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Review Article

姜黄素通过外在和内在的凋亡途径使癌症对TRAIL诱导的凋亡产生敏感性。

卷 21, 期 9, 2020

页: [849 - 854] 页: 6

弟呕挨: 10.2174/1389450121666200302124426

价格: $65

摘要

肿瘤坏死因子（TNF）相关的凋亡诱导配体（TRAIL）是一种天然蛋白质，在我们人体的各种组织中表达。由于它可以选择性杀死癌细胞，使正常细胞不受伤害，因此它是一种很有前途的抗癌药。但是，耐药性可能是固有发生的，也可能是在TRAIL治疗过程中产生的。考虑到其对癌细胞的特异性，迫切需要克服TRAIL抗性。姜黄素（姜黄素）是姜黄的天然活性成分，已被证明具有抗癌特性。但是，它受难溶性和低生物利用度的限制。联合疗法是克服这些局限性的最常用策略之一，事实证明，通过实现协同作用和降低毒性，联合疗法比单一疗法更有效。这篇综述旨在讨论TRAIL及其潜在的凋亡机制，鉴于它们各自的局限性，对Cur和TRAIL进行联合治疗，以及通过Cur对TRAIL诱导的细胞凋亡敏化癌症激活的潜在凋亡机制。最后，这篇评论讨论了研究差距以及作者对缩小研究范围从长凳到床头的研究范围的见解。

关键词: 姜黄素，TRAIL，致敏作用，癌症，外在凋亡途径，内在凋亡途径。

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图形摘要

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