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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

阿尔茨海默氏病小鼠模型中顺行性失忆与完整逆行记忆的突触相关性

卷 17, 期 3, 2020

页: [259 - 268] 页: 10

弟呕挨: 10.2174/1567205017666200224122113

价格: $65

摘要

背景：临床证据表明，受阿尔茨海默氏病（AD）影响的患者尽管对旧事件的记忆完好无损，却无法形成新的记忆。这种记忆删除模式取决于对海马区AD神经神经变性的选择性脆弱性，该区域维持新记忆的形成的大脑区域，而存储远程记忆的皮质区域则被保留。 目的：确定AD小鼠模型中受损的近期记忆和完整的远程记忆的潜在细胞机制。 方法：通过膜片钳记录AD样Tg2576小鼠的急性海马和前扣带回皮层（aCC）切片以及经受情境恐惧条件（CFC）任务或处于幼稚条件下的野生型（Wt）同窝仔的谷氨酸能产生突触电流。 结果：我们在Tg2576小鼠中发现了最近记忆形成的缺陷，但没有发现远处记忆的缺陷。通过电生理学记录，我们在训练后一天检测到了Wt的CA1锥体细胞中CFC诱导的AMPA / NMDA比值的修饰，而Tg2576的小鼠中没有。训练后8天，在Wt和Tg2576小鼠的aCC中也检测到了CFC诱导的AMPA / NMDA比值的变化。 结论：我们的数据表明，在AD早期，CA1突触对形成新记忆至关重要的突触可塑性丧失，而aCC突触的可塑性却完好无损，并有助于长期记忆的持久性。

关键词: 阿尔茨海默氏病，近期记忆，远程记忆，海马，前扣带回皮层，突触可塑性，AMPA，NMDA。

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