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Review Article

阿片类生长因子及其衍生物作为潜在的无毒多功能抗癌和镇痛化合物

卷 28, 期 4, 2021

发表于: 04 March, 2020

页: [673 - 686] 页: 14

弟呕挨: 10.2174/0929867327666200304122406

价格: $65

摘要

尽管在癌症发病机制、分子生物学、诊断、治疗和预防等方面的研究取得了重大进展，但在世界范围内，其发病率和死亡率仍居高不下。癌细胞对抗癌药物的耐药性仍然是当今肿瘤学的一个重大问题。此外，一个重要的挑战是抗癌药物不能选择性靶向肿瘤细胞，从而保留健康细胞。阿片类生长因子(OGF)，化学名称为MET -脑啡肽，是一种新的潜在的有效和安全治疗选择。它是一种内源性五肽(Tyr- Gly - Gly - Phee - Met)，具有抗肿瘤、镇痛和增强免疫功能。临床试验表明，单独使用OGF治疗，以及与标准化疗相结合，是一种安全、无毒的抗癌药物，可以缩小肿瘤大小。本文就OGF及其类似物的构效关系作一综述。我们还强调了具有镇痛、免疫调节活性和穿透血脑屏障能力的OGF衍生物，并可能作为安全药物用于提高癌症患者的化疗疗效和改善生活质量。这些综述表明，蛋氨酸脑啡肽及其类似物是开发新型、无毒、具有镇痛活性的抗癌药物的重要候选药物。我们需要更多的临床前和临床研究来探索这些机会。

关键词: 阿片类生长因子，脑啡肽，类似物，抗癌治疗，多功能化合物，靶向治疗

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