‘albino’ bilberry (Vaccinium myrtillus L.) differ in fruit quality compared to the blue one? Food Chem 2016; 211: 876-82.
[23]
Mikulic-Petkovsek M, Schmitzer V, Slatnar A, Stampar F, Veberic R. A comparison of fruit quality parameters of wild bilberry (Vaccinium myrtillus L.) growing at different locations. J Sci Food Agric 2015; 95: 776-85.
[24]
Cocetta G, Karppinen K, Suokas M, et al. Ascorbic acid metabolism during bilberry (Vaccinium myrtillus L.) fruit development. J Plant Physiol 2012; 169: 1059-65.
[25]
Aura AM, Holopainen-Mantila U, Sibakov J, Kössö T, Mokkila M, Kaisa P. Bilberry and bilberry press cake as sources of dietary fibre. Food Nutr Res 2015; 59
[http://dx.doi.org/10.3402/fnr.v59.28367]
[26]
Mikulic-Petkovsek M, Schmitzer V, Slatnar A, Stampar F, Veberic R. Composition of sugars, organic acids, and total phenolics in 25 wild or cultivated berry species. J Food Sci 2012; 77: 1064-71.
[27]
Silva BM, Andrade PB, Mendes GC, Seabra RM, Ferreira MA. Study of the organic acids composition of quince (Cydonia oblonga Miller) fruit and jam. J Agric Food Chem 2002; 50: 2313-7.
[28]
Giné Bordonaba J, Terry LA. Manipulating the taste-related composition of strawberry fruits (Fragaria× ananassa) from different cultivars using deficit irrigation. Food Chem 2010; 122(4): 1020-6.
[29]
Michalska A, Łysiak G. Bioactive compounds of blueberries: Post-harvest factors influencing the nutritional value of products. Int J Mol Sci 2015; 16: 18642-63.
[30]
Damascos MA, Arribere M, Svriz M, Bran D. Fruit mineral contents of six wild species of the North Andean Patagonia, Argentina. Biol Trace Elem Res 2008; 125(1): 72-80.
[http://dx.doi.org/10.1007/s12011-008-8159-y]
[31]
Desideri D, Meli MA, Roselli C. Determination of essential and non-essential elements in some medicinal plants by polarised X ray fluorescence spectrometer (EDPXRF). Microchem J 2010; 95(2): 174-80.
[32]
Kabata-Pendias A. Trace elements in soils and plants. 4th ed. 2010.
[http://dx.doi.org/10.1201/b10158]
[33]
Fidaleo M, Lavecchia R, Maffei G, Zuorro A. Phenolic extracts from bilberry (Vaccinium myrtillus L.) residues as new functional food ingredients. Int J App Eng Research 2015; 10(16): 37125-8.
[34]
Ambriz-Pérez DL, Leyva-López N, Gutierrez-Grijalva EP, Heredia JB. Phenolic compounds: Natural alternative in inflammation treatment A review. Congesnt Food Agric 2016; p. 2.
[35]
Rodrigo R, Gil D, Miranda-Merchak A, Kalantzidis G. Antihypertensive role of polyphenols. Adv Clin Chem 2012; 58: 225-54.
[http://dx.doi.org/10.1016/B978-0-12-394383-5.00014-X] [PMID: 22950347]
[36]
Bouarab-Chibane L, Forquet V, Lantéri P, et al. Antibacterial properties of polyphenols: Characterization and QSAR (Quantitative structure-activity relationship) models. Front Microbiol 2019. 10: 1-23.
[37]
Anantharaju PG, Gowda PC, Vimalambike MG, Madhunapantula SV. An overview on the role of dietary phenolics for the treatment of cancers. Nutr J 2016. 15: 1-16.
[http://dx.doi.org/10.1186/s12937-016-0217-2]
[38]
Tian Y, Liimatainen J, Alanne A-L, et al. Phenolic compounds extracted by acidic aqueous ethanol from berries and leaves of different berry plants. Food Chem 2017; 220: 266-81.
[http://dx.doi.org/10.1016/j.foodchem.2016.09.145]
[39]
Rue EA, Rush MD, van Breemen RB. Procyanidins: a comprehensive review encompassing structure elucidation via mass spectrometry. Phytochem Rev 2018; 17(1): 1-16.
