Login Register Cart 0
Generic placeholder image

Current Alzheimer Research

Editor-in-Chief

ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe Translate in Chinese
Research Article

Tactile Angle Discrimination Decreases due to Subjective Cognitive Decline in Alzheimer’s Disease

Author(s): Zhilin Zhang, Guanqun Chen, Jian Zhang, Tianyi Yan, Ritsu Go , Hidenao Fukuyama, Jinglong Wu, Ying Han* and Chunlin Li*

Volume 17, Issue 2, 2020

Page: [168 - 176] Pages: 9

DOI: 10.2174/1567205017666200309104033

Price: $65

Abstract

Background: Subjective Cognitive Decline (SCD) is the early preclinical stage of Alzheimer's Disease (AD). Previous study provided an invaluable contribution by showing that a tactile angle discrimination system can be used to distinguish between healthy older individuals and patients with mild cognitive impairment and AD. However, that study paid little attention to the relationship between tactile angle discrimination and SCD. Therefore, a means of differentiating Normal Controls (NCs), elderly subjects with SCD, patients with amnestic Mild Cognitive Impairment (aMCI), and AD is urgently needed.

Methods: In the present study, we developed a novel tactile discrimination device that uses angle stimulation applied to the index finger pad to identify very small differences in angle discrimination between the NC (n = 30), SCD (n = 30), aMCI (n = 30), and AD (n = 30) groups. Using a three-alternative forced-choice and staircase method, we analyzed the average accuracy and threshold of angle discrimination.

Results: We found that accuracy significantly decreased while thresholds of angle discrimination increased in the groups in the following order: NC, SCD, aMCI, and AD. The area under the receiver operating characteristic curve also indicated that the tactile angle discrimination threshold was better than Mini-Mental State Examination scores in distinguishing NC individuals and SCD patients.

Conclusion: These findings emphasize the importance of tactile working memory dysfunction in explaining the cognitive decline in angle discrimination that occurs in SCD to AD patients and offer further insight into the very early detection of subjects with AD.

Keywords: Alzheimer`s disease, subjective cognitive decline, cognitive function, tactile, angle discrimination, working memory.

