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Review Article

蛋白质相互作用域:结构特征和药物发现应用(第二部分)

卷 28, 期 5, 2021

发表于: 14 January, 2020

页: [854 - 892] 页: 39

弟呕挨: 10.2174/0929867327666200114114142

价格: $65

摘要

背景：蛋白质呈现一个由几个域组成的模块化组织。除了发挥催化作用的域外，还有许多其他的域对于招募相互作用者至关重要。后一种结构域被定义为“PID”(蛋白相互作用结构域)，负责信号转导和一系列正常生理和疾病相关通路的关键结果。用小分子和多肽靶向这些PID能够调节它们的相互作用网络，可能是发现新疗法的有价值的途径。 目的：这项工作是最近一篇描述PID能够识别翻译后修饰肽段的综述的延续。相反，第二部分涉及的是与含有标准氨基酸的简单肽序列相互作用的PID。 方法：通过广泛搜索不同的在线数据库(包括PDB(蛋白质数据库)、Pfam(蛋白质家族)和SMART(简单模块化结构研究工具)，我们获得了不同领域亚家族及其相互作用组的关键结构信息。Pubmed也被搜索以探索与该主题相关的最新文献。 结果和结论：PID是多方面的:它们有各种不同的结构特征，可以识别几个共识序列。pid可能与不同疾病的发病和进展有关，如癌症或病毒感染，并在个性化医疗领域得到应用。目前，许多研究工作都集中在肽类/拟肽类抑制剂上，但在提高已鉴定化合物的药物相似性和相互作用亲和力方面，还需要做更多的工作。

关键词: 蛋白质相互作用域，蛋白质-蛋白质相互作用，结构，药物发现，配体，抑制剂，肽，小分子

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