[http://dx.doi.org/10.1007/s11101-017-9507-3]
[40]
Ge YW, Zhu S, Kazuma K, Wei SL, Yoshimatsu K, Komatsu K. Molecular ion index assisted comprehensive profiling of B-type oligomeric proanthocyanidins in rhubarb by high performance liquid chromatography-tandem mass spectrometry. Anal Bioanal Chem 2016; 408(13): 3555-70.
[http://dx.doi.org/10.1007/s00216-016-9433-z]
[41]
Abo K a, Fred-Jaiyesimi a a, Jaiyesimi a E a, et al. Phenolic acids in foods. An overview of analytical methodology phenolic acids in foods : an overview of analytical methodology. J Agric Food Chem 2013; 115: 137-89.
[42]
Deǧirmencioǧlu N, Gürbüz O, Karatepe GE, Irkin R. Influence of hot air drying on phenolic compounds and antioxidant capacity of blueberry (Vaccinium myrtillus) fruit and leaf. J Appl Bot Food Qual 2017; 90: 115-25.
[43]
Tumbas Šaponjac V, Čanadanović-Brunet J, Ćetković G, Djilas S, Četojević-Simin D. Dried bilberry (Vaccinium myrtillus L.) extract fractions as antioxidants and cancer cell growth inhibitors. LWT Food Sci Tech 2015; 61: 615-21.
[44]
Ehala S, Vaher M, Kaljurand M. Characterization of phenolic profiles of Northern European berries by capillary electrophoresis and determination of their antioxidant activity. J Agric Food Chem 2005; 53(16): 6484-90.
[http://dx.doi.org/10.1021/jf050397w]
[45]
Silva S, Costa EM, Calhau C, Morais RM, Pintado ME. Anthocyanin extraction from plant tissues: A review. Crit Rev Food Sci Nutr 2017; 57(14): 3072-83.
[http://dx.doi.org/10.1080/10408398.2015.1087963] [PMID: 26529399]
[46]
Ancillotti C, Ciofi L, Pucci D, et al. Polyphenolic profiles and antioxidant and antiradical activity of Italian berries from Vaccinium myrtillus L. and Vaccinium uliginosum L. subsp. gaultherioides (Bigelow) S.B. Young. Food Chem 2016; 204: 176-84.
[http://dx.doi.org/10.1016/j.foodchem.2016.02.106] [PMID: 26988491]
[47]
Lu Y, Wang L, Xue Y, et al. Production of violet pigment by a newly isolated psychrotrophic bacterium from a glacier in Xinjiang, China. Biochem Eng J 2009; 43: 135-41.
[48]
Parmar RS, Singh C. A comprehensive study of eco-friendly natural pigment and its applications. Biochem Biophys Rep 2018;; 13: 22-6.
[http://dx.doi.org/10.1016/j.bbrep.2017.11.002]
[49]
Mapari SAS, Thrane U, Meyer AS. Fungal polyketide azaphilone pigments as future natural food colorants? Trends Biotechnol 2010; 28(6): 300-7.
[http://dx.doi.org/10.1016/j.tibtech.2010.03.004]
[50]
Carocho M, Barreiro MF, Morales P, Ferreira ICFR. Adding molecules to food, pros and cons: A review on synthetic and natural food additives. Compr Rev Food Sci Food Saf 2014; 13: 377-99.
[http://dx.doi.org/10.1111/1541-4337.12065]
[51]
Loypimai P, Moongngarm A, Chottanom P, Moontree T. Ohmic heating-assisted extraction of anthocyanins from black rice bran to prepare a natural food colourant. Innov Food Sci Emerg Technol 2015; 27: 102-10.
[http://dx.doi.org/10.1016/j.ifset.2014.12.009]
[52]
Khoo HE, Azlan A, Tang ST, Lim SM. Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits. Food Nutr Res 2017; 61 1361779
[http://dx.doi.org/10.1080/16546628.2017.1361779]
[53]
Prior RLE, E Wilkes S, R Rogers T, Khanal RC, Wu X, Howard LR. Purified blueberry anthocyanins and blueberry juice alter development of obesity in mice fed an obesogenic high-fat diet. J Agric Food Chem 2010; 58: 3970-6.
[http://dx.doi.org/10.1021/jf902852d]
[54]
Fernandes I, Marques C, Évora A, Faria A, Mateus N, De Freitas V. Anthocyanins : nutrition and health bioact mol foods Nature Switzerland. Springer 2019; pp. 1097-133.
[55]
Yamaura K, Ishiwatari M, Yamamoto M, Shimada M, Bi Y, Ueno K. Anthocyanins, but not anthocyanidins, from bilberry (Vaccinium myrtillus L.) alleviate pruritus via inhibition of mast cell degranulation. J Food Sci 2012; 77(12): H262-7.