« Previous Next »
[1]
Vellas B, Aisen PS, Sampaio C, et al. Prevention trials in Alzheimer’s disease: an EU-US task force report. Prog Neurobiol 95(4): 594-600. (2011).
[http://dx.doi.org/10.1016/j.pneurobio.2011.08.014] [PMID: 21925234]
[2]
Ewers M, Sperling RA, Klunk WE, Weiner MW, Hampel H. Neuroimaging markers for the prediction and early diagnosis of Alzheimer’s disease dementia. Trends Neurosci 34(8): 430-42. (2011).
[http://dx.doi.org/10.1016/j.tins.2011.05.005] [PMID: 21696834]
[3]
Jessen F, Amariglio RE, van Boxtel M, et al. A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer’s disease. Alzheimers Dement 10(6): 844-52. (2014).
[http://dx.doi.org/10.1016/j.jalz.2014.01.001] [PMID: 24798886]
[4]
Rönnlund M, Sundström A, Adolfsson R, Nilsson LG. Self-reported memory failures: associations with future dementia in a population-based study with long-term follow-up. J Am Geriatr Soc 63(9): 1766-73. (2015).
[http://dx.doi.org/10.1111/jgs.13611] [PMID: 26280989]
[5]
Mitchell AJ, Beaumont H, Ferguson D, Yadegarfar M, Stubbs B. Risk of dementia and mild cognitive impairment in older people with subjective memory complaints: meta-analysis. Acta Psychiatr Scand 130(6): 439-51. (2014).
[http://dx.doi.org/10.1111/acps.12336] [PMID: 25219393]
[6]
Buckley RF, Maruff P, Ames D, et al. Subjective memory decline predicts greater rates of clinical progression in preclinical Alzheimer’s disease. Alzheimers Dement 12(7): 796-804. (2016).
[http://dx.doi.org/10.1016/j.jalz.2015.12.013] [PMID: 26852195]
[7]
Wang Y, West JD, Flashman LA, et al. Selective changes in white matter integrity in MCI and older adults with cognitive complaints. Biochim Biophys Acta 1822(3): 423-30. (2012).
[http://dx.doi.org/10.1016/j.bbadis.2011.08.002] [PMID: 21867750]
[8]
Thomann PA, Seidl U, Brinkmann J, et al. Hippocampal morphology and autobiographic memory in mild cognitive impairment and Alzheimer’s disease. Curr Alzheimer Res 9(4): 507-15. (2012).
[http://dx.doi.org/10.2174/156720512800492558] [PMID: 22372439]
[9]
Amariglio RE, Becker JA, Carmasin J, et al. Subjective cognitive complaints and amyloid burden in cognitively normal older individuals. Neuropsychologia 50(12): 2880-6. (2012).
[http://dx.doi.org/10.1016/j.neuropsychologia.2012.08.011] [PMID: 22940426]
[10]
Hafkemeijer A, Altmann-Schneider I, Oleksik AM, et al. Increased functional connectivity and brain atrophy in elderly with subjective memory complaints. Brain Connect 3(4): 353-62. (2013).
[http://dx.doi.org/10.1089/brain.2013.0144] [PMID: 23627661]
[11]
Scheef L, Spottke A, Daerr M, et al. Glucose metabolism, gray matter structure, and memory decline in subjective memory impairment. Neurology 79(13): 1332-9. (2012).
[http://dx.doi.org/10.1212/WNL.0b013e31826c1a8d] [PMID: 22914828]
[12]
Lederman SJ, Klatzky RL. Haptic perception: a tutorial. Atten Percept Psychophys 71(7): 1439-59. (2009).
[http://dx.doi.org/10.3758/APP.71.7.1439] [PMID: 19801605]
[13]
Shaffer SW, Harrison AL. Aging of the somatosensory system: a translational perspective. Phys Ther 87(2): 193-207. (2007).
[http://dx.doi.org/10.2522/ptj.20060083] [PMID: 17244695]
[14]
Vega-Bermudez F, Johnson KO. Spatial acuity after digit amputation. Brain 125(Pt 6): 1256-64. (2002).
[http://dx.doi.org/10.1093/brain/awf129] [PMID: 12023314]
[15]
Stevens JC, Choo KK. Spatial acuity of the body surface over the life span. Somatosens Mot Res 13(2): 153-66. (1996).
[http://dx.doi.org/10.3109/08990229609051403] [PMID: 8844964]
[16]
Suvà D, Favre I, Kraftsik R, Esteban M, Lobrinus A, Miklossy J. Primary motor cortex involvement in Alzheimer disease. J Neuropathol Exp Neurol 58(11): 1125-34. (1999).
[http://dx.doi.org/10.1097/00005072-199911000-00002] [PMID: 10560655]
[17]
Baddeley A, Logie R, Bressi S, Della Sala S, Spinnler H. Dementia and working memory. Q J Exp Psychol A 38(4): 603-18. (1986).
[http://dx.doi.org/10.1080/14640748608401616] [PMID: 3809575]
[18]
Abdulkadir A, Ronneberger O, Wolf RC, Pfleiderer B, Saft C, Klöppel S. Functional and structural MRI biomarkers to detect pre-clinical neurodegeneration. Curr Alzheimer Res 10(2): 125-34. (2013).
[http://dx.doi.org/10.2174/1567205011310020002] [PMID: 22742852]
[19]
Baddeley AD, Bressi S, Della Sala S, Logie R, Spinnler H. The decline of working memory in Alzheimer’s disease. A longitudinal study. Brain 114(Pt 6): 2521-42. (1991).
[http://dx.doi.org/10.1093/brain/114.6.2521] [PMID: 1782529]
[20]
Kessels RP, Molleman PW, Oosterman JM. Assessment of working-memory deficits in patients with mild cognitive impairment and Alzheimer’s dementia using Wechsler’s Working Memory Index. Aging Clin Exp Res 23(5-6): 487-90. (2011).
[http://dx.doi.org/10.1007/BF03325245] [PMID: 22526081]
[21]
Belleville S, Rouleau N, Van der Linden M, Collette F. Effect of manipulation and irrelevant noise on working memory capacity of patients with Alzheimer’s dementia. Neuropsychology 17(1): 69-81. (2003).
[http://dx.doi.org/10.1037/0894-4105.17.1.69] [PMID: 12597075]
[22]
Burgess PW, Shallice T. The Hayling and Brixton tests Bury St Edmunds, England: Thames Valley Test Company 1997.
[23]
Peters ME, Schwartz S, Han D, et al. Neuropsychiatric symptoms as predictors of progression to severe Alzheimer’s dementia and death: the Cache County Dementia Progression Study. Am J Psychiatry 172(5): 460-5. (2015).
