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Mini-Reviews in Organic Chemistry

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ISSN (Online): 1875-6298

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Mini-Review Article

Δα,β-Butenolides [Furan-2(5H)-ones]: Ring Construction Approaches and Biological Aspects - A Mini-Review

Author(s): Andrés-Felipe Villamizar-Mogotocoro, Andrés-Felipe León-Rojas and Juan-Manuel Urbina-González*

Volume 17, Issue 8, 2020

Page: [922 - 945] Pages: 24

DOI: 10.2174/1570193X17666200220130735

Price: $65

Abstract

The five-membered oxacyclic system of furan-2(5H)-ones, commonly named as γ- butenolides or appropriately as Δα,β-butenolides, is of high interest since many studies have proven its bioactivity. During the past few years, Δα,β-butenolides have been important synthetic targets, with several reports of new procedures for their construction. A short compendium of the main different synthetic methodologies focused on the Δα,β-butenolide ring formation, along with selected examples of compounds with relevant biological activities of these promising pharmaceutical entities is presented.

Keywords: Δα, β-butenolide, butenolactone, furan-2(5H)-one, isocrotonolactone, unsaturated γ lactone, γ-butenolide.

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