[56]
Cooke D, Schwarz M, Boocock D, et al. Effect of cyanidin-3-glucoside and an anthocyanin mixture from bilberry on adenoma development in the ApcMin mouse model of intestinal carcinogenesis--relationship with tissue anthocyanin levels. Int J Cancer 2006; 119: 2213-20.
[57]
Camire ME, Chaovanalikit A, Dougherty MP, Briggs J. Blueberry and grape anthocyanins as breakfast cereal colorants. J Food Sci 2002; 67(1): 438-41.
[http://dx.doi.org/10.1111/j.1365-2621.2002.tb11425.x]
[58]
Pasqualone A, Bianco AM, Paradiso VM. Production trials to improve the nutritional quality of biscuits and to enrich them with natural anthocyanins. CYTA J Food 2013; 11: 301-8.
[http://dx.doi.org/10.1080/19476337.2012.753113]
[59]
Eekaya Kotan T. Mineral composition and some quality characteristics of ice creams manufactured with the addition of Blueberry. J Food 2018; 43: 635-43.
[http://dx.doi.org/10.15237/gida.GD18042]
[60]
de Mello VDF, Lankinen MA, Lindström J, et al. Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes. Mol Nutr Food Res 2017; 61(9)
[61]
Karcheva-Bahchevanska DP, Lukova PK, Nikolova MM, Mladenov RD, Iliev IN. Effect of extracts of bilberries (Vaccinium myrtillus L.) on amyloglucosidase and α-glucosidase activity. Folia Med (Plovdiv) 2017; 59(2): 197-202.
[62]
Schink A, Neumann J, Leifke AL, et al. Screening of herbal extracts for TLR2- and TLR4-dependent anti-inflammatory effects. PLoS One 2018; 13(10) e0203907
[http://dx.doi.org/10.1371/journal.pone.0203907]
[63]
Prokop J, Lněničková K, Cibiček N, et al. Effect of bilberry extract (Vaccinium myrtillus L.) on drug-metabolizing enzymes in rats. Food Chem Toxicol 2019; 129: 382-90.
[64]
Prakash C, Zuniga B, Song CS, et al. Nuclear receptors in drug metabolism, drug response and drug interactions. Nucl Receptor Res 2015; 2: 1-20.
[http://dx.doi.org/10.11131/2015/101178] [PMID: 27478824]
[65]
Lima GPP, Vianello F, Corrêa CR. Polyphenols in fruits and vegetables and its effect on human health. Food Nutr Sci 2014; 5: 1065-82.
[66]
Tumbas V, Čanadanović-Brunet J, Gille L, Dilas S, Ćetković G. Superoxide anion radical scavenging activity of bilberry (Vaccinium myrtillus L.). J Berry Res 2010; 1(1): 13-23.
[67]
Dróżdż P, Šėžienė V, Pyrzynska K. phytochemical properties and antioxidant activities of extracts from wild blueberries and lingonberries. Plant Foods Hum Nutr 2017; 72(4): 360-4.
[68]
Veljković M, Pavlović DR, Stojiljković N, et al. Bilberry: chemical profiling, in vitro and in vivo antioxidant activity and nephroprotective effect against gentamicin toxicity in rats. Phytother Res 2017; 31(1): 115-23.
[69]
Kowalska K, Olejnik A, Szwajgier D, Olkowicz M. Inhibitory activity of chokeberry, bilberry, raspberry and cranberry polyphenol-rich extract towards adipogenesis and oxidative stress in differentiated 3T3-L1 adipose cells. PLoS One 2017; 12(11)
[70]
Kowalska K, Olejnik A, Rychlik J, Grajek W. Cranberries (Oxycoccus quadripetalus) inhibit lipid metabolism and modulate leptin and adiponectin secretion in 3T3-L1 adipocytes 2015. Food Chem;185: 383-8.
[71]
Suzuki R, Tanaka M, Takanashi M, Hussain A, Yuan B, Toyoda H. et al. Anthocyanidins-enriched bilberry extracts inhibit 3T3-L1 adipocyte differentiation via the insulin pathway 2011; 8(14)
[72]
Demirel Sezer ED, Oktay LM, Karadadaş E, Memmedov H, Selvi Gunel N, Sözmen E. Assessing Anticancer Potential of Blueberry Flavonoids, Quercetin, Kaempferol, and Gentisic Acid, Through Oxidative Stress and Apoptosis Parameters on HCT-116 Cells. J Med Food 2019; 22(11): 1118-6.