[http://dx.doi.org/10.1176/appi.ajp.2014.14040480] [PMID: 25585033]
[24]
Castel AD, Balota DA, McCabe DP. Memory efficiency and the strategic control of attention at encoding: impairments of value-directed remembering in Alzheimer’s disease. Neuropsychology 23(3): 297-306. (2009).
[http://dx.doi.org/10.1037/a0014888] [PMID: 19413444]
[25]
Yang J, Ogasa T, Ohta Y, Abe K, Wu J. Decline of human tactile angle discrimination in patients with mild cognitive impairment and Alzheimer’s disease. J Alzheimers Dis 22(1): 225-34. (2010).
[http://dx.doi.org/10.3233/JAD-2010-100723] [PMID: 20847416]
[26]
Oldfield RC. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9(1): 97-113. (1971).
[http://dx.doi.org/10.1016/0028-3932(71)90067-4] [PMID: 5146491]
[27]
Guo QH, Sun YM, Pei-Min YU, Hong Z. Norm of auditory verbal learning test in the normal aged in china community. Chin J Clin Psychol 15: 132-4. (2007).
[28]
Lu J, Li D, Li F, et al. Montreal cognitive assessment in detecting cognitive impairment in Chinese elderly individuals: a population-based study. J Geriatr Psychiatry Neurol 24(4): 184-90. (2011).
[http://dx.doi.org/10.1177/0891988711422528] [PMID: 22228824]
[29]
Morris JC. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 43(11): 2412-4. (1993).
[http://dx.doi.org/10.1212/WNL.43.11.2412-a] [PMID: 8232972]
[30]
Dozeman E, van Schaik DJ, van Marwijk HW, Stek ML, van der Horst HE, Beekman AT. The center for epidemiological studies depression scale (CES-D) is an adequate screening instrument for depressive and anxiety disorders in a very old population living in residential homes. Int J Geriatr Psychiatry 26(3): 239-46. (2011).
[http://dx.doi.org/10.1002/gps.2519] [PMID: 20623777]
[31]
Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 23: 56-62. (1960).
[http://dx.doi.org/10.1136/jnnp.23.1.56] [PMID: 14399272]
[32]
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 34(7): 939-44. (1984).
[http://dx.doi.org/10.1212/WNL.34.7.939] [PMID: 6610841]
[33]
McKhann GM, Knopman DS, Chertkow H, et al. The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7(3): 263-9. (2011).
[http://dx.doi.org/10.1016/j.jalz.2011.03.005] [PMID: 21514250]
[34]
De Weerd P, Vandenbussche E, Orban GA. Staircase procedure and constant stimuli method in cat psychophysics. Behav Brain Res 40(3): 201-14. (1990).
[http://dx.doi.org/10.1016/0166-4328(90)90077-R] [PMID: 2285478]
[35]
Molinuevo JL, Rabin LA, Amariglio R, et al. Implementation of subjective cognitive decline criteria in research studies. Alzheimers Dement 13(3): 296-311. (2017).
[http://dx.doi.org/10.1016/j.jalz.2016.09.012] [PMID: 27825022]
[36]
Ester EF, Sprague TC, Serences JT. parietal and frontal cortex encode stimulus-specific mnemonic representations during visual working memory. Neuron 87(4): 893-905. (2015).
[http://dx.doi.org/10.1016/j.neuron.2015.07.013] [PMID: 26257053]
[37]
Brodt S, Pöhlchen D, Flanagin VL, Glasauer S, Gais S, Schönauer M. Rapid and independent memory formation in the parietal cortex. Proc Natl Acad Sci USA 113(46): 13251-6. (2016).
[http://dx.doi.org/10.1073/pnas.1605719113] [PMID: 27803331]
[38]
Viviano RP, Hayes JM, Pruitt PJ, et al. Aberrant memory system connectivity and working memory performance in subjective cognitive decline. Neuroimage 185: 556-64. (2019).
[http://dx.doi.org/10.1016/j.neuroimage.2018.10.015] [PMID: 30308246]
[39]
Yang J, Yu Y, Kunita A, et al. Tactile priming modulates the activation of the fronto-parietal circuit during tactile angle match and non-match processing: an fMRI study. Front Hum Neurosci 8: 926. (2014).
[http://dx.doi.org/10.3389/fnhum.2014.00926] [PMID: 25566010]
[40]
Franzmeier N, Düzel E, Jessen F, et al. Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer’s disease. Brain 141(4): 1186-200. (2018).
[http://dx.doi.org/10.1093/brain/awy008] [PMID: 29462334]
[41]
Wang Z, Qiao K, Chen G, et al. Functional connectivity changes across the spectrum of subjective cognitive decline, amnestic mild cognitive impairment and Alzheimer’s disease. Front Neuroinform 13: 26. (2019).
[http://dx.doi.org/10.3389/fninf.2019.00026] [PMID: 31105548]
[42]
López-Sanz D, Bruña R, Garcés P, et al. Functional connectivity disruption in subjective cognitive decline and mild cognitive impairment: a common pattern of alterations. Front Aging Neurosci 9: 109. (2017).
[http://dx.doi.org/10.3389/fnagi.2017.00109] [PMID: 28484387]
[43]
Clark CM, Sheppard L, Fillenbaum GG, et al. Variability in annual mini-mental state examination score in patients with probable Alzheimer disease: a clinical perspective of data from the consortium to establish a registry for Alzheimer’s Disease. Arch Neurol 56(7): 857-62. (1999).
[http://dx.doi.org/10.1001/archneur.56.7.857] [PMID: 10404988]
[44]
O’Bryant SE, Humphreys JD, Smith GE, et al. Detecting dementia with the mini-mental state examination in highly educated individuals. Arch Neurol 65(7): 963-7. (2008).
[http://dx.doi.org/10.1001/archneur.65.7.963] [PMID: 18625866]
[45]
Black SA, Espino DV, Mahurin R, et al. The influence of noncognitive factors on the Mini-Mental State Examination in older Mexican-Americans: findings from the Hispanic EPESE. J Clin Epidemiol 52(11): 1095-102. (1999).
[http://dx.doi.org/10.1016/S0895-4356(99)00100-6] [PMID: 10527004]

Rights & Permissions Print Cite
Article Metrics
24
© 2024 Bentham Science Publishers | Privacy Policy