摘要
背景:生物传感器广泛应用于检测血糖、胆固醇和基因中的生物分子。纤维素作为最主要的天然高分子材料,在医学领域,特别是在高级医学诊断领域受到越来越多的关注。纤维素可以使生物传感器具有更好的生物相容性、生物降解性和无毒性,有助于医学诊断。本文综述了近年来基于纤维素的生物传感器的研究进展及其在医学诊断中的应用。 方法:回顾近年来的研究成果,可以发现用于生物传感器的纤维素种类有不同的纤维素衍生物、细菌纤维素和纳米纤维素。摘要简要介绍了膜、纳米纤维素等不同类型的纤维素生物传感器的检测原理。对基于纤维素的生物传感器进行了综述。还介绍了用于制备纤维素基生物传感器的各种方法。 结果:纤维素及其衍生物以其独特的化学结构为生物传感器的生物活性分子固定化提供了良好的平台。这些以纤维素为基础的生物传感器具有各种令人满意的特性,如准确性、灵敏度、方便性、低成本和快速响应。其中,纤维素纸基生物传感器具有成本低、操作方便等优点。纳米纤维素具有纵横比大、分散性好、吸收能力强等独特性能。 结论:纤维素可用于检测葡萄糖、乳酸、尿素、基因、细胞、氨基酸、胆固醇、蛋白质和对苯二酚等不同生物分子,具有广阔的应用前景。未来的重点将放在设计小型化、多功能、智能化和集成化的生物传感器上。创造低成本和环境友好的生物传感器也非常重要。
关键词: 纤维素,生物传感器,制备,生物分子,医学诊断,纤维素衍生物,细菌纤维素。
[http://dx.doi.org/10.1016/j.pbi.2008.03.007] [PMID: 18485800]
[http://dx.doi.org/10.1007/s10570-018-1755-x]
[http://dx.doi.org/10.1016/j.carbpol.2014.10.049] [PMID: 25817683]
[http://dx.doi.org/10.1016/j.carbpol.2018.04.105] [PMID: 29804993]
[http://dx.doi.org/10.1002/jbm.a.36330] [PMID: 29316233]
[http://dx.doi.org/10.1007/s10570-010-9464-0]
[http://dx.doi.org/10.1038/nature06261] [PMID: 18046409]
[http://dx.doi.org/10.1002/adma.201104696] [PMID: 22454295]
[http://dx.doi.org/10.1126/science.1121357] [PMID: 16497924]
[http://dx.doi.org/10.1021/am4000485] [PMID: 23629451]
[http://dx.doi.org/10.1038/4551054a ] [PMID: 18948945 ]
[http://dx.doi.org/10.1016/j.cytogfr.2009.10.021] [PMID: 19914855]
[http://dx.doi.org/10.1016/S0140-6736(98)07037-8] [PMID: 9742977]
[http://dx.doi.org/10.1016/S0140-6736(98)07019-6] [PMID: 9742976]
[http://dx.doi.org/10.1111/j.1468-1331.2011.03570.x] [PMID: 22050286]
[http://dx.doi.org/10.1021/acsnano.6b06196] [PMID: 27973769]
[http://dx.doi.org/10.1016/S0956-5663(01)00313-X] [PMID: 11959464]
[http://dx.doi.org/10.3390/s131013928] [PMID: 24132229]
[http://dx.doi.org/10.1016/j.snb.2018.03.004]
[http://dx.doi.org/10.1007/s00216-015-9212-2] [PMID: 26781106]
[http://dx.doi.org/10.1016/j.carbpol.2017.01.056] [PMID: 28267519]
[http://dx.doi.org/10.1039/c0cs00108b] [PMID: 21566801]
[http://dx.doi.org/10.3390/ma10080977] [PMID: 28825682]
[http://dx.doi.org/10.1016/0032-3861(91)90435-L]
[http://dx.doi.org/10.1016/S0065-2318(10)64003-6] [PMID: 20837198]
[http://dx.doi.org/10.1007/s10570-011-9647-3]
[http://dx.doi.org/10.1021/am403622v] [PMID: 24070254]
[http://dx.doi.org/10.1021/bm201771m ] [PMID: 22360491]
[http://dx.doi.org/10.1016/j.bioelechem.2009.05.008] [PMID: 19535301]
[http://dx.doi.org/10.1088/1468-6996/11/1/014108] [PMID: 27877323]
[http://dx.doi.org/10.1002/jbm.b.32724] [PMID: 22692845]
[http://dx.doi.org/10.1016/j.bios.2011.01.043] [PMID: 21353521]
[http://dx.doi.org/10.1016/j.jelechem.2016.09.013]
[http://dx.doi.org/10.1007/s10570-013-0109-y]