[73]
Thibado SP, Thornthwaite JT, Ballard TK, Goodman BT. Anticancer effects of Bilberry anthocyanins compared with NutraNanoSphere encapsulated Bilberry anthocyanins. Mol Clin Oncol 2017; 8(2): 330-5.
[http://dx.doi.org/10.3892/mco.2017.1520]
[74]
Nguyen V, Tang J, Oroudjev E, et al. Cytotoxic effects of bilberry extract on MCF7-GFP-tubulin breast cancer cells. J Med Food 2010; 13(2): 278-85.
[http://dx.doi.org/10.1089/jmf.2009.0053]
[75]
Brader L, Overgaard A, Christensen LP, Jeppesen PB, Hermansen K. Polyphenol-rich bilberry ameliorates total cholesterol and LDL-cholesterol when implemented in the diet of Zucker diabetic fatty rats. Rev Diabet Stud 2013; 10(4): 270-82.
[http://dx.doi.org/10.1900/RDS.2013.10.270]
[76]
Ashour OM, Elberry AA, Alahdal A, et al. Protective effect of bilberry (Vaccinium myrtillus) against doxorubicin-induced oxidative cardiotoxicity in rats. Med Sci Monit 2011; 17(4): BR110-5.
[77]
Erlund I, Koli R, Alfthan G, et al. Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol. Am J Clin Nutr 2008; 87(2): 323-31.
[http://dx.doi.org/10.1093/ajcn/87.2.323]
[78]
Žiberna L, Lunder M, Može Š, Vanzo A, Drevenšek G. Cardioprotective effects of bilberry extract on ischemia-reperfusion-induced injury in isolated rat heart. BMC Pharmacol 2009; 9
[http://dx.doi.org/10.1186/1471-2210-9-S2-A55]
[79]
Luo H, Lv XD, Wang GE, Li YF, Kurihara H, He RR. Anti-inflammatory effects of anthocyanins-rich extract from bilberry (Vaccinium myrtillus L.) on croton oil-induced ear edema and Propionibacterium acnes plus LPS-induced liver damage in mice. Int J Food Sci 2014; 65(5): 594-601.
[80]
Kolehmainen M, Mykkänen O, Kirjavainen PV, et al. Bilberries reduce low-grade inflammation in individuals with features of metabolic syndrome. Mol Nutr Food Res 2012; 56(10): 1501-10.
[http://dx.doi.org/10.1002/mnfr.201200195]
[81]
Granfeldt YE, Björck IME. A bilberry drink with fermented oatmeal decreases postprandial insulin demand in young healthy adults. Nutr J 2011; 10(57): 333-53.
[http://dx.doi.org/10.1186/1475-2891-10-57]
[82]
Ceriello A, Genovese S. Atherogenicity of postprandial hyperglycemia and lipotoxicity. Rev Endocr Metab Disord 2016; 17: 111-6.
[http://dx.doi.org/10.1007/s11154-016-9341-8]
[83]
Xu J, Jönsson T, Plaza M, et al. Probiotic fruit beverages with different polyphenol profiles attenuated early insulin response. Nutr J 2018; 17(1): 34.
[http://dx.doi.org/10.1186/s12937-018-0335-0]
[84]
McDougall GJ, Stewart D. The inhibitory effects of berry polyphenols on digestive enzymes. Biofactors 2005; 23(4): 189-95.
[http://dx.doi.org/10.1002/biof.5520230403]
[85]
Xiao T, Guo Z, Sun B, Zhao Y. Identification of anthocyanins from four kinds of berries and their inhibition activity to α-glycosidase and protein tyrosine phosphatase 1B by HPLC-FT-ICR MS/MS. J Agric Food Chem 2017; 65(30): 6211-21.
[86]
de Sales PM, de Souza PM, Simeoni LA. Magalhães P de O, Silveira D. α-amylase inhibitors: A review of raw material and isolated compounds from plant source. J Pharm Pharm Sci 2012; 15(1): 141-83.
[87]
Ozawa Y, Kawashima M, Inoue S, et al. Bilberry extract supplementation for preventing eye fatigue in video display terminal workers. J Nutr Health Aging 2015; 19(5): 548-54.
