Abstract
The resistance among various microbial species (infectious agents) to different antimicrobial drugs has emerged as a cause of serious public health problem all over the world. In this sense, natural products have been a rich source of compounds for drug discovery with antibiotic activity. Macrolactins are amazing structures which have antibiotic activity against some clinically relevant pathogens. In addition, they have anti-inflammatory, antifungal, antimicrobial, and antitumor activities. They are macrolides containing 24-membered lactone ring with some differences in their chemical structures. The synthesis of these compounds is a difficult task which has attracted attention of researchers; however few syntheses have been reported. In this review, the isolation of all reported macrolactins, their syntheses and biological activities are revisited.
Keywords: Macrolactins, antibiotics, natural products, microorganisms, isolation, biological activities.
Graphical Abstract
[http://dx.doi.org/10.1021/ja00201a036]
[http://dx.doi.org/10.1021/np070070k] [PMID: 17844999]
[http://dx.doi.org/10.1021/np990605c] [PMID: 10924180]
[http://dx.doi.org/10.7164/antibiotics.54.333] [PMID: 11426657]
[http://dx.doi.org/10.1016/j.bmcl.2006.06.058] [PMID: 16809037]
[http://dx.doi.org/10.1128/AAC.50.5.1701-1709.2006] [PMID: 16641438]
[http://dx.doi.org/10.1080/14786410701768162] [PMID: 18322849]
[http://dx.doi.org/10.1038/ja.2008.98] [PMID: 19168985]
[http://dx.doi.org/10.1021/np0701327] [PMID: 17887720]
[http://dx.doi.org/10.1016/j.bmcl.2010.12.050] [PMID: 21570834]
[http://dx.doi.org/10.1021/jf504845m] [PMID: 25420039]
[http://dx.doi.org/10.1080/14786419.2016.1155576] [PMID: 27071303]
[http://dx.doi.org/10.3390/md14110195] [PMID: 27792158]
[http://dx.doi.org/10.1021/ja963543a]
[http://dx.doi.org/10.1002/(SICI)1521-3773(19980518)37:9<1261:: AID-ANIE1261>3.0.CO;2-2] [PMID: 29711229]
[http://dx.doi.org/10.1021/ja017177t] [PMID: 11853441]
[http://dx.doi.org/10.1016/j.tetlet.2003.11.055]
[http://dx.doi.org/10.1246/cl.2005.906]
[http://dx.doi.org/10.1016/j.tetlet.2007.11.107]
[http://dx.doi.org/10.1021/acs.orglett.5b02149] [PMID: 26349917]
[http://dx.doi.org/10.1055/s-0036-1589132]