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Current Medical Imaging

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ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

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Research Article

Multi-level 3D Densenets for False-positive Reduction in Lung Nodule Detection Based on Chest Computed Tomography

Author(s): Xiaoqi Lu, Yu Gu*, Lidong Yang, Baohua Zhang, Ying Zhao, Dahua Yu, Jianfeng Zhao, Lixin Gao, Tao Zhou, Yang Liu and Wei Zhang

Volume 16, Issue 8, 2020

Page: [1004 - 1021] Pages: 18

DOI: 10.2174/1573405615666191113122840

Abstract

Objective: False-positive nodule reduction is a crucial part of a computer-aided detection (CADe) system, which assists radiologists in accurate lung nodule detection. In this research, a novel scheme using multi-level 3D DenseNet framework is proposed to implement false-positive nodule reduction task.

Methods: Multi-level 3D DenseNet models were extended to differentiate lung nodules from falsepositive nodules. First, different models were fed with 3D cubes with different sizes for encoding multi-level contextual information to meet the challenges of the large variations of lung nodules. In addition, image rotation and flipping were utilized to upsample positive samples which consisted of a positive sample set. Furthermore, the 3D DenseNets were designed to keep low-level information of nodules, as densely connected structures in DenseNet can reuse features of lung nodules and then boost feature propagation. Finally, the optimal weighted linear combination of all model scores obtained the best classification result in this research.

Results: The proposed method was evaluated with LUNA16 dataset which contained 888 thin-slice CT scans. The performance was validated via 10-fold cross-validation. Both the Free-response Receiver Operating Characteristic (FROC) curve and the Competition Performance Metric (CPM) score show that the proposed scheme can achieve a satisfactory detection performance in the falsepositive reduction track of the LUNA16 challenge.

Conclusion: The result shows that the proposed scheme can be significant for false-positive nodule reduction task.

Keywords: Lung nodule detection, false-positive reduction, multi-level 3D DenseNets, computer-aided detection, convolutional neural networks.

Graphical Abstract

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