[http://dx.doi.org/10.1007/s12603-014-0573-6]
[88]
Riva A, Togni S, Franceschi F, et al. The effect of a natural, standardized bilberry extract (Mirtoselect®) in dry eye: a randomized, double blinded, placebo-controlled trial. Eur Rev Med Pharmacol Sci 2017; 21(10): 2518-25.
[89]
Canter PH, Ernst E. Anthocyanosides of Vaccinium myrtillus (bilberry) for night vision--a systematic review of placebo-controlled trials. Surv Ophthalmol 2004; 49(1): 38-50.
[90]
Head KA. Natural therapies for ocular disorders part two: Cataracts and glaucoma. Rev. 6th ed.. Altern. Med 2001; pp. 141-66.
[91]
Puupponen-Pimiä R, Nohynek L, Ammann S, Oksman-Caldentey KM, Buchert J. Enzyme-assisted processing increases antimicrobial and antioxidant activity of bilberry. J Agric Food Chem 2008; 56(3): 681-8.
[http://dx.doi.org/10.1021/jf072001h]
[92]
Toivanen M, Huttunen S, Lapinjoki S, Tikkanen-Kaukanen C. Inhibition of adhesion of Neisseria meningitidis to human epithelial cells by berry juice polyphenolic fractions. Phytother Res 2011; 25(6): 828-32.
[http://dx.doi.org/10.1002/ptr.3349]
[93]
Huttunen S, Toivanen M, Arkko S, Ruponen M, Tikkanen-Kaukanen C. Inhibition activity of wild berry juice fractions against Streptococcus pneumoniae binding to human bronchial cells. Phytother Res 2011; 25(1): 122-7.
[94]
Trivedi P, Karppinen K, Klavins L, et al. Compositional and morphological analyses of wax in northern wild berry species. Food Chem 2019; 295: 441-8.
[http://dx.doi.org/10.1016/j.foodchem.2019.05.134]
[95]
Benvenuti S, Brighenti V, Pellati F. High-performance liquid chromatography for the analytical characterization of anthocyanins in Vaccinium myrtillus L. (bilberry) fruit and food products. Anal Bioanal Chem 2018; 410: 3559-71.
[96]
Zhou L, Lie Y, Briers H, Fan J, et al. natural product recovery from bilberry (Vaccinium myrtillus l.) presscake via microwave hydrolysis. ACS Sustain Chem& Eng 2018; 6(3): 3676-85.
[97]
Oliveira G, Eliasson L, Ehrnell M, Höglund E, Andlid T, Alminger M. Tailoring bilberry powder functionality through processing: Effects of drying and fractionation on the stability of total polyphenols and anthocyanins. Food Sci Nutr 2019; 7(3)
[98]
Bobinaitė R, Pataro G, Lamanauskas N, Šatkauskas S, Viškelis P, Ferrari G. Application of pulsed electric field in the production of juice and extraction of bioactive compounds from blueberry fruits and their by-products. J Food Sci Technol 2015; 52(9): 5898-905.
[http://dx.doi.org/10.1007/s13197-014-1668-0]
[99]
Pataro G, Bobinaitė R, Bobinas Č, et al. Improving the Extraction of Juice and Anthocyanins from Blueberry Fruits and Their By-products by Application of Pulsed Electric Fields. Food Bioprocess Technol 2017; 10(9): 1595-605.
[100]
Stanoeva JP, Stefova M, Andonovska KB, Vankova A, Stafilov T. Phenolics and mineral content in bilberry and bog bilberry from Macedonia. Int J Food Prop 2017; 20: S863-83.
[http://dx.doi.org/10.1080/10942912.2017.1315592]
[101]
Kähkönen MP, Heinämäki J, Ollilainen V, Heinonen M. Berry anthocyanins: Isolation, identification and antioxidant activities. J Sci Food Agric 2003; 83: 1403-11.
[102]
Laaksonen O, Sandell M, Kallio H. Chemical factors contributing to orosensory profiles of bilberry (Vaccinium myrtillus) fractions. Eur Food Res Technol 2010; 231(2): 271-85.
[103]
Dincheva Ivayla, Badjakov Ilian. Assesment of the anthocyanin variation in bulgarian bilberry (Vaccinium Myrtillus L.) and lingonberry (Vaccinium Vitis-Idaea L.). Int J Med Pharm Sci 2016; 6: 39-49.
[104]
Müller D, Schantz M, Richling E. High performance liquid chromatography analysis of anthocyanins in bilberries (Vaccinium myrtillus L.), blueberries (Vaccinium corymbosum L.), and corresponding juices. J Food Sci 2012; 77(4): C340-5.

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