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Review Article

非编码RNA相关竞争性内源RNA监管网络：肝纤维化的新型治疗方法。

卷 19, 期 5, 2019

页: [305 - 317] 页: 13

弟呕挨: 10.2174/1566523219666191107113046

价格: $65

摘要

肝纤维化或瘢痕形成是由慢性肝损伤引起的最常见的病理特征，并且被广泛认为是发病率和死亡率的主要原因之一。它的主要特征是肝星状细胞（HSC）活化和细胞外基质（ECM）蛋白沉积过多。大量证据表明，几种非编码RNA（ncRNA）失调，主要是长的非编码RNA（lncRNA），microRNA（miRNA）和环状RNA（circRNA），这有助于HSC的活化和肝纤维化的发展。这些ncRNA不仅与它们的靶基因结合以促进肝纤维化的发展和消退，而且还通过与miRNA纺丝形成信号级联反应而充当竞争性内源RNA（ceRNA）。在这些信号级联反应中，lncRNA-miRNA-mRNA和circRNA-miRNA-mRNA是肝纤维化的起始，进展和消退的关键调节剂。因此，靶向这些相互作用的ncRNA级联可以作为抑制HSC活化以及预防和消退肝纤维化的新型且潜在的治疗靶标。

关键词: 肝纤维化，非编码RNA，竞争性内源RNA，NAFLD，环状RNA，microRNA。

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