[http://dx.doi.org/10.1016/j.carbpol.2015.10.010] [PMID: 26572428]
[http://dx.doi.org/10.1016/j.bej.2015.10.023]
[http://dx.doi.org/10.1007/s11814-014-0064-9]
[http://dx.doi.org/10.2217/nnm.12.211 PMID: 23394157]
[http://dx.doi.org/10.1002/biot.201500106] [PMID: 26395011]
[http://dx.doi.org/10.1016/j.biomaterials.2005.07.035] [PMID: 16099034]
[http://dx.doi.org/10.1016/j.cap.2008.12.038]
[http://dx.doi.org/10.1016/j.carbpol.2011.08.039] [PMID: 24751088]
[http://dx.doi.org/10.1016/j.polymer.2017.12.068]
[http://dx.doi.org/10.1021/cr900339w] [PMID: 20201500]
[http://dx.doi.org/10.1039/C4RA13057J]
[http://dx.doi.org/10.1021/acsami.6b11578] [PMID: 27933978]
[http://dx.doi.org/10.1021/bm049291k] [PMID: 15762678]
[http://dx.doi.org/10.1021/ma049300h]
[http://dx.doi.org/10.1002/elan.200804338]
[http://dx.doi.org/10.1016/j.talanta.2010.12.015] [PMID: 21315900]
[http://dx.doi.org/10.1002/elsc.201700033]
[http://dx.doi.org/10.1007/s10856-014-5182-8] [PMID: 24577945]
[http://dx.doi.org/10.1111/j.1749-6632.1962.tb13623.x] [PMID: 14021529]
[http://dx.doi.org/10.1038/214986a0] [PMID: 6055414]
[http://dx.doi.org/10.1021/ja01036a083] [PMID: 5784180]
[http://dx.doi.org/10.1016/j.trac.2013.12.014]
[http://dx.doi.org/10.1351/pac199163091247]
[http://dx.doi.org/10.1016/j.bios.2005.03.006] [PMID: 16257667]
[http://dx.doi.org/10.1021/cr068105t] [PMID: 18229952]
[http://dx.doi.org/10.1016/j.aca.2018.04.051] [PMID: 29801612]
[http://dx.doi.org/10.1007/4243_2008_022]
[PMID: 11261847]
[http://dx.doi.org/10.1038/s41598-017-18995-3] [PMID: 29330381]
[http://dx.doi.org/10.1016/j.aca.2018.04.015] [PMID: 29852990]
[http://dx.doi.org/10.1016/j.bios.2018.04.046] [PMID: 29709776]
[http://dx.doi.org/10.1016/j.bios.2018.03.058] [PMID: 29625331]
[http://dx.doi.org/10.1016/j.snb.2018.01.234]
[http://dx.doi.org/10.1016/j.bios.2018.02.053] [PMID: 29524914]
[http://dx.doi.org/10.3390/ma11030448] [PMID: 29562700]
[http://dx.doi.org/10.1016/j.aca.2018.02.010]
[http://dx.doi.org/10.1016/j.aca.2018.02.020] [PMID: 29501089]
[http://dx.doi.org/10.1016/j.aca.2018.02.076] [PMID: 29681278]
[http://dx.doi.org/10.1016/j.aca.2018.01.027] [PMID: 29475474]
[http://dx.doi.org/10.1016/j.snb.2007.12.021]
[http://dx.doi.org/10.1021/ac9021117] [PMID: 20000697]
[http://dx.doi.org/10.1016/j.bios.2007.07.001] [PMID: 17716889]
[http://dx.doi.org/10.1016/j.snb.2016.07.008]
[http://dx.doi.org/10.1007/s10570-016-1046-3]
[http://dx.doi.org/10.1016/j.talanta.2011.07.012] [PMID: 21872047]
[http://dx.doi.org/10.1007/s00604-006-0631-9]
[http://dx.doi.org/10.1039/an9881301519] [PMID: 3239814]
