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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

中性粒细胞-淋巴细胞比率与中国老年人轻度认知障碍的关系：病例对照研究

卷 16, 期 14, 2019

页: [1309 - 1315] 页: 7

弟呕挨: 10.2174/1567205017666200103110521

价格: $65

摘要

背景：在先前的研究中，炎症在认知障碍的病理生理中起着重要作用。中性粒细胞-淋巴细胞比率（NLR）是系统性炎症的可靠指标。 目的：本研究旨在探讨NLR与轻度认知障碍（MCI）之间的关联，并进一步探索NLR炎症标志物对中国老年人MCI的诊断潜力。 方法：本研究连续评估了186名MCI受试者和153名认知功能正常的受试者。在空腹血样中测量中性粒细胞（NEUT）计数和淋巴细胞（LYM）计数。通过将绝对NEUT计数除以绝对LYM计数来计算NLR。多变量logistic回归用于评估NLR和MCI之间的潜在关联。使用接收器工作特性（ROC）曲线分析对用于预测MCI的NLR进行了分析。 结果：MCI组的NLR明显高于具有正常认知功能的受试者的NLR（2.39×0.55对1.94×0.51，P <0.001）。 Logistic回归分析显示，较高的NLR是MCI的独立危险因素（OR：4.549，95％CI：2.623-7.889，P <0.001）。 ROC分析表明，MCI的最佳NLR截止点为2.07，敏感性为73.66％，特异性为69.28％，阳性预测值（PPV）为74.48％，阴性预测值（NPV）为68.36％。相对于NLR <2.07，NLR≥2.07的受试者表现出更高的风险（或：5.933，95％CI：3.467-10.155，P <0.001）。 结论：NLR升高与MCI风险增加显着相关。特别是，高于2.07阈值的NLR水平与MCI的可能性显着相关。

关键词: 中性粒细胞-淋巴细胞比率，轻度认知障碍，全身性炎症，临界值，老年人，病例对照研究。

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