[http://dx.doi.org/10.1016/0265-928X(89)80031-8]
[http://dx.doi.org/10.1016/0003-2670(93)80206-Z]
[http://dx.doi.org/10.1016/S0003-2670(01)00853-4]
[http://dx.doi.org/10.1016/S0003-2670(00)82081-4]
[http://dx.doi.org/10.1016/S0956-5663(03)00218-5] [PMID: 14611754]
[http://dx.doi.org/10.1016/0003-2670(92)85059-F]
[http://dx.doi.org/10.1016/0003-2697(90)90023-3] [PMID: 2321749]
[http://dx.doi.org/10.1006/abio.1996.9950] [PMID: 9056196]
[http://dx.doi.org/10.1002/bio.617] [PMID: 11312542]
[http://dx.doi.org/10.1016/0003-2670(93)85120-9]
[http://dx.doi.org/10.1021/ac00120a007] [PMID: 8633784]
[http://dx.doi.org/10.1016/S0956-5663(98)00095-5] [PMID: 10028653]
[http://dx.doi.org/10.20964/2017.01.44]
[http://dx.doi.org/10.1016/j.biotechadv.2016.01.006] [PMID: 26845060]
[http://dx.doi.org/10.1021/acs.biomac.5b01100] [PMID: 26413931]
[http://dx.doi.org/10.3144/expresspolymlett.2008.90]
[http://dx.doi.org/10.1016/j.colsurfb.2009.12.023] [PMID: 20097546]
[http://dx.doi.org/10.1016/j.snb.2014.06.077]
[http://dx.doi.org/10.3390/s91007694] [PMID: 22408475]
[http://dx.doi.org/10.1016/j.bios.2017.06.061] [PMID: 28728008]
[http://dx.doi.org/10.1063/1.3687398] [PMID: 22662067]
[http://dx.doi.org/10.1021/ac9013989] [PMID: 20000334]
[http://dx.doi.org/10.3390/mi8040104]
[http://dx.doi.org/10.1039/C7NR00958E] [PMID: 28422254]
[http://dx.doi.org/10.1007/s00216-013-7013-z] [PMID: 23677254]
[http://dx.doi.org/10.1039/C5AN00054H] [PMID: 25893863]
[http://dx.doi.org/10.1021/am505689g] [PMID: 25318086]
[http://dx.doi.org/10.1021/ac900660p] [PMID: 19492815]
[http://dx.doi.org/10.1016/j.aca.2012.08.043] [PMID: 23084049]
[http://dx.doi.org/10.1039/C5AN02651B] [PMID: 26853370]
[http://dx.doi.org/10.1021/acssensors.7b00450] [PMID: 28901134]
[http://dx.doi.org/10.1016/j.talanta.2018.02.070] [PMID: 29567164]
[http://dx.doi.org/10.1073/pnas.0810903105] [PMID: 19064929]
[http://dx.doi.org/10.1039/c3lc50169h] [PMID: 23652632]
[http://dx.doi.org/10.1039/C4RA07112C]
[http://dx.doi.org/10.1039/C4AN01147C] [PMID: 25204446]
[http://dx.doi.org/10.1021/ac5008688] [PMID: 24932699]
[http://dx.doi.org/10.1021/acsami.5b10027] [PMID: 26693736]
[http://dx.doi.org/10.1007/s00216-018-0939-4] [PMID: 29455281]
[http://dx.doi.org/10.1007/s12257-018-0430-2]
[http://dx.doi.org/10.1016/j.bios.2013.11.065] [PMID: 24361420]
[http://dx.doi.org/10.2217/17435889.1.1.51] [PMID: 17716209]
[http://dx.doi.org/10.1038/micronano.2015.14]
[http://dx.doi.org/10.1039/C4TA02159B]
[http://dx.doi.org/10.1038/s41598-017-14878-9] [PMID: 29109407]
[http://dx.doi.org/10.1007/s00216-013-6911-4] [PMID: 23604524]
[http://dx.doi.org/10.1177/000456328101800501] [PMID: 7030187]
[http://dx.doi.org/10.1039/c2ra20156a]
[http://dx.doi.org/10.1016/j.snb.2018.01.129]
[http://dx.doi.org/10.2198/sbk.32.49]
[http://dx.doi.org/10.1002/jnr.24193] [PMID: 29090830]
[http://dx.doi.org/10.1016/j.talanta.2014.10.064] [PMID: 25618676]
[http://dx.doi.org/10.1016/j.snb.2017.08.071]
[http://dx.doi.org/10.1039/C3TB21378A] [PMID: 32261311]
[http://dx.doi.org/10.1016/j.memsci.2005.04.044 ]
[http://dx.doi.org/10.1016/j.matlet.2010.08.018]
[http://dx.doi.org/10.1016/j.ab.2009.06.038] [PMID: 19576165]
[http://dx.doi.org/10.1002/polb.10261]
[http://dx.doi.org/10.1016/j.carbpol.2011.10.046]
[http://dx.doi.org/10.1002/elan.200704165]
[http://dx.doi.org/10.1021/la020475z]
[http://dx.doi.org/10.1021/jp710767w]
[http://dx.doi.org/10.1021/cm034720r]
[http://dx.doi.org/10.1007/s10570-014-0515-9]
[http://dx.doi.org/10.1089/wound.2013.0463] [PMID: 25493206]
[http://dx.doi.org/10.1007/s10570-016-0873-6]
[http://dx.doi.org/10.3390/s151024681] [PMID: 26404269]
[http://dx.doi.org/10.1021/bm201676q] [PMID: 22248303]
[http://dx.doi.org/10.1021/cr300242j] [PMID: 23540980]
[http://dx.doi.org/10.1016/j.compscitech.2011.07.003]
[http://dx.doi.org/10.1039/C2EE23635D]
[http://dx.doi.org/10.1002/adma.201190123] [PMID: 21739489]
[http://dx.doi.org/10.1177/000456329303000603] [PMID: 8304722]
[http://dx.doi.org/10.1007/s00702-007-0777-6] [PMID: 17641816]
[http://dx.doi.org/10.17706/ijbbb.2015.5.4.241-248]
[http://dx.doi.org/10.1002/adfm.201604291]
[http://dx.doi.org/10.1021/acs.biomac.6b01681] [PMID: 28036163]
[http://dx.doi.org/10.1021/am200475b] [PMID: 21627309]
[http://dx.doi.org/10.1021/sc500738k]
[http://dx.doi.org/10.1007/s10570-018-1719-1]
[http://dx.doi.org/10.1039/C6RA12365A]
[http://dx.doi.org/10.1016/j.bios.2011.05.039] [PMID: 21683572]
[http://dx.doi.org/10.1016/j.talanta.2009.12.006] [PMID: 20188928]
[http://dx.doi.org/10.1016/j.snb.2014.02.077]
[http://dx.doi.org/10.1016/j.bios.2010.08.027] [PMID: 20833016]
[http://dx.doi.org/10.1007/s00604-016-1811-x]
[http://dx.doi.org/10.1016/j.snb.2017.05.041]
[http://dx.doi.org/10.1038/srep41214] [PMID: 28117357]
[http://dx.doi.org/10.1007/s00216-008-2572-0] [PMID: 19130044]
[http://dx.doi.org/10.1056/NEJM199312163292508] [PMID: 8305063]
[http://dx.doi.org/10.1016/j.talanta.2010.11.010] [PMID: 21238722]
[http://dx.doi.org/10.1016/j.colsurfa.2016.09.028]
[http://dx.doi.org/10.3390/molecules21050618]
[http://dx.doi.org/10.1039/C5AY01599E]
[http://dx.doi.org/10.1016/j.talanta.2014.07.027] [PMID: 25281099]
[http://dx.doi.org/10.1002/elan